Zinc-containing denture adhesive: a potential source of excess zinc resulting in copper deficiency myelopathy

Doherty, K.; Connor, Myles; Cruickshank, R.

doi:10.1038/sj.bdj.2011.428

Cited by 30 publications

(22 citation statements)

References 10 publications

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“…This effect has also been observed in clinical comparisons of denture adhesives 28) . Recent concerns have arisen about the adverse systemic effects of denture adhesives, due to reports that excessive zinc ingestion from denture adhesive overuse may cause depression of serum copper, resulting in bone marrow depression and widespread sensory and motor neuropathies 27,29) . Minimizing the use of denture adhesives while maximizing their effectiveness may be the best way to avoid adverse systemic effects.…”

Section: Discussionmentioning

confidence: 99%

Influence of composition on the adhesive strength and initial viscosity of denture adhesives

et al. 2014

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To investigate the effect of composition on the initial viscosity and adhesive strength between denture adhesives and the denture base. Two types of water-soluble polymers (methoxy ethylene maleic anhydride copolymer [PVM-MA] and sodium carboxymethyl cellulose [CMC]) were used. Samples were divided into three groups. Group 1 contained only PVM-MA; Group 2 contained only CMC; and Group 3 contained PVM-MA and CMC. The initial viscosity and adhesive strength were measured. For Group 1, the initial viscosity increased significantly as PVM-MA content increased. The adhesive strength of Group 1 lasted longer than Group 2. The adhesive strength of Group 3 varied greatly. The ratio of CMC and PVM-MA has a significant effect on the initial viscosity and adhesive strength of denture adhesives. Our results suggest that it is possible to improve the durability of a denture adhesive by combining different water-soluble polymers.

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Section: Discussionmentioning

confidence: 99%

Influence of composition on the adhesive strength and initial viscosity of denture adhesives

et al. 2014

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“…These effects reflect the remarkably diverse functions of the essential metal zinc which serves structural and/or catalytic roles in hundreds of peptides, including the zinc finger proteins [11]–[13]. However, zinc is also toxic when in excess and can attenuate copper and iron [14] uptake, even leading to mortality [15], [16] or memory impairment [17] or acute pancreatitis [18]–[20]. Therefore, the maintenance of zinc homeostasis is critical and approaches to facilitating the efficacy and reducing the toxicity of zinc supplementations are needed.…”

Section: Introductionmentioning

confidence: 99%

Clioquinol Synergistically Augments Rescue by Zinc Supplementation in a Mouse Model of Acrodermatitis Enteropathica

et al. 2013

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BackgroundZinc deficiency due to poor nutrition or genetic mutations in zinc transporters is a global health problem and approaches to providing effective dietary zinc supplementation while avoiding potential toxic side effects are needed.Methods/Principal FindingsConditional knockout of the intestinal zinc transporter Zip4 (Slc39a4) in mice creates a model of the lethal human genetic disease acrodermatitis enteropathica (AE). This knockout leads to acute zinc deficiency resulting in rapid weight loss, disrupted intestine integrity and eventually lethality, and therefore provides a model system in which to examine novel approaches to zinc supplementation. We examined the efficacy of dietary clioquinol (CQ), a well characterized zinc chelator/ionophore, in rescuing the Zip4 intest KO phenotype. By 8 days after initiation of the knockout neither dietary CQ nor zinc supplementation in the drinking water was found to be effective at improving this phenotype. In contrast, dietary CQ in conjunction with zinc supplementation was highly effective. Dietary CQ with zinc supplementation rapidly restored intestine stem cell division and differentiation of secretory and the absorptive cells. These changes were accompanied by rapid growth and dramatically increased longevity in the majority of mice, as well as the apparent restoration of the homeostasis of several essential metals in the liver.ConclusionsThese studies suggest that oral CQ (or other 8-hydroxyquinolines) coupled with zinc supplementation could provide a facile approach toward treating zinc deficiency in humans by stimulating stem cell proliferation and differentiation of intestinal epithelial cells.

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“…The sole source of the neurological disorders in using the excess Zn denture adhesive was identified by Nations et al and Hedera et al 18 . Recently a study found that excess Zn adhesive is also a potential cause for copper deficiency myelopathy 19 .…”

Section: Discussion:-mentioning

confidence: 99%

Knowledge, Attitude and Practice of Dental Adhesive Use Among Dental Practitioners of Chennai City- A Cross Sectional Study.

Subashri¹

2017

IJAR

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Zinc-containing denture adhesive: a potential source of excess zinc resulting in copper deficiency myelopathy

Cited by 30 publications

References 10 publications

Influence of composition on the adhesive strength and initial viscosity of denture adhesives

Influence of composition on the adhesive strength and initial viscosity of denture adhesives

Clioquinol Synergistically Augments Rescue by Zinc Supplementation in a Mouse Model of Acrodermatitis Enteropathica

Knowledge, Attitude and Practice of Dental Adhesive Use Among Dental Practitioners of Chennai City- A Cross Sectional Study.

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