Background: Since the 1970s, the World Health Organization has defined four-handed dentistry as a simplified method with defined tasks within the work team. It has been mainly implemented in clinics and universities in Brazil, the United States, Spain, and Chile. The comprehensive adult dental clinic (Sixth semester) and the pediatric dental clinic (Seventh and Eighth semesters) of the pre-doctoral dental program at El Bosque University’ Dental School (Bogotá, Colombia) use this method. However, theory on four-handed dentistry has not been included in the curriculum yet. Purpose: To explore and describe the influence of the four-handed method in the training of general dentists in order to justify its inclusion in the predoctoral curriculum. Methods: A search of articles was carried out until June 2020. Full-text selected articles were analyzed, and findings related to this study’s purpose were included in the review. Results: 13 articles were chosen. Findings are organized in three thematic axes: background and general aspects of the technique, benefits of the technique in the training of general dentists, and description of the four-handed care model as an exercise in the pediatric dental clinics, also called Growth and Development clinics, at El Bosque University. Conclusions: Patient care using a four-handed method can contribute to the development of soft skills, critical thinking, problem solving through collaborative work, and promoting meaningful learning in students.