Dentin regeneration based on tooth tissue engineering: A review

Abstract

Missing or damaged teeth due to caries, genetic disorders, oral cancer, or infection may contribute to physical and mental impairment that reduces the quality of life.Despite major progress in dental tissue repair and those replacing missing teeth with prostheses, clinical treatments are not yet entirely satisfactory, as they do not regenerate tissues with natural teeth features. Therefore, much of the focus has centered on tissue engineering (TE) based on dental stem/progenitor cells to create bioengineered dental tissues. Many in vitro and in vivo studies have shown the use of cells in regenerating sections of a tooth or a whole tooth. Tooth tissue engineering (TTE), as a promising method for dental tissue regeneration, can form durable biological substitutes for soft and mineralized dental tissues. The cell-based TE approach, which directly seeds cells and bioactive components onto the biodegradable scaffolds, is currently the most potential method. Three essential components of this strategy are cells, scaffolds, and growth factors (GFs). This study investigates dentin regeneration after an injury such as caries using TE and stem/progenitor cell-based strategies. We begin by discussing about the biological structure of a dentin and dentinogenesis.The engineering of teeth requires knowledge of the processes that underlie the growth of an organ or tissue. Then, the three fundamental requirements for dentin regeneration, namely cell sources, GFs, and scaffolds are covered in the current study, which may ultimately lead to new insights in this field.

Application of mesenchymal stem cells in regenerative medicine: A new approach in modern medical science

“…27 Additionally, dental MSCs exhibit immune-regulating properties by secreting cytokines. 27,28 Adult MSCs derived from dental tissues have attracted more attention in regenerative medicine in recent years than other MSCs due to their relatively faster proliferation rate, genomic stability, and unique evolutionary origin. 26…”

“…These cells are also easily accessible 27 and are considered an effective tool in stem cell‐based therapy due to their potential for multilinear differentiation, easy access, and immune system modulating effects 27 . Additionally, dental MSCs exhibit immune‐regulating properties by secreting cytokines 27,28 …”

A New Landscape of Human Dental Aging: Causes, Consequences, and Intervention Avenues

“…Despite advances in dental tissue repair and techniques replacing missing teeth with prostheses, clinical treatments cannot regenerate tissues with natural teeth properties. In contrast, tooth tissue engineering (TTE), a promising method for dental tissue regeneration, holds the potential to form durable biological substitutes for soft and mineralized dental tissues [93]. To date, however, partial or complete tooth reconstruction remains a major challenge for future studies of dentistry and oral medicine [17][18][19].…”

Effect of HM-Exos on the migration and inflammatory response of LPS-exposed dental pulp stem cells

“…The first stem cells derived from adult human dental pulp were dental pulp stem cells (DPSCs). These cells are separated from the third molar and have a high rate of proliferation and self-renewal [20]. Because of their tremendous potential in tissue repair/regeneration and immune response regulation, they have been indicated as a prospective choice for cell-based therapeutic applications.…”