Dental Tissue-Derived Stem Cells as a Candidate for Neural Regeneration

Malekzadeh, Samira; Edalatmanesh, Mohammad Amin; Mehrabani, Davood; Shariati, Mehrdad; Malekzadeh, Sima

doi:10.15562/gnc.60

Cited by 3 publications

(2 citation statements)

References 49 publications

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“…SCO is widely used as a model for studying therapeutic agents in AD therapy for induction of memory deficit in experimental animals. [ 30 ] In this study, we showed that SCO promoted memory impairment in the animals. The object recognition test results illustrated that SCO increases the latency to figure out a familiar object compared to a new object.…”

Section: Discussionmentioning

confidence: 73%

Inhibition of scopolamine‐induced memory and mitochondrial impairment by betanin

Salimi

Sabur

Dadkhah

et al. 2022

J Biochem & Molecular Tox

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Mitochondrial dysfunction and oxidative stress are identified to contribute to the mechanisms responsible for the pathogenesis of Alzheimer's disease (AD). Scopolamine (SCO) as a potent drug for inducing memory and learning impairment is associated with mitochondrial dysfunction and oxidative stress. In AD clinical trials molecules with antioxidant properties have shown modest benefit. Betanin as a multifunctional molecule with powerful antioxidative properties may be effective in the treatment of neurodegenerative. Hence, this study was designed to investigate the possible therapeutic effect of betanin against SCO-induced AD on Wistar rats. SCO (1 mg/kg) was administrated intraperitoneally to induce the AD in Wistar rats. The rats were treated with betanin doses (25 mg/kg and 50 mg/kg) intraperitoneally for 9 consecutive days. At the end of the 9th day, the animals were subjected to behavioral examination such as novel object recognition and passive avoidance tests and killed to study the mitochondrial and histological parameters. The results showed attenuation of SCO-induced memory and learning impairment by betanin at 50 mg/kg dose. Also, mitochondrial toxicity parameters such as mitochondrial membrane potential collapse, mitochondrial swelling, decreased activity of succinate dehydrogenase, and reactive oxygen species (ROS) production were reversed by betanin (50 mg/kg) compared to the SCO group. In addition, the ameliorative effect of betanin against SCO was demonstrated in histopathological results of hippocampus. The present investigation established that the betanin ameliorates the SCO-induced memory impairments, tissue injuries, and mitochondrial dysfunction by reducing mitochondrial ROS, which may be due to the potent antioxidant action of betanin.

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Section: Discussionmentioning

confidence: 73%

Inhibition of scopolamine‐induced memory and mitochondrial impairment by betanin

Salimi

Sabur

Dadkhah

et al. 2022

J Biochem & Molecular Tox

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“…Dental-tissue-derived stem cells (DTDSCs) consist of six types of stem cells which can be isolated from the different anatomical locations on the dental tissues. However, it was shown that most of these DTDSCs lack a key feature of the MSCs which is multi-potency ( 7 ). Human MSCs pose a unique molecular fingerprint by expressing CD105, CD44, CD90, and CD73 but not CD79a, CD45, CD34, CD19, CD14, CD11b, and HLA-DR.…”

Section: Introductionmentioning

confidence: 99%

Mesenchymal Stromal/Stem Cells: A New Era in the Cell-Based Targeted Gene Therapy of Cancer

et al. 2017

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In recent years, in light of the promising potentials of mesenchymal stromal/stem cells (MSCs) for carrying therapeutic anticancer genes, a complete revisitation on old chemotherapy-based paradigms has been established. This review attempted to bring forward and introduce the novel therapeutic opportunities of using genetically engineered MSCs. The simplicities and advantages of MSCs for medical applications make them a unique and promising option in the case of cancer therapy. Some of the superiorities of using MSCs as therapeutic gene micro-carriers are the easy cell-extraction procedures and their abundant proliferation capacity in vitro without losing their main biological properties. Targeted therapy by using MSCs as the delivery vehicles of therapeutic genes is a new approach in the treatment of various types of cancers. Some of the distinct properties of MSCs, such as tumor-tropism, non-immunogenicity, stimulatory effect on the anti-inflammatory molecules, inhibitory effect on inflammatory responses, non-toxicity against the normal tissues, and easy processes for the clinical use, have formed the basis of attention to MSCs. They can be easily used for the treatment of damaged or injured tissues, regenerative medicine, and immune disorders. This review focused on the drugability of MSCs and their potential for the delivery of candidate anticancer genes. It also briefly reviewed the vectors and methods used for MSC-mediated gene therapy of malignancies. Also, the challenges, limitations, and considerations in using MSCs for gene therapy of cancer and the new methods developed for resolution of these problems are reviewed.

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The Effect of Endurance Training and Crocin Consumption on Anxiety-like Behaviors and Aerobic Power in Rats with Alzheimer’s

Azarian

Farsi

Hosseini

et al. 2019

Iran J Psychiatry Behav Sci

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Background: Anxiety, depression, and physical problems are the problems of patients with Alzheimer's disease (AD). It has been reported that exercises and crocin consumption can improve the anxiety-like behaviors and aerobic power in patients with AD. Objectives: The present study aimed to investigate the interactive effect of endurance training and crocin on anxiety-like behaviors and aerobic power of rats with AD. Methods: In this experimental study, 40 male rats with AD (with mean age of eight weeks) were divided into five groups, including (1) control (C), (2) endurance training (ET), (3) endurance training and crocin (ETCR), (4) crocin (CR), and (5) sham (Sh). During eight weeks, the rats in groups 2 and 3 ran on treadmill for three sessions per week and groups 3 and 4 received 25 mg/kg of crocin peritoneally each day. Anxiety-like behaviors were assessed by elevated plus-maze and aerobic power test using rats' treadmill test. Results: Endurance training significantly decreased weight and anxiety-like behaviors as well as increased aerobic power (P ≤ 0.05); crocin significantly decreased anxiety-like behaviors and increased aerobic power (P ≤ 0.05); however, the interaction of endurance training and crocin consumption were not significant in the reduction of weight and anxiety-like behaviors and increase of aerobic power (P ≤ 0.05). Conclusions: It seems that endurance training and crocin consumption distinctly function and from different pathways effective in decreasing anxiety and increasing aerobic power in rats with AD.

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Dental Tissue-Derived Stem Cells as a Candidate for Neural Regeneration

Cited by 3 publications

References 49 publications

Inhibition of scopolamine‐induced memory and mitochondrial impairment by betanin

Inhibition of scopolamine‐induced memory and mitochondrial impairment by betanin

Mesenchymal Stromal/Stem Cells: A New Era in the Cell-Based Targeted Gene Therapy of Cancer

The Effect of Endurance Training and Crocin Consumption on Anxiety-like Behaviors and Aerobic Power in Rats with Alzheimer’s

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