Background: Anxiety, depression, and physical problems are the problems of patients with Alzheimer's disease (AD). It has been reported that exercises and crocin consumption can improve the anxiety-like behaviors and aerobic power in patients with AD. Objectives: The present study aimed to investigate the interactive effect of endurance training and crocin on anxiety-like behaviors and aerobic power of rats with AD. Methods: In this experimental study, 40 male rats with AD (with mean age of eight weeks) were divided into five groups, including (1) control (C), (2) endurance training (ET), (3) endurance training and crocin (ETCR), (4) crocin (CR), and (5) sham (Sh). During eight weeks, the rats in groups 2 and 3 ran on treadmill for three sessions per week and groups 3 and 4 received 25 mg/kg of crocin peritoneally each day. Anxiety-like behaviors were assessed by elevated plus-maze and aerobic power test using rats' treadmill test. Results: Endurance training significantly decreased weight and anxiety-like behaviors as well as increased aerobic power (P ≤ 0.05); crocin significantly decreased anxiety-like behaviors and increased aerobic power (P ≤ 0.05); however, the interaction of endurance training and crocin consumption were not significant in the reduction of weight and anxiety-like behaviors and increase of aerobic power (P ≤ 0.05). Conclusions: It seems that endurance training and crocin consumption distinctly function and from different pathways effective in decreasing anxiety and increasing aerobic power in rats with AD.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.