Dental pulp stem cells response on the nanotopography of scaffold to regenerate dentin-pulp complex tissue

Diana, Rasda; Ardhani, Retno; Kristanti, Yulita; Santosa, Pribadi

doi:10.1016/j.reth.2020.09.007

Cited by 16 publications

(11 citation statements)

References 54 publications

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“…Of note, the dental pulp contains the dental pulp stem cells (DPSCs), as well as the apical zone of the formed dental root contains the stem cells from apical papilla (SCAPs) (see [ 20 ] for review). Together, DPSCs and SCAPs constitute an important reservoir of stem cells in living teeth with promising properties in tissue repair and regeneration due to their ability to differentiate into epithelial and mesenchymal cells [ 21 , 22 , 23 , 24 ]).…”

Section: Expression and Action Of Gh/igf Axis In The Dento-alveolar Complexmentioning

confidence: 99%

“…In addition to this materials-based approach, some authors have also proposed the use of progenitor cells such as SCAPs, with or without scaffolds, whose properties may be also used in emerging regenerative endodontic procedures (REPs) as a treatment option for immature necrotic teeth to allow the reestablishment of a newly formed vital tissue and enable continued root development [ 21 , 23 , 97 ]. Indeed, as previously mentioned in Part 4, SCAP proliferation, migration, and formation of mineralized nodules is stimulated by IGF1 in a mixture of growth factors naturally present [ 65 ].…”

Section: Gh/igf and Oral Tissue Engineeringmentioning

confidence: 99%

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The Role of GH/IGF Axis in Dento-Alveolar Complex from Development to Aging and Therapeutics: A Narrative Review

Koffi

Doublier

Ricort

et al. 2021

Cells

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The GH/IGF axis is a major regulator of bone formation and resorption and is essential to the achievement of normal skeleton growth and homeostasis. Beyond its key role in bone physiology, the GH/IGF axis has also major pleiotropic endocrine and autocrine/paracrine effects on mineralized tissues throughout life. This article aims to review the literature on GH, IGFs, IGF binding proteins, and their respective receptors in dental tissues, both epithelium (enamel) and mesenchyme (dentin, pulp, and tooth-supporting periodontium). The present review re-examines and refines the expression of the elements of the GH/IGF axis in oral tissues and their in vivo and in vitro mechanisms of action in different mineralizing cell types of the dento-alveolar complex including ameloblasts, odontoblasts, pulp cells, cementoblasts, periodontal ligament cells, and jaw osteoblasts focusing on cell-specific activities. Together, these data emphasize the determinant role of the GH/IGF axis in physiological and pathological development, morphometry, and aging of the teeth, the periodontium, and oral bones in humans, rodents, and other vertebrates. These advancements in oral biology have elicited an enormous interest among investigators to translate the fundamental discoveries on the GH/IGF axis into innovative strategies for targeted oral tissue therapies with local treatments, associated or not with materials, for orthodontics and the repair and regeneration of the dento-alveolar complex and oral bones.

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Section: Expression and Action Of Gh/igf Axis In The Dento-alveolar Complexmentioning

confidence: 99%

Section: Gh/igf and Oral Tissue Engineeringmentioning

confidence: 99%

The Role of GH/IGF Axis in Dento-Alveolar Complex from Development to Aging and Therapeutics: A Narrative Review

Koffi

Doublier

Ricort

et al. 2021

Cells

View full text Add to dashboard Cite

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“…Interest in regenerative methods in dentistry is growing steadily. There are now a variety of approaches in tissue engineering for almost all anatomical areas of the tooth, in particular the enamel, dentin and pulp [ 375 ]. Anastasiou et al demonstrated the exogenous mineralization of hard tissues based on the use of femtosecond pulsed lasers and fluorapatite powder mixed with IONPs [ 376 ].…”

Section: Hard and Connective Tissue Regeneration And Engineeringmentioning

confidence: 99%

Iron Oxide Nanoparticles in Regenerative Medicine and Tissue Engineering

2021

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In recent years, many promising nanotechnological approaches to biomedical research have been developed in order to increase implementation of regenerative medicine and tissue engineering in clinical practice. In the meantime, the use of nanomaterials for the regeneration of diseased or injured tissues is considered advantageous in most areas of medicine. In particular, for the treatment of cardiovascular, osteochondral and neurological defects, but also for the recovery of functions of other organs such as kidney, liver, pancreas, bladder, urethra and for wound healing, nanomaterials are increasingly being developed that serve as scaffolds, mimic the extracellular matrix and promote adhesion or differentiation of cells. This review focuses on the latest developments in regenerative medicine, in which iron oxide nanoparticles (IONPs) play a crucial role for tissue engineering and cell therapy. IONPs are not only enabling the use of non-invasive observation methods to monitor the therapy, but can also accelerate and enhance regeneration, either thanks to their inherent magnetic properties or by functionalization with bioactive or therapeutic compounds, such as drugs, enzymes and growth factors. In addition, the presence of magnetic fields can direct IONP-labeled cells specifically to the site of action or induce cell differentiation into a specific cell type through mechanotransduction.

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“…In the research of Griffin [70], it was shown that nanotopography alone mapping the threedimensional features of the extracellular matrix (ECM) can induce stem cell stimulation. DPSCs respond to the alteration of nanotopography by altering gene expression, adhesion, migration, differentiation and proliferation [73].…”

Section: Characterisation Of Scaffolds and Growth Factorsmentioning

confidence: 99%

Therapeutic Potential of Dental Pulp Stem Cells According to Different Transplant Types

Staniowski

Zawadzka-Knefel

Skośkiewicz−Malinowska

2021

Molecules

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Stem cells are unspecialised cells capable of perpetual self-renewal, proliferation and differentiation into more specialised daughter cells. They are present in many tissues and organs, including the stomatognathic system. Recently, the great interest of scientists in obtaining stem cells from human teeth is due to their easy availability and a non-invasive procedure of collecting the material. Three key components are required for tissue regeneration: stem cells, appropriate scaffold material and growth factors. Depending on the source of the new tissue or organ, there are several types of transplants. In this review, the following division into four transplant types is applied due to genetic differences between the donor and the recipient: xenotransplantation, allotransplantation, autotransplantation and isotransplantation (however, due to the lack of research, type was not included). In vivo studies have shown that Dental Pulp Stem Cells (DPSCs)can form a dentin-pulp complex, nerves, adipose, bone, cartilage, skin, blood vessels and myocardium, which gives hope for their use in various biomedical areas, such as immunotherapy and regenerative therapy. This review presents the current in vivo research and advances to provide new biological insights and therapeutic possibilities of using DPSCs.

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Dental pulp stem cells response on the nanotopography of scaffold to regenerate dentin-pulp complex tissue

Cited by 16 publications

References 54 publications

The Role of GH/IGF Axis in Dento-Alveolar Complex from Development to Aging and Therapeutics: A Narrative Review

The Role of GH/IGF Axis in Dento-Alveolar Complex from Development to Aging and Therapeutics: A Narrative Review

Iron Oxide Nanoparticles in Regenerative Medicine and Tissue Engineering

Therapeutic Potential of Dental Pulp Stem Cells According to Different Transplant Types

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