Dental pulp stem cells for in vivo bone regeneration: A systematic review of literature

Purmorphamine increased adhesion, proliferation and expression of osteoblast phenotype markers of human dental pulp stem cells cultured on beta-tricalcium phosphate

“…Harvesting and isolating these progenitor population are relatively easy and a sufficient number of the cells can be provided in two weeks [22]. In addition, since dental pulp are derived from neural crest different origin from mesoderm-derived bone marrow stem cells, DPSCs may considered a better candidate for repair of damages in neural crest-derived tissues including oral and maxillofacial defects [30].…”

“…In particular, we have used human dental pulp stem cells (hDPSCs) for investigation of the Purmorphamine effects, since their clinical application seems feasible. Harvesting and isolating these progenitor population are relatively easy and their high osteogenic potential in treatment of skeletal defects has been shown before [22] 2. Material and methods…”

Effects of washed platelets vs platelet-rich plasma on the proliferation and mineralization of rat dental pulp cells

“…The calcium hydroxide method commonly used clinically in the past has a certain curative effect in retention treatment of dental pulp but it is not an ideal biological material from histological aspects, as the dental pulp tissue in direct contact with this material will be subjected to necrosis, potentially leading to outcomes such as calcification or degeneration of the residual dental pulp (Morad et al, 2013;Vishwanath et al, 2013). In addition, the heterogeneous or allogeneic biological materials currently being studied and used in retention treatment of vital dental pulp, such as sintered bovine-derived powder and dentin powder, impart a risk of infectious diseases such as HIV or variant Creutzfeldt-Jakob (mad cow) disease (Alkaisi et al, 2013;Saito et al, 2013).…”

Responses of human dental pulp cells after application of a low-concentration bleaching gel to enamel

“…Therefore, when they are lost, reparative dentinogenesis takes place, which involves mesenchymal stem cell (MSC) recruitment, proliferation, and differentiation into odontoblast-like cells, resulting in the deposition of mineralized matrix and restoration of the homeostasis of pulp tissue. [5][6][7] It was previously demonstrated that very low concentrations of H 2 O 2 induce odontoblastic differentiation and mineralized matrix deposition 8,9 ; conversely, toxic concentrations of H 2 O 2 enhance inflammatory mediator expression associated with the impairment of odontoblastic differentiation capability. [10][11][12][13][14] Recently, it was demonstrated that application of a lowconcentration H 2 O 2 gel (17.5%) from 5 to 45 min onto dental structure was able to reduce in about 11.3-4.5 times, respectively, the indirect toxicity of in-office tooth-bleaching to human dental pulp cells (HDPCs), when compared with traditional therapy (35% H 2 O 2 ; 3 Â 15 min).…”