Dental metal-induced innate reactivity in keratinocytes

Rachmawati, Dessy; Buskermolen, Jeroen Kees; Scheper, Rik J.; Gibbs, Susan; Blomberg, B. Mary E. von; Hoogstraten, Ingrid M.W. van

doi:10.1016/j.tiv.2015.10.003

Cited by 14 publications

(10 citation statements)

References 39 publications

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“…These current findings are in line with our previous findings and those of others who showed that CXCL8 was induced when DCs, macrophages, and keratinocytes were exposed to nickel. 34,54,71 S. mitis was found previously to induce CXCL8 in oral epithelial cells 72 In contrast to nickel, titanium suppressed S. mitis-induced cytokine secretion in RHS and had no influence on RHG, strongly indicating that titanium is inert (Figure 7). Indeed titanium implants have been reported to cause allergic manifestations in clinic, 26 but these findings are still questionable due to the limited in vivo studies and inconclusive results from in vitro studies.…”

Section: Discussionmentioning

confidence: 93%

“…Because TLR1, 2, 4, 5, and 6 are well-known host receptors recognizing bacterial ligands, TLR 3 is also reported to be involved in skin sensitization 53 as well as metal-induced skin and mucosa irritation reactivity, 54,55 and all these TLRs may play a role in allergic reactions, for example, in asthma, 56 we next determined the mRNA expression of TLR1-6 in order to gain more mechanistic understanding of the differences observed between RHS and RHG upon S. mitis and metal exposure. The mRNA expression of TLR2, 4, and 6 was undetectable in all conditions (data not shown).…”

Section: Influence Of S Mitis and Metal Co-exposure On Tlr Expressionmentioning

confidence: 99%

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Differential influence of Streptococcus mitis on host response to metals in reconstructed human skin and oral mucosa

et al. 2020

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Background: Skin and oral mucosa are continuously exposed to potential metal sensitizers while hosting abundant microbes, which may influence the host response to sensitizers. This host response may also be influenced by the route of exposure that is skin or oral mucosa, due to their different immune properties. Objective: Determine how commensal Streptococcus mitis influences the host response to nickel sulfate (sensitizer) and titanium(IV) bis(ammonium lactato) dihydroxide (questionable sensitizer) in reconstructed human skin (RHS) and gingiva (RHG). Methods: RHS/RHG was exposed to nickel or titanium, in the presence or absence of S. mitis for 24 hours. Histology, cytokine secretion, and Toll-like receptors (TLRs) expression were assessed. Results: S. mitis increased interleukin (IL)-6, CXCL8, CCL2, CCL5, and CCL20 secretion in RHS but not in RHG; co-application with nickel further increased cytokine secretion. In contrast, titanium suppressed S. mitis-induced cytokine secretion in RHS and had no influence on RHG. S. mitis and metals differentially regulated TLR1 and TLR4 in RHS, and predominantly TLR4 in RHG. Conclusion: Co-exposure of S. mitis and nickel resulted in a more potent innate immune response in RHS than in RHG, whereas titanium remained inert. These results indicate the important influence of commensal microbes and the route of exposure on the host's response to metals.

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Section: Discussionmentioning

confidence: 93%

Section: Influence Of S Mitis and Metal Co-exposure On Tlr Expressionmentioning

confidence: 99%

Differential influence of Streptococcus mitis on host response to metals in reconstructed human skin and oral mucosa

et al. 2020

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“…Figure 2 shows the chemical structure of several common gold compounds. Several common metals (such as gold, nickel, copper, and mercury) have been found to have the ability to stimulate innate immunity (Suzuki et al, 2011 ; Rachmawati et al, 2015a ). A series of in vitro and in vivo studies have shown that gold compounds can not only promote direct immune cell-mediated destruction, but also synergistic promote the T cell-based anticancer immunity cycle via DC (see Figure 3 ).…”

Section: Antitumor Immune Effects Of Gold Compoundsmentioning

confidence: 99%

Recent Advances of Gold Compounds in Anticancer Immunity

et al. 2020

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In recent years, gold compounds have gained more and more attentions in the design of new metal anticancer drugs. Numerous researches have reported that gold compounds, in addition to their widely studied cytotoxic antitumor effects, also reverse tumor immune escape and directly facilitate the functions of immune cells, leading to enhanced anticancer effects. This review mainly summarizes our current understandings of antitumor effects of gold drugs and their relationships with various aspects of antitumor immunity, including innate immunity, adaptive immunity, immunogenic cell death, and immune checkpoints, as well as their roles in adverse effects. Some recent examples of anticancer gold compounds are highlighted. The property of gold compounds is expected to combine with anticancer immunotherapy, such as immune checkpoint inhibitors, to develop new anticancer therapeutic strategies.

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“…For example, some metal ions are known to produce functional mimicry of pathogen-associated molecular patterns (PAMP) (Schmidt and Goebeler 2015). Gold ions have the capacity to bind and activate Toll-like receptor (TLR)-3, while nickel, cobalt, and palladium ions have the capacity to bind and activate human TLR-4 (Schmidt et al 2010; Rachmawati et al 2013, 2015). The subsequent induction of pro-inflammatory signaling generates the antigen nonspecific signals required for DC activation, promoting sensitization.…”

Section: Metals and Allergic Diseasementioning

confidence: 99%

Metal nanomaterials: Immune effects and implications of physicochemical properties on sensitization, elicitation, and exacerbation of allergic disease

Roach

Stefaniak

Roberts

2019

Journal of Immunotoxicology

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The recent surge in incorporation of metallic and metal oxide nanomaterials into consumer products and their corresponding use in occupational settings have raised concerns over the potential for metals to induce size-specific adverse toxicological effects. Although nano-metals have been shown to induce greater lung injury and inflammation than their larger metal counterparts, their size-related effects on the immune system and allergic disease remain largely unknown. This knowledge gap is particularly concerning since metals are historically recognized as common inducers of allergic contact dermatitis, occupational asthma, and allergic adjuvancy. The investigation into the potential for adverse immune effects following exposure to metal nanomaterials is becoming an area of scientific interest since these characteristically lightweight materials are easily aerosolized and inhaled, and their small size may allow for penetration of the skin, which may promote unique size-specific immune effects with implications for allergic disease. Additionally, alterations in physicochemical properties of metals in the nano-scale greatly influence their interactions with components of biological systems, potentially leading to implications for inducing or exacerbating allergic disease. Although some research has been directed toward addressing these concerns, many aspects of metal nanomaterial-induced immune effects remain unclear. Overall, more scientific knowledge exists in regards to the potential for metal nanomaterials to exacerbate allergic disease than to their potential to induce allergic disease. Furthermore, effects of metal nanomaterial exposure on respiratory allergy have been more thoroughly-characterized than their potential influence on dermal allergy. Current knowledge regarding metal nanomaterials and their potential to induce/ exacerbate dermal and respiratory allergy are summarized in this review. In addition, an examination of several remaining knowledge gaps and considerations for future studies is provided.

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Dental metal-induced innate reactivity in keratinocytes

Cited by 14 publications

References 39 publications

Differential influence of Streptococcus mitis on host response to metals in reconstructed human skin and oral mucosa

Differential influence of Streptococcus mitis on host response to metals in reconstructed human skin and oral mucosa

Recent Advances of Gold Compounds in Anticancer Immunity

Metal nanomaterials: Immune effects and implications of physicochemical properties on sensitization, elicitation, and exacerbation of allergic disease

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