Dental infections and serum inflammatory markers in patients with and without severe heart disease

Meurman, Jukka H.; Janket, Sok-Ja; Qvarnström, Markku; Nuutinen, Pekka

doi:10.1016/j.tripleo.2003.08.017

Cited by 44 publications

(42 citation statements)

References 36 publications

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“…In combination with other risk factors of this population like smoking, high blood pressure and increased BMI, periodontitis may at least in part contribute to the development of atherosclerosis in this population. Poor oral health conditions in patients suffering from coronary heart diseases compared to healthy subjects were shown by Meurman et al [12] In summary, we detected similar core bacterial members of the oral microbiota in patients and healthy controls. The oral cavity is a potential source for atherosclerotic plaqueassociated bacteria; however, any correlation between specific bacteria in the oral cavity and atherosclerosis were not found and the pathology of atherosclerosis may not be related to significant qualitative changes in oral microbiota.…”

Section: Discussionsupporting

confidence: 80%

16S rDNA-based metagenomic analysis of human oral plaque microbiota in patients with atherosclerosis and healthy controls

Ismail

Baetzner

Heuer

et al. 2012

Indian Journal of Medical Microbiology

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To address the question if an altered oral microbiota is associated with atherosclerosis. Twenty patients suffering from atherosclerosis and 10 controls were recruited. Clinical oral, medical and laboratory investigations were performed. Oral bacteria were collected and 16S rDNA was sequenced following Single strand conformation polymorphism.(SSCP) Probing pocket depths in patients were significantly elevated. The oral microbiota of patients and controls were dominated by Fusobacterium (16%/17%), Streptococcus (21%/14%), Prevotella (10%/12%), Enterococcus (12%/12%), Porphyromonas (8%/7%), TM7 (0%/7%) and Veillonella (6%/7%). Differences in diversity were not significant between groups. The pathology of atherosclerosis may not be related to significant qualitative changes of the oral microbiota.

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Section: Discussionsupporting

confidence: 80%

16S rDNA-based metagenomic analysis of human oral plaque microbiota in patients with atherosclerosis and healthy controls

Ismail

Baetzner

Heuer

et al. 2012

Indian Journal of Medical Microbiology

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“…59 Correlations between Fg levels and periodontal status have also been observed: Fg is found in settings where many putative periodontal pathogens are located and also participates in regulating inflammatory reactions in periodontal tissue. 60 In the present study, levels of hs-CRP and Fg were higher in CHD patients with chronic periodontitis than in those without chronic periodontitis, although only the increase in hs-CRP levels reached statistical significance.…”

Section: K Tang M Lin Y Wu Et Al Lipid and Cytokine Profiles In Chcontrasting

confidence: 59%

Alterations of Serum Lipid and Inflammatory Cytokine Profiles in Patients with Coronary Heart Disease and Chronic Periodontitis: A Pilot Study

Tang

Lin

et al. 2011

J Int Med Res

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Serum lipid and inflammatory cytokine profiles were assessed in 124 in-patients with coronary heart disease (CHD) (CHD group) and 43 inpatients with no evidence of CHD (control group). In all patients, research questionnaires and examinations of periodontal health were conducted and venous blood samples were analysed. Both groups were divided into two subgroups according to the presence or absence of chronic periodontitis in individual patients. The prevalence of chronic periodontitis was higher in patients from the CHD group than in the control group. Levels of total cholesterol, triglycerides, low-density lipoprotein, oxidized low-density lipoprotein, highsensitivity C-reactive protein, interleukin-6 and tumour necrosis factor-a were significantly higher in CHD patients with chronic periodontitis than in those without periodontitis. In conclusion, chronic periodontitis may be associated with CHD.

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“…Periodontal disease has been associated with increased risk of cardiovascular disease. 64,65 Severe gum disease can be associated with elevated CRP and may actually be a smoldering inflammatory state. Chronic inflammation may in turn injure vascular endothelium and be a precipitant in the development of cardiovascular disease.…”

Section: Inflammatory Conditions With Nutrition Implicationsmentioning

confidence: 99%

Inflammation as the Key Interface of the Medical and Nutrition Universes: A Provocative Examination of the Future of Clinical Nutrition and Medicine

Jensen

2006

J Parenter Enteral Nutr

115

106

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There has been tremendous interest in inflammation by researchers, the medical community, and the lay public. Modulation of injury response is felt to represent a tenuous balance of pro- and anti-inflammatory cytokines. Adverse outcomes may result from severe, sustained, or repeated bouts of inflammation. A critical observation is that nutrition support alone is inadequate to prevent muscle loss during active inflammation. It is necessary to take inflammation into consideration in conducting appropriate nutrition assessment, intervention, and monitoring. A host of medical conditions are actually inflammatory states that have important implications for nutrition care. Multifaceted interventions that may include anti-inflammatory diets, glycemic control, physical activity, appetite stimulants, anabolic agents, anti-inflammatory agents, anticytokines, and probiotics, will be necessary to blunt undesirable aspects of inflammatory response to preserve body cell mass and vital organ functions. Nutrition practitioners can seize this opportunity to be a part of the future medical team that brings highly individualized patient care to the bedside.

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Dental infections and serum inflammatory markers in patients with and without severe heart disease

Cited by 44 publications

References 36 publications

16S rDNA-based metagenomic analysis of human oral plaque microbiota in patients with atherosclerosis and healthy controls

16S rDNA-based metagenomic analysis of human oral plaque microbiota in patients with atherosclerosis and healthy controls

Alterations of Serum Lipid and Inflammatory Cytokine Profiles in Patients with Coronary Heart Disease and Chronic Periodontitis: A Pilot Study

Inflammation as the Key Interface of the Medical and Nutrition Universes: A Provocative Examination of the Future of Clinical Nutrition and Medicine

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