Dental infections and coronary atherosclerosis

Mattila, Kimmo; Valle, M; Nieminen, Markku S.; Valtonen, Ville; Hietaniemi, Katariina L.

doi:10.1016/0021-9150(93)90263-t

Cited by 268 publications

(209 citation statements)

References 29 publications

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“…The initial reports of positive associations, by Mattila et al from Finland, came from case-control studies of myocardial infarction 4 and coronary atherosclerosis. 5 Similar findings have been reported from other case-control studies of myocardial infarction 6,7 and stroke 8 and from cross-sectional studies of myocardial infarction, 4 stroke, 9 and cardiovascular disease (CHD, stroke, or claudication). 10 Although in general these reported associations remained statistically significant after adjustment for major confounders such as age, sex, smoking habit, and socioeconomic status, 10 the recognized limitations of case-control studies and the possibility of selective publication bias mandate caution when interpreting these results.…”

Section: See P 1095supporting

confidence: 82%

Dental Disease, Coronary Heart Disease and Stroke, and Inflammatory Markers

Lowe

2004

Circulation

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Section: See P 1095supporting

confidence: 82%

Dental Disease, Coronary Heart Disease and Stroke, and Inflammatory Markers

Lowe

2004

Circulation

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“…Many studies have demonstrated that CAD is liked to periodontal disease [3][4][5][6][7][8][9] . Periodontal pathogens have recently been identified in atherosclerotic lesion [10][11][12] and periodontal pathogens invase to human coronary cells [13] .…”

Section: Discussionmentioning

confidence: 99%

“…It seems this phenomenon becomes inflammatory [1] . Results of several cross-sectional [2,3] and casecontrol [4,5] studies have raised the possibility that persons with periodontal disease may have increased risk of cardiovascular disease. This relationship is difficult to validate because of the kind of study design and outcome of measurement of periodontal disease or infection [6] .…”

Section: Introductionmentioning

confidence: 99%

Periodontal Disease as a Risk Factor for Coronary Artery Disease

Najafi-Parizi¹,

Lori²

2005

American J. of Applied Sciences

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There are many risk factors for coronary artery disease (CAD) and periodontal disease (PDD) is a controversial risk factor. The aim of this study was to show the association between CAD and PDD. A case-control study was designed. Sixty one patients that CAD was confirm in them by coronary angiography compared with sixty one patients with normal angiography. PDD was evaluated by two indices, gingival index and periodontal disease index. Odds ratio was calculated for the risk of PDD for CAD. The results were shown no differences between groups about sex, age, educational level and occupation. The odds ratio of periodontal disease for CAD was 58 with CI95% (51-65). The relationship between tooth frequency and CAD was not statistically significant. Finding of the current study suggested that periodontal disease is the risk factor for CAD. However more clinical studies especially prospective longitudinal studies were recommended.

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“…Lactobacillus, Haemophilus influenzae, Streptococci pneumonia, viridans and nonhemolytic streptococci are a few of the oropharyngeal flora implicated in the development of atherosclerosis (Mattila et al 1993;Prasad, 2003a). In addition, Helicobacter pylori infection has been associated with atherosclerosis and MI.…”

Section: Other Pathogensmentioning

confidence: 99%

Homocysteine and Malondialdehyde as Predictors of Restenosis Following Percutaneous Coronary Intervention

et al. 2006

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Restenosis is one of the major adverse outcomes of Percutaneous CoronaryIntervention (PCI). Previous studies have shown conflicting reports for homocysteine as a predictor of restenosis following PCI. The conflicting reports may be due to oxidative factors (stimulation of polymorphonuclear leukocyte [PMNL]-induced reactive oxygen species generation, xanthine-xanthine oxidase, and arachidonic acid metabolism) other than homocysteine which could cause endothelial cell dysfunction leading to restenosis.Malondialdehyde (MDA), a lipid peroxidation product, is a marker for oxidative stress and is related to all oxidative factors. Therefore, it is possible that serum MDA may be a better predictor of restenosis than plasma homocysteine. The purpose of this study is to determine whether or not the pre-procedural serum MDA and plasma homocysteine levels are elevated in patients who develop restenosis post PCI.The study included fifty-one patients undergoing elective PCI who consented to participate in a protocol that was approved by the Ethics Committee of the University of Saskatchewan. Homocysteine and malondialdehyde were measured in the plasma and serum respectively. Blood samples were collected pre-procedural, 0 time, 8 hours, 24 hours, and 6 months post-procedure. Exercise tolerance tests were performed at two weeks, and six months post-procedure to determine if there was any evidence of restenosis.The results of the study showed that pre-procedural values of plasma homocysteine in the restenosis and non-restenosis groups were 10.37 ± 0.46 and 10.73 ± 0.49 respectively. These values were not significantly different (p=0.60) between the groups. The pre-procedural levels of plasma homocysteine were not significantly ii different (p=0.08) from the post-PCI values of those patients who did not develop restenosis at the 6-month time interval. However, the pre-procedural levels of plasma homocysteine were significantly different from the post-PCI values of those patients in the restenosis group at the 24hr (p=0.04) and 6-month (p=0.002) time intervals. In the restenosis group there was a significant increase (24%) after six months in the values of homocysteine from the pre-procedural levels. Thus, this indicates that restenosis is associated with higher post-PCI levels of homocysteine.The pre-procedural levels of serum MDA in the restenosis and non-restenosis groups were 0.124± 0.16 and 0.147± 0.02 respectively. There was no significant difference (p=0.60) between the two groups. There was also no significant difference The results suggest that pre-procedural levels of plasma homocysteine and serum MDA were not predictors of restenosis following PCI. However, the post-PCI sixmonth levels of both homocysteine and MDA are predictors of restenosis. Moreover, the post-PCI levels of MDA were better predictors of restenosis than the post-PCI levels of homocysteine because the increase in MDA levels were greater at six months than the rise in homocysteine levels at the same time interval.iii ACKNOWLEDGEMENTS

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Dental infections and coronary atherosclerosis

Cited by 268 publications

References 29 publications

Dental Disease, Coronary Heart Disease and Stroke, and Inflammatory Markers

Dental Disease, Coronary Heart Disease and Stroke, and Inflammatory Markers

Periodontal Disease as a Risk Factor for Coronary Artery Disease

Homocysteine and Malondialdehyde as Predictors of Restenosis Following Percutaneous Coronary Intervention

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