Periodontal Disease as a Risk Factor for Coronary Artery Disease

Najafi-Parizi, Gholamali; Lori, Ahmad

doi:10.3844/ajassp.2005.1526.1528

Cited by 3 publications

(2 citation statements)

References 14 publications

(16 reference statements)

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“…Factors such as low serum adiponectin (Shojaie et al, 2009) and annexin V levels (Shojaie et al, 2009), infectious diseases such as Mycoplasma pneumonia (Pourahmad et al, 2009), Periodontal Disease (Najafi-Parizi andLori, 2005) and Opium Addiction (Azimzade-Sarwar et al, 2005) are a part of involving factors in MI. Inflammation plays a pivotal role in atherosclerosis and coronary heart disease (Trepels et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

Cardiotrophin-1 in Patients with Acute Myocardial Infarction

Jahromi¹,

Shojaie²,

Madani³

2010

American Journal of Applied Sciences

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Problem statement: Myocardial infarction is the combined result of environmental and personal factors. Prothrombotic factors might play an important role in this phenomenon. Inflammation plays a pivotal role in atherosclerosis and coronary heart disease. Cardiotrophin-1 (CT-1), a member of the IL-6 family of cytokines, was identified as a growth factor for cardiac myocytes that induces cardiomyocyte hypertrophy and stimulates cardiac fibroblasts, protects myocytes from cell death. This study was designed to investigate whether plasma concentration of Cardiotrophin-1 (CT-1), in patients who had the first acute myocardial infarction and to analyze their relationship with traditional cardiovascular risk factors. Approach: This study was carried out on 45 patients with Acute Myocardial Infarction (AMI) in their first 24 h of admission as case group and 36 healthy matched individuals were studied as the control. Plasma level of cardiotrophin-1 was determined by enzymelinked immunosorbent assay and the results were compared. Results: Plasma CT-1 levels in the patients with AMI on admission 615.279±5.109 pmol L −1 were significantly higher than those in the control group 534.767±6.750 pmol L −1 (p = 0.001). Plasma CT-1 level was not correlated with diabetes mellitus, hyperlipidemia, sex, age and smoking. Conclusion: Our findings suggested that high plasma CT-1 level in patients with AMI is indicative of hypercoagulable state that is not related to the traditional cardiovascular risk factors.

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Section: Introductionmentioning

confidence: 99%

Cardiotrophin-1 in Patients with Acute Myocardial Infarction

Jahromi¹,

Shojaie²,

Madani³

2010

American Journal of Applied Sciences

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“…But many conditions increase risk of CHD, yet, through atherosclerosis. It seems this phenomenon becomes inflammatory (Najafi-Parizi and Lori, 2005). Therefore, the theory of "Focal infection" was introduced in 1990 supposing that inflammation was a cause in Pathogenesis of CHD.…”

Section: Introductionmentioning

confidence: 99%

Utilization of Specific Index for Measuring the Association between Periodontal Conditions and Coronary Artery Disease

Nader¹,

Mehdizadeh²

2010

Current Research in Dentistry

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Problem statement: There is increasing evidence that periodontal disease could play a role in the Progression of coronary heart disease although there are conflicting results about this association in the literature and the difference of used periodontal scoring systems among the studies might be a reason. The purpose of this study was to evaluate a specific scoring system Periodontal Index for Risk of Infectiousness (PIRI) in comparison with one of the classic periodontal indices Extent and Severity Index (ESI). Approach: A Total of 200 patients (100 candidate for bypass Surgery and 100 presumably healthy controls) were enrolled in this cross-sectional study age and sex matching were done for the two groups. PIRI and ESI were used to assess the periodontal status in both groups. Results: The average of attachment loss extent in CHD group was 94.77±13 and for severity: 4.47±1.36. The mean ESI scores was significantly higher in patients than in controls (p<0/0001) PIRI score showed that 87 patients in CHD group were in moderate group and 13 patients in severe group also PIRI scores between two groups, showed a significant difference (p = 0/01). A logistic regression model showed a association between both indices and coronary situation of patients. Conclusion: Our findings suggest that PIRI might be the best indicator for quantifying of subgingival surface exposure to microbial products and the risk of systemic consequences of periodontitis. Although it should be evaluated in other studies.

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