Dental enamel defects in celiac disease

Aine, L; Mäki, Markku; Collin, Pekka; Keyriläinen, O

doi:10.1111/j.1600-0714.1990.tb00834.x

Cited by 147 publications

(154 citation statements)

References 17 publications

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“…36 Dental enamel defects and aphthous stomatitis can suggest subclinical CD. 37,38 Sometimes, CD patients have a gluten-sensitive dysmotility involving the whole gastrointestinal tract, and the clinical expression may be dyspepsia, reflux, dysphagia or, more frequently, severe constipation. 39 Irritable bowel syndrome, common in the general population, can hide a condition of gluten-sensitive enteropathy.…”

Section: Introductionmentioning

confidence: 99%

Celiac disease: diagnostic criteria in progress

2011

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Until a few years ago, celiac disease (CD) was thought to be a rare food intolerance that was confined to childhood and characterized by severe malabsorption and flat intestinal mucosa. Currently, CD is regarded as an autoimmune disorder that is common in the general population (affecting 1 in 100 individuals), with possible onset at any age and with many possible presentations. The identification of CD is challenging because it can begin not only with diarrhea and weight loss but also with atypical gastrointestinal (constipation and recurrent abdominal pain) and extra-intestinal symptoms (anemia, raised transaminases, osteoporosis, recurrent miscarriages, aphthous stomatitis and associated autoimmune disorders), or it could be completely symptomless. Over the last 20 years, the diagnostic accuracy of serology for CD has progressively increased with the development of highly reliable tests, such as the detection of IgA tissue transglutaminase and antiendomysial and IgG antideamidated gliadin peptide antibodies. The routine use of antibody markers has allowed researchers to discover a very high number of 'borderline' cases, characterized by positive serology and mild intestinal lesions or normal small intestine architecture, which can be classified as potential CD. Therefore, it is evident that the 'old celiac disease' with flat mucosa is only a part of the spectrum of CD. It is possible that serology could identify CD in its early stages, before the appearance of severe intestinal damage. In cases with a positive serology but with mild or absent intestinal lesions, the detection of HLA-DQ2 and HLA-DQ8 can help reinforce or exclude the diagnosis of gluten sensitivity.

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Section: Introductionmentioning

confidence: 99%

Celiac disease: diagnostic criteria in progress

2011

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“…Because the clinical picture of dental enamel defects in CELIAC DISEASE patients may be diverse, a four-grade classification proposed by Aine et al [48] is widely used for the purpose of assessment [48] (Table 3). Table 3: Classification of dental enamel defects (by Aine et al [48]). …”

Section: Enamel Defectsmentioning

confidence: 99%

“…According to these authors, enamel defects in celiac disease patients should be present symmetrically and chronologically in the same anatomical groups (specific) of teeth in all quadrants of the dentition [48]. In contrast, enamel defects in healthy patients are nonspecific [50,29,31,[36][37][38].…”

Section: IVmentioning

confidence: 99%

The Effect of Celiac Disease on the Oral Cavity: A Review )

Al-Homaidhi

2018

JDHODT

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“…DED may include pitting, grooving and complete loss of enamel. Table 1 highlights DED classification and has been adapted from Aine et al (1990) 23 : Table 1 -Classification of DED 23 Grade I Defects in colour of enamel: single of multiple cream, yellow or brown opacities Grade II Slight structural defects: rough enamel surface, horizontal grooves, shallow pits Grade III Evident structural defects: deep horizontal grooves, large vertical pits Grade IV Severe structural defects: shape of tooth changed Table 2 Few scenarios that may be encountered by a GDP Scenario 1 A child presenting with isolated DED or delayed dentition or RAU or dental caries without any other oral manifestations and no history of GI involvement -referral to GMP not indicated Scenario 2…”

Section: Clinical Presentationmentioning

confidence: 99%

Coeliac disease in children – an update for general dental practitioners

et al. 2016

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Coeliac disease (CD) is an immune-mediated systemic disorder caused by ingestion of gluten found in wheat, rye and barley. It affects around 1% of children but 90% of cases are considered to remain undiagnosed. CD classically presents with gastrointestinal manifestations including diarrhoea, bloating, weight loss and abdominal pain, but extra-intestinal features (including oral and dental manifestations) are increasingly being reported. Dental and oral manifestations such as dental enamel defects, delayed eruption of teeth, recurrent aphthous ulcers are well recognized manifestations of CD. In patients with yet undiagnosed CD, these can sometimes be the only presenting features. Dentists have regular contact with well children, and therefore the visit to the dentist is an opportunity to suspect CD. When CD is suspected, Dental practitioners can liaise with the General Medical Practitioner to organise screening for coeliac disease. Positive serology will prompt onward referral to a paediatric gastroenterologist to confirm the diagnosis. The recent European Paediatric Gastroenterology Hepatology and Nutrition (ESPGHAN) guidelines have streamlined the diagnostic pathway for faster diagnosis of CD. Management involves strict adherence to a gluten free diet, which should lead to resolution of symptoms, recovery of intestinal mucosa and prevention of long-term complications associated with it. This article aims to describe CD, inform of recent changes to the diagnostic pathway and highlight the dental manifestations of the condition to equip Dental practitioners to aid early diagnosis and initiation of treatment for children with CD.

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Dental enamel defects in celiac disease

Cited by 147 publications

References 17 publications

Celiac disease: diagnostic criteria in progress

Celiac disease: diagnostic criteria in progress

The Effect of Celiac Disease on the Oral Cavity: A Review )

Coeliac disease in children – an update for general dental practitioners

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