Dental enamel defects in adult coeliac disease: Prevalence and correlation with symptoms and age at diagnosis

Trotta, Lucia; Biagi, Federico; Bianchi, Paola Ilaria; Marchese, A.; Vattiato, C.; Balduzzi, Davide; Collesano, Vittorio; Corazza, Gino Roberto

doi:10.1016/j.ejim.2013.03.007

Cited by 18 publications

(29 citation statements)

References 12 publications

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“…Trotta et al have observed a tendency for a more frequent occurrence of advanced lesions (of the 3 rd and 4 th degree) among adult patients suffering from classical celiac disease. However, the dependency was not statistically significant [19].…”

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confidence: 84%

“…Trotta et al have reported its ocurrence in as much 85.2% of adult patients [19]. Some authors suggest that there is a correlation between those changes and the age of patients [8,9,14].…”

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confidence: 99%

“…Developmental defects of the dental enamel are especially frequently observed [6][7][8][9][10][11][12][13][14][15][16][17][18][19]. Impairment of dental crowns mineralization may occur in numerous systemic diseases.…”

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confidence: 99%

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Celiac Disease and Its Impact on the Oral Health Status – Review of the Literature

B¹,

Herman²,

Kowalczyk−Zając³

et al. 2014

Adv Clin Exp Med

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The paper presents the most recent reports on celiac disease, especially its manifestations within the oral cavity. Particular attention should be paid to typical dental enamel defects with a various degree of advancement: discolorations, horizontal groves and pits, and even significant structural destruction causing the change of the dental crown. Symmetric location of defects within all dentition sections, and within the same anatomic groups of teeth (the most frequently: incisors and first permanent molars), is specific for celiac disease. The changes described above may be the only manifestation of celiac disease; therefore, in the case of their occurrence further studies towards gluten intolerance are recommended even when other symptoms are not present. In celiac patients, recurrent aphthae and other disorders of the oral mucosa such as ulceration, erythema, atrophic glossitis, as well as dryness and a burning sensation (particularly of the tongue) may be present, which may be caused by malnutrition. Delayed tooth eruption may also be a consequence of alimentary deficiency in celiac disease (Adv Clin Exp Med 2014, 23, 5, 675-681).

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confidence: 84%

“…Trotta et al have reported its ocurrence in as much 85.2% of adult patients [19]. Some authors suggest that there is a correlation between those changes and the age of patients [8,9,14].…”

mentioning

confidence: 99%

See 1 more Smart Citation

Celiac Disease and Its Impact on the Oral Health Status – Review of the Literature

B¹,

Herman²,

Kowalczyk−Zając³

et al. 2014

Adv Clin Exp Med

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“…Among oral manifestations, the two most common are recurrent aphthous stomatitis and dental enamel defects (DEDs) . DEDs are a common alteration in CD individuals and its prevalence ranges between 38% to over 80% .…”

Section: Introductionmentioning

confidence: 99%

“…DEDs are a common alteration in CD individuals and its prevalence ranges between 38% to over 80% . DEDs tend to present a symmetrical phenotype in all four hemiarches, in which the most commonly affected teeth are incisors and molars …”

Section: Introductionmentioning

confidence: 99%

Assessing the proposed association between DED and gluten‐free diet introduction in celiac children

Queiroz

Arid

Carvalho

et al. 2017

Special Care in Dentistry

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A strong association between celiac disease (CD) and dental enamel defects (DEDs) have been extensively reported, however, the nature of this relationship is still unclear. The aim of this study was to evaluate DEDs phenotype in CD individuals according to the time they were introduced to a gluten-free diet (GFD). Forty-five CD individuals were examined by a pediatric dentist. DEDs were classified according to the type of affected teeth. CD individuals were classified into two groups (with or without DEDs) and the differences between these groups were tested using chi-square or Fisher´s exact tests and t-test to compare differences between means. The Pearson coefficient test was used to evaluate the degree of the correlation between the age of GFD introduction and number of affected teeth. Individuals with MIH were introduced earlier to the GFD (p = 0.038). An association was also observed for molar DED (p = 0.013). In conclusion, our study suggested an association between a specific type of DED and the time that CD individuals were introduced to a GFD.

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Salivary proline‐rich proteins and gluten: Do structural similarities suggest a role in celiac disease?

Tian

Messana

Leffler

et al. 2015

Proteomics Clinical Apps

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Purpose Gluten proteins, the culprits in celiac disease (CD), show striking similarities in primary structure with human salivary proline-rich proteins (PRPs). Both are enriched in pro-line and glutamine residues that often occur consecutively in their sequences. We investigated potential differences in the spectrum of salivary PRPs in health and CD. Experimental design Stimulated salivary secretions were collected from CD patients, patients with refractory CD, patients with gastrointestinal complaints but no CD, and healthy controls. PRP isoforms/peptides were characterized by anionic and SDS-PAGE, PCR, and LC-ESI-MS. Results The gene frequencies of the acidic PRP isoforms PIF, Db, Pa, PRP1, and PRP2 did not differ between groups. At the protein level, PRPs peptides showed minor group differences, but these could not differentiate the CD and/or refractory CDs groups from the controls. Conclusions and clinical relevance This extensive study established that salivary PRPs, despite similarity to gluten proteins, show no apparent correlation with CD and thus will not serve as diagnostic markers for the disease. The structural basis for the tolerance to the gluten-like PRP proteins in CD is worthy of further exploration and may lead to the development of gluten-like analogs lacking immunogenicity that could be used therapeutically.

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Dental enamel defects in adult coeliac disease: Prevalence and correlation with symptoms and age at diagnosis

Cited by 18 publications

References 12 publications

Celiac Disease and Its Impact on the Oral Health Status – Review of the Literature

Celiac Disease and Its Impact on the Oral Health Status – Review of the Literature

Assessing the proposed association between DED and gluten‐free diet introduction in celiac children

Salivary proline‐rich proteins and gluten: Do structural similarities suggest a role in celiac disease?

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