Dental caries, <i>diabetes mellitus</i>, metabolic control and diabetes duration: A systematic review and meta‐analysis

Coelho, Ana; Amaro, Inês; Caramelo, Francisco; Paula, Anabela; Marto, Carlos Miguel; Ferreira, Manuel Marques; Botelho, Maria Filomena; Carrilho, Eunice

doi:10.1111/jerd.12562

Cited by 19 publications

(21 citation statements)

References 77 publications

(227 reference statements)

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“…However, diabetes mellitus was not associated with tooth extraction due to dental caries in the current study. Although some studies [7,8] have reported an association between diabetes mellitus and dental caries, others [6] have reported no association. The relationship between diabetes mellitus and dental caries is not as strong as that of diabetes mellitus and periodontal disease.…”

Section: Discussionmentioning

confidence: 97%

“…Coelho et al [6] indicated that several factors might be associated with dental caries in patients with diabetes mellitus, such as daily meal habits, salivary glucose, and low salivary flow. However, diabetes mellitus was not associated with tooth extraction due to dental caries in the current study.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, a bidirectional association was described between diabetes mellitus and periodontal disease [5]. Several studies have also reported an association between dental caries and diabetes mellitus [6][7][8]. De Lima et al [7] reported that dental caries was more prevalent among patients with diabetes mellitus than among healthy controls.…”

Section: Introductionmentioning

confidence: 99%

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Self-Reported Diabetes Mellitus and Tooth Extraction Due to Periodontal Disease and Dental Caries in the Japanese Population

Suzuki

Sugihara

Kamijo

et al. 2021

IJERPH

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Diabetes mellitus is closely related to oral health. We aimed to determine the relationship between diabetes mellitus and tooth extraction due to periodontal disease and dental caries. Japan’s second nationwide survey data collected from 4 June to 10 June 2018 was used to identify reasons for tooth extraction among patients aged > 40 years. General dentists collected information on patients who underwent tooth extraction procedures, and the presence of diabetes mellitus was determined through interviews. Multivariable logistic regression was performed to investigate the relationship between diabetes mellitus and the reasons for tooth extraction, including periodontal disease and dental caries. In total, 2345 dentists responded to the survey (response rate 44.8%). We analyzed data on 4625 extracted teeth from 3750 patients (1815 males and 1935 females). Among patients with self-reported diabetes mellitus, 55.4% had extractions due to periodontal disease compared to 46.7% of such extractions among those without self-reported diabetes mellitus. Self-reported diabetes mellitus was significantly associated with tooth extraction due to periodontal disease. No significant differences were observed in dental caries according to self-reported diabetes mellitus status. This study provides further evidence of a significant association between diabetes mellitus and tooth extraction due to periodontal disease.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Self-Reported Diabetes Mellitus and Tooth Extraction Due to Periodontal Disease and Dental Caries in the Japanese Population

Suzuki

Sugihara

Kamijo

et al. 2021

IJERPH

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“…Several studies have evaluated whether type 1 diabetes (T1D) increases caries susceptibility [ 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 ]. However, the results of studies that describe the association between diabetes and the incidence and intensity of caries are conflicting [ 17 , 18 , 19 ]. It has been reported that most patients with T1D have salivary dysfunction as well as alterations in biochemical and microbiological salivary composition when compared to healthy subjects [ 5 , 14 , 20 , 21 ].…”

Section: Introductionmentioning

confidence: 99%

“…This is confirmed by a recent meta-analysis, showing a high global prevalence of dental caries among children and adolescents with T1D [ 23 ]. Further research on the risk of dental caries is necessary to maximize preventive measures and ensure optimal oral health for such vulnerable patients [ 18 , 19 , 24 ].…”

Section: Introductionmentioning

confidence: 99%

Downregulation of Salivary Proteins, Protective against Dental Caries, in Type 1 Diabetes

et al. 2021

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Saliva, an essential oral secretion involved in protecting the oral cavity’s hard and soft tissues, is readily available and straightforward to collect. Recent studies have analyzed the salivary proteome in children and adolescents with extensive carious lesions to identify diagnostic and prognostic biomarkers. The current study aimed to investigate saliva’s diagnostic ability through proteomics to detect the potential differential expression of proteins specific for the occurrence of carious lesions. For this study, we performed bioinformatics and functional analysis of proteomic datasets, previously examined by our group, from samples of adolescents with regulated and unregulated type 1 diabetes, as they compare with healthy controls. Among the differentially expressed proteins relevant to caries pathology, alpha-amylase 2B, beta-defensin 4A, BPI fold containing family B member 2, protein S100-A7, mucin 5B, statherin, salivary proline-rich protein 2, and interleukin 36 gamma were significantly downregulated in poorly-controlled patients compared to healthy subjects. In addition, significant biological pathways (defense response to the bacterium, beta-defensin activity, proline-rich protein activity, oxygen binding, calcium binding, and glycosylation) were deregulated in this comparison, highlighting specific molecular characteristics in the cariogenic process. This analysis contributes to a better understanding of the mechanisms involved in caries vulnerability in adolescents with unregulated diabetes.

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Caries‐related salivary parameters and oral microbial flora in patients with type 1 diabetes: A meta‐analysis

Ömer

Soğukpınar

Pertek

et al. 2022

Diabetes Metabolism Res

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Objectives: This study aimed to conduct a meta-analysis by synthesising the outcomes of studies that investigated the relationship between type 1 diabetes (T1D) and salivary flow rate (SFR), salivary pH (SpH), salivary buffer capacity (SBC), streptococcus Mutans (SM), and lactobacillus (LB) counts. Material and Methods:The PRISMA statement guide was followed for the metaanalysis. Electronic databases were searched, and study selection and data collection processes were performed. The risks of bias in individual studies and across studies were assessed. Mean differences (MD) and Odds Ratio (OR) were used to measure the effect estimates in the comparisons.Results: 29 studies were included in the qualitative and quantitative syntheses. Significantly higher SFR (MD = −0.22, CI: −0.26, −0.18; p < 0.001) and SpH (MD = −0.59, CI: −0.81, −0.36; p < 0.001) were observed in the healthy individuals than T1D individuals. No significant difference was observed among groups in terms of SBC (MD = 0.10, CI: −0.46,0.66; p = 0.73). An increased odds ratio of SM counts were observed regarding the T1D (OR = 3.09, 95% CI: 1.16, 8.20; p = 0.02). No association was found between LB counts and T1D (OR = 2.15, 95% CI: 0.38, 11.98; p = 0.38).Conclusions: Subjects with T1D have a significantly lesser SFR and SpH than healthy individuals. But no significant difference is available in terms of SBC. Lower SM counts were observed in individuals with T1D, while no association was observed regarding LB counts. The tendency to dental caries is more likely in subjects with T1D due to lower SFR, SpH, and higher SM.

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Dental caries, diabetes mellitus, metabolic control and diabetes duration: A systematic review and meta‐analysis

Cited by 19 publications

References 77 publications

Self-Reported Diabetes Mellitus and Tooth Extraction Due to Periodontal Disease and Dental Caries in the Japanese Population

Self-Reported Diabetes Mellitus and Tooth Extraction Due to Periodontal Disease and Dental Caries in the Japanese Population

Downregulation of Salivary Proteins, Protective against Dental Caries, in Type 1 Diabetes

Caries‐related salivary parameters and oral microbial flora in patients with type 1 diabetes: A meta‐analysis

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