“…First, a thin removable layer formed by salivary biopolymers and various proteins appears, called “acquired” or initial pellicle, followed by primary bacterial colonizers, usually aerobic and facultative anaerobic gram-positive coccoids, such as different Streptococcus species (e.g., S. sanguinis , S. salivarius , S. mitis , S. oralis ) [9, 10]. This initial colonization together with subsequent deposition of protective extracellular matrices creates required preconditions for the successive incorporation of secondary microorganisms, especially anaerobic gram-negative coccoids and rods [9–11]. Depending on the bacterial composition and amount of growing biofilm, inflammatory reactions in the periodontal and peri-implant soft and hard tissues occur, which can lead in worst case to progressive bone resorption and early implant failure [7, 12–15].…”