Dental applications of induced pluripotent stem cells and their derivatives

Gao, Pan; Liu, Shan; Wang, Xiaoyi; Ikeya, Motoji

doi:10.1016/j.jdsr.2022.03.002

Cited by 4 publications

(1 citation statement)

References 130 publications

(147 reference statements)

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“…However, reprogramming is technically complex and resource intensive. Efficient differentiation and purification protocols are needed to convert iPSCs into gingival lineages while avoiding tumorigenic risks from residual undifferentiated cells [23]. The functional capabilities of iPSCderived cells also remain to be fully characterized.…”

Section: Induced Pluripotent Stem Cellsmentioning

confidence: 99%

Regenerative Approaches in Gingival Tissue Engineering

H.S.A. Alyafei,

Anil

2024

Dentistry

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Gingival tissue engineering aims to regenerate damaged or diseased gingival tissues by applying biomaterials, growth factors, and stem cells. This chapter explores advancements and strategies in gingival tissue engineering. It begins by introducing the goals and anatomy/physiology of the gingiva. Biomaterial selection and design for gingival scaffolds and delivery methods for bioactive molecules to stimulate tissue growth are discussed. Stem cells are highlighted for their role in gingival regeneration - their isolation, characterization, and differentiation. Strategies like cell-based approaches, scaffold-free techniques, and hybrids combining cells, scaffolds, and growth factors are outlined. Preclinical and clinical studies assessing treatment safety/efficacy and methods to evaluate outcomes are reviewed. Challenges around improving cell viability, integration, and function are examined. Future directions focus on addressing these challenges. Ethical considerations and regulatory aspects are addressed to ensure responsible translation into clinical practice. This chapter provides insights into the current state and prospects of regenerative approaches in gingival tissue engineering, including their potential to impact gingival disease treatment and oral health promotion.

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Section: Induced Pluripotent Stem Cellsmentioning

confidence: 99%

Regenerative Approaches in Gingival Tissue Engineering

H.S.A. Alyafei,

Anil

2024

Dentistry

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Application of mesenchymal stem/stromal cells in periodontal regeneration: Opportunities and challenges

Gao,

Kajiya,

Motoike

et al. 2024

Japanese Dental Science Review

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Induced pluripotent stem cells: A game-changer in dentistry’s regenerative landscape

Ahmed,

Seth,

Goyal

et al. 2024

JCB

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In recent years, induced pluripotent stem cells (iPSCs) have emerged as a transformative force in regenerative medicine, offering unprecedented opportunities for advancements in various fields. This review explores the revolutionary impact of iPSCs specifically within the realm of dentistry, where regenerative strategies are increasingly sought to address oral and craniofacial tissue defects. iPSCs, derived from somatic cells through reprogramming, exhibit pluripotency and can differentiate into various cell types, including dental-specific lineages such as odontoblasts, ameloblasts, and osteoblasts. The application of iPSCs in dentistry holds immense promise for tissue repair, regeneration, and disease modelling. This review delves into the key aspects of iPSC-based approaches in dental research, covering topics such as tooth regeneration, periodontal tissue engineering, and craniofacial defect repair. We discuss the challenges and advancements in iPSC technology, emphasizing the potential for personalized regenerative therapies tailored to individual patients.

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Dental applications of induced pluripotent stem cells and their derivatives

Cited by 4 publications

References 130 publications

Regenerative Approaches in Gingival Tissue Engineering

Regenerative Approaches in Gingival Tissue Engineering

Application of mesenchymal stem/stromal cells in periodontal regeneration: Opportunities and challenges

Induced pluripotent stem cells: A game-changer in dentistry’s regenerative landscape

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