Application of mesenchymal stem/stromal cells in periodontal regeneration: Opportunities and challenges

Gao, Pan; Kajiya, Mikihito; Motoike, Souta; Ikeya, Makoto; Yang, Jingmei

doi:10.1016/j.jdsr.2024.01.001

Cited by 5 publications

(4 citation statements)

References 164 publications

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“…Conventional periodontal bone grafting or bone substitute implantation surgery comprises the transplantation of bone or substitute materials to address alveolar bone defects resulting from periodontitis. These surgeries aim to stimulate new bone formation, repair bone defects, restore the anatomical shape of the alveolar bone, and achieve optimal periodontal tissue regeneration ( Gao et al, 2024a ). Nevertheless, this method is subject to numerous influencing factors and may not consistently yield satisfactory outcomes in periodontal tissue regeneration and bone defect repair.…”

Section: Introductionmentioning

confidence: 99%

Emerging roles of hydrogel in promoting periodontal tissue regeneration and repairing bone defect

Guo,

Dong,

Wang

2024

Front. Bioeng. Biotechnol.

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Periodontal disease is the most common type of oral disease. Periodontal bone defect is the clinical outcome of advanced periodontal disease, which seriously affects the quality of life of patients. Promoting periodontal tissue regeneration and repairing periodontal bone defects is the ultimate treatment goal for periodontal disease, but the means and methods are very limited. Hydrogels are a class of highly hydrophilic polymer networks, and their good biocompatibility has made them a popular research material in the field of oral medicine in recent years. This paper reviews the current mainstream types and characteristics of hydrogels, and summarizes the relevant basic research on hydrogels in promoting periodontal tissue regeneration and bone defect repair in recent years. The possible mechanisms of action and efficacy evaluation are discussed in depth, and the application prospects are also discussed.

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Section: Introductionmentioning

confidence: 99%

Emerging roles of hydrogel in promoting periodontal tissue regeneration and repairing bone defect

Guo,

Dong,

Wang

2024

Front. Bioeng. Biotechnol.

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“…When compared to biomaterials, which are scaffolds characterized by unique chemical, mechanical, and biological properties, mainly osteoinductivity and osteoconductivity [21], cell therapy relies on replenishing and/or empowering the inner healing body potential [22,23]. In recent years, cell regeneration therapy has been introduced in many areas of medicine, such as cardiology, neurology, or traumatology [24,25], as well as for the treatment of orofacial dystrophies, diabetic problems, and autoimmune diseases [26,27].…”

Section: Introductionmentioning

confidence: 99%

“…Many intraoral and dental sources of MSCs are available, for example, dental pulp, periodontal ligament, bone marrow from alveolar bone, dental follicle, gingival connective tissue, or apical papilla [33][34][35][36]. In virtue of their self-renewal, multipotentiality, immunomodulation, and tissue regeneration capacities, MSCs can promote the growth of various periodontal tissues, like alveolar bones, root cementum, and periodontal ligaments, even in situations with low intrinsic potential [23,[37][38][39][40][41]. A recent study assessed periodontal regenerative approaches in animal models, observing that mesenchymal stem cells used alone or mixed with other biomaterials, such as bovine bone, beta-tricalcium phosphate, or platelet-rich plasma, offered better regenerative outcomes than those of the group with biomaterials alone [42].…”

Section: Introductionmentioning

confidence: 99%

Orally Derived Stem Cell-Based Therapy in Periodontal Regeneration: A Systematic Review and Meta-Analysis of Randomized Clinical Studies

Campagna,

Baima,

Romano

et al. 2024

Dentistry Journal

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The present systematic review was performed to assess the application of orally derived stem cells in periodontal regenerative therapy, and because of this, the following PICO question was proposed: “In patients with periodontitis, can the adjunctive use of orally derived stem cells provide additional clinical and radiographic benefits for periodontal regeneration?”. Randomized clinical studies were electronically and manually searched up until December 2023. Quantitative analyses were performed with the aim of evaluating the mean differences (MDs) between the treatment and control groups in terms of clinical attachment level (CAL) gain, probing pocket depth (PPD) reduction, gingival recession (GR), and radiographic bone gain (RBG) using random effect models. A total of seven studies were selected for the systematic review. Meta-analyses excluding studies with a high risk of bias highlighted a non-statistically significant result for the use of stem cells when compared to the control groups in terms of CAL gain [MD = 1.05; 95% CI (−0.88, 2.97) p = 0.29] and PPD reduction [MD = 1.32; 95% CI (−0.25, 2.88) p = 0.10]. The same also applied to GR [MD = −0.08; 95% CI (−0.79, 0.63) p = 0.83] and RBG [MD = 0.50; 95% CI (−0.88, 1.88) p = 0.48]. Based on the high heterogeneity, there is not enough evidence to consider the adjunctive application of orally derived mesenchymal stem cells as a preferential approach for periodontal regenerative treatment, as compared to standard procedures.

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“…Stem cells are crucial for periodontal tissue engineering due to their self-renewal capability and potential to differentiate into various cell types (Iwasaki et al, 2022). Stem cells for periodontal tissue are often derived from dental pulp, bone marrow mesenchymal stem cells, and PDLSCs (Gao et al, 2024), which can differentiate into specific periodontal cells such as osteoblasts and fibroblasts, aiding in tissue regeneration. Growth factors play a vital role in regulating cell behavior and promoting cell migration, proliferation, differentiation, and neovascularization in periodontal tissue regeneration (Kale et al, 2022).…”

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confidence: 99%

Hydrogels promote periodontal regeneration

Sun,

Luan,

Dong

2024

Front. Bioeng. Biotechnol.

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Periodontal defects involve the damage and loss of periodontal tissue, primarily caused by periodontitis. This inflammatory disease, resulting from various factors, can lead to irreversible harm to the tissues supporting the teeth if not treated effectively, potentially resulting in tooth loss or loosening. Such outcomes significantly impact a patient’s facial appearance and their ability to eat and speak. Current clinical treatments for periodontitis, including surgery, root planing, and various types of curettage, as well as local antibiotic injections, aim to mitigate symptoms and halt disease progression. However, these methods fall short of fully restoring the original structure and functionality of the affected tissue, due to the complex and deep structure of periodontal pockets and the intricate nature of the supporting tissue. To overcome these limitations, numerous biomaterials have been explored for periodontal tissue regeneration, with hydrogels being particularly noteworthy. Hydrogels are favored in research for their exceptional absorption capacity, biodegradability, and tunable mechanical properties. They have shown promise as barrier membranes, scaffolds, carriers for cell transplantation and drug delivery systems in periodontal regeneration therapy. The review concludes by discussing the ongoing challenges and future prospects for hydrogel applications in periodontal treatment.

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Application of mesenchymal stem/stromal cells in periodontal regeneration: Opportunities and challenges

Cited by 5 publications

References 164 publications

Emerging roles of hydrogel in promoting periodontal tissue regeneration and repairing bone defect

Emerging roles of hydrogel in promoting periodontal tissue regeneration and repairing bone defect

Orally Derived Stem Cell-Based Therapy in Periodontal Regeneration: A Systematic Review and Meta-Analysis of Randomized Clinical Studies

Hydrogels promote periodontal regeneration

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