Dental Anomalies in Children Born with Clefts: A Case-Control Study

Pedro, Rafael de Lima; Faria, Marcelo Daniel Brito; Costa, Marcelo de Castro; Vieira, Alexandre R.

doi:10.1597/10-067

Cited by 21 publications

(37 citation statements)

References 32 publications

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“…In current literature, tooth agenesis is also reported as the most frequent dental anomaly among cleft patients [3–7]. Interestingly, in the CL + P B group, the frequency of tooth agenesis was significantly higher among males.…”

Section: Discussionmentioning

confidence: 94%

“…The most frequent dental anomaly among cleft patients is tooth agenesis [3–7]. The occurrence of tooth agenesis among cleft patients is markedly increased in comparison to the general, non-cleft population [3, 6–11].…”

Section: Introductionmentioning

confidence: 99%

“…The occurrence of tooth agenesis among cleft patients is markedly increased in comparison to the general, non-cleft population [3, 6–11]. Additionally, dental anomalies appear more commonly in the cleft rather than the non-cleft area [4, 10, 12–14].…”

Section: Introductionmentioning

confidence: 99%

“…Still, the lateral incisor is reported as the most frequently missing tooth in cleft patients [3, 6, 13, 15, 16]. Also, according to a recent study, the prevalence of lateral incisor agenesis increases in respect to the severity of the cleft [16].…”

Section: Introductionmentioning

confidence: 99%

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A cross-sectional analysis of the prevalence of tooth agenesis and structural dental anomalies in association with cleft type in non-syndromic oral cleft patients

et al. 2017

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BackgroundThe aim of this study was to investigate the prevalence of tooth agenesis, microdontia, and tooth malformation among non-syndromic oral cleft patients and their potential association with cleft type and gender.MethodsIntraoral records and radiographs of 154 patients (97 males and 57 females) were examined. The variables assessed were tooth agenesis, microdontia, dental malformations, and cleft types. The statistics included chi-square and Fisher’s exact tests as well as logistic regression to assess any mutual effects of gender and cleft type on the dental variables.ResultsTooth agenesis occurred in 50% of the sample and microdontia in 18%. Non-statistically significant odds ratios for the association of gender and cleft type with tooth agenesis were obtained. Tooth agenesis was substantially higher at the unilateral right CL + P and the bilateral CL + P in quadrant 1 and at the unilateral left CL + P and bilateral CL + P in quadrant 2. It was also higher, at the isolated cleft palate (CP) in quadrants 3 and 4. These results were attributed to teeth 22 (31.8%) and 12 (21.6%) in the maxilla and to teeth 35 (6.1%) and 45 (5.4%) in the mandible. In unilateral CL + P patients, the cleft quadrant that presented tooth agenesis was associated with the side of the cleft.ConclusionsInterdisciplinary treatment of the oral cleft patients should take into consideration the high prevalence of tooth agenesis and their association with the different cleft types. The most frequently affected teeth by cleft are by far the upper lateral incisors. Results indicate that tooth agenesis appears to be a genetically controlled anomaly related to the orofacial cleft development through various genetic links and not caused by the cleft disruptive process.

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Section: Discussionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A cross-sectional analysis of the prevalence of tooth agenesis and structural dental anomalies in association with cleft type in non-syndromic oral cleft patients

et al. 2017

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“…Our results agree with these findings. Although the occurrence of tooth malposition could be explained as a conse-quence of plastic surgery for repair of the oral clefts, which can affect the development of maxillary bone resulting in less space in the upper arch for normal eruption of teeth [23], it is interesting to mention that the higher incidence of this dental anomaly occurred in the mandible and not the maxilla. Here our results are similar to those found in the literature, but the oc-currence of CL isolated was equal in both genders.…”

Section: Discussionmentioning

confidence: 99%

Tooth malposition in patients with cleft lip and/or palate in a Brazilian population

Filho

Dias

Martelli³

et al. 2015

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The purpose of the present study was to evaluate the prevalence of teeth malposition (rotated) in Brazilian patients with oral clefts and to contribute to the definition of subphenotypes. This study included 317 patients with nonsyndromic cleft lip with or without cleft palate. Tooth malposition was assessed clinically, through radiographs, and medical history records for each individual. Only teeth malpositions outside the area of the clefts were included. Comparisons were assessed by cross-tabulation and standard chi-square test, and statistical significance was set at p≤0.05. Cleft lip and palate was more prevalent in males, while cleft palate was more common in females. Regarding the presence of tooth malposition, of the 317 patients, 92 (29.02%) had at least one tooth with the dental anomaly. Tooth malposition was more common in patients with cleft lip and palate (16.1%), followed by, respectively, cleft palate (6.9%) and cleft lip (6%) (p=0.112). The highest occurrence of tooth malposition was in the mandible and involved the canines (p<0.01). Few studies have investigated the prevalence of tooth malposition in individuals with nonsyndromic cleft lip with or without cleft palate. Our results confirmed the highest occurrence of dental anomalies, particularly tooth malposition, in patients with oral clefts. Our findings also highlight that there was a higher occurrence of this condition in the mandible and not the maxilla.

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Tooth agenesis in German orthodontic patients with non-syndromic craniofacial disorder: a retrospective evaluation of panoramic radiographs

et al. 2022

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Objectives The study objective was to evaluate the tooth agenesis in German orthodontic patients with non-syndromic cleft lip and/or palate and Robin sequence compared to a control group without craniofacial disorder. Materials/methods A total of 108 panoramic radiographs were examined using the binary system of Tooth Agenesis Code (TAC) (excluding the third molar). Patients were divided into the craniofacial disorder group 1 (n = 43) and the healthy control group 2 (n = 65). Parameters such as skeletal class malformation, sex, localization of the cleft, craniofacial disorder, and interobserver reliability were assessed. Results Permanent tooth agenesis was observed in 44% of group 1 and 14% in group 2 with a statistically significant higher prevalence (p = 0.00162 (χ2)). Fourteen different TAC patterns were observed in group 1, ten of these occurring only once in separate patients. The distribution of the TAC codes in group 2 showed nine different possibilities of TAC code patterns; seven TACs were unique. In group 1, the most frequently absent teeth were the maxillary lateral incisor of the left side (30%); in group 2, the second premolar of the lower jaw on the right side (9%). Male patients with craniofacial disorder showed a higher percentage of tooth agenesis than female. Conclusion The data presented here shows a statistically significant higher prevalence of tooth agenesis in German patients with non-syndromic craniofacial disorder. Clinical relevance Radiographic evaluation enables the diagnosis of tooth agenesis. Recognizing early on the higher prevalence of tooth agenesis in patients exhibiting a craniofacial disorder is an important issue when developing long-term and comprehensive interdisciplinary treatment.

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Dental Anomalies in Children Born with Clefts: A Case-Control Study

Abstract: The higher prevalence of dental anomalies, especially number anomalies, opposite the cleft area, in individuals born with cleft lip and/or palate is the most common associated dental anomaly outside the cleft area.

Cited by 21 publications

References 32 publications

A cross-sectional analysis of the prevalence of tooth agenesis and structural dental anomalies in association with cleft type in non-syndromic oral cleft patients

A cross-sectional analysis of the prevalence of tooth agenesis and structural dental anomalies in association with cleft type in non-syndromic oral cleft patients

Tooth malposition in patients with cleft lip and/or palate in a Brazilian population

Tooth agenesis in German orthodontic patients with non-syndromic craniofacial disorder: a retrospective evaluation of panoramic radiographs

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