Dental agenesis patterns of permanent teeth in Apert syndrome

Stavropoulos, Dimitrios; Bartzela, Theodosia; Bronkhorst, Ewald M.; Mohlin, Bengt; Hagberg, Catharina

doi:10.1111/j.1600-0722.2011.00821.x

Cited by 27 publications

(28 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…When dental agenesis occurred, the remaining primary teeth were used to calculate dental arch dimensions. Maxillary lateral incisors and mandibular second premolars were the most frequently missing teeth in all three groups (6)(7)(8), although were more prevalent in syndromic patients. The arch development changes, in control subjects, for dental arch width, depth, and length, were comparable with those reported in the literature (9,11,12,14,17).…”

Section: Discussionmentioning

confidence: 88%

“…Abnormal arch development in syndromes where ceased growth does not reach its full potential is very easily picked up compared with normal arch development. In patients without any surgical or orthodontic treatment in the midface or mandible, or dental extractions, Crouzon or Apert syndrome showed a higher prevalence of dental agenesis, excluding third molars, compared with healthy controls (6)(7)(8). Dental agenesis may account for smaller dental arch dimensions in syndromic patients.…”

Section: Discussionmentioning

confidence: 93%

See 1 more Smart Citation

A longitudinal study of dental arch morphology in children with the syndrome of Crouzon or Apert

Reitsma

Elmi

Ongkosuwito

et al. 2013

European J Oral Sciences

View full text Add to dashboard Cite

The aim of this study was to compare changes in dental arch morphology between patients with Crouzon syndrome or Apert syndrome and controls. Children between 4 and 14 yr of age with Crouzon syndrome (n = 40) or Apert syndrome (n = 28) were compared with non-syndromic controls (n = 457) in terms of arch widths, depths, and length dimensions. Multilevel statistical modeling techniques were used to evaluate changes over time. Dental arch dimensions were found to be smaller in patients with Crouzon syndrome or Apert syndrome compared with control subjects. Maxillary intercanine width for patients with Apert syndrome were increased, whilst other arch width variables showed no change. Patients with Crouzon syndrome showed increases in maxillary intercanine width, whilst intermolar width showed no change over time. Dental arch dimensions in syndromic patients were thus found to be consistently smaller than in control subjects between 4 and 14 yr of age, implying that patients with Crouzon syndrome and Apert syndrome had a diminished growth potential.

show abstract

Section: Discussionmentioning

confidence: 88%

Section: Discussionmentioning

confidence: 93%

A longitudinal study of dental arch morphology in children with the syndrome of Crouzon or Apert

Reitsma

Elmi

Ongkosuwito

et al. 2013

European J Oral Sciences

View full text Add to dashboard Cite

show abstract

“…Of nine patients in a study of Apert syndrome with panoramic radiographs, two had a single ST in the anterior maxillary area [DalbenGda et al, ]. There was also negative evidence, for example, Stavropoulos et al [] evaluated serial panoramic radiographs for 26 patients with Crouzon syndrome, and 23 with Apert syndrome. While he extensively evaluated tooth agenesis, ST were not mentioned.…”

Section: Exclusions Of Commonly Cited Syndromesmentioning

confidence: 99%

Syndromes with supernumerary teeth

Lubinsky

Kantaputra

2016

American J of Med Genetics Pt A

View full text Add to dashboard Cite

While most supernumerary teeth are idiopathic, they can be associated with a number of Mendelian syndromes. However, this can also be a coincidental finding, since supernumerary teeth occur in 6% or more of the normal population. To better define this relationship, we analyzed the evidence for specific associations. We excluded conditions with a single affected patient reported, supernumerary teeth adjacent to clefts or other forms of alveolar disruption (as secondary rather than primary findings), and natal teeth, which can involve premature eruption of a normal tooth. Since, the cause of supernumerary teeth shows considerable heterogeneity, certain findings are less likely to be coincidental, such as five or more supernumerary teeth in a single patient, or locations outside of the premaxilla. We found only eight genetic syndromes with strong evidence for an association: cleidocranial dysplasia; familial adenomatous polyposis; trichorhinophalangeal syndrome, type I; Rubinstein–Taybi syndrome; Nance–Horan syndrome; Opitz BBB/G syndrome; oculofaciocardiodental syndrome; and autosomal dominant Robinow syndrome. There is also suggestive evidence of an association with two uncommon disorders, Kreiborg–Pakistani syndrome (craniosynostosis and dental anomalies), and insulin‐resistant diabetes mellitus with acanthosisnigricans. An association of a Mendelian disorder with a low frequency manifestation of supernumerary teeth is difficult to exclude without large numbers, but several commonly cited syndromes lacked evidence for clear association, including Hallermann–Streiff syndrome, Fabry disease, Ehlers–Danlos syndrome, Apert and Crouzon syndromes, Zimmermann–Laband syndrome, and Ellis–van Creveld syndrome. © 2016 Wiley Periodicals, Inc.

show abstract

“…Syndromic tooth agenesis is associated with various systemic conditions or syndromes (Table). 2,5,[7][8][9] Patients with syndromic tooth agenesis may have other concurrent dental anomalies such as microdontia, short roots, dental impactions, delayed formation of teeth, delayed eruption, transposition of canines and premolars, taurodontism, and enamel hypoplasia. 5 Ectodermal dysplasia, cleft lip, cleft palate, Down syndrome, and Van der Woude syndrome are commonly occurring syndromes with tooth agenesis as a feature.…”

Section: Introductionmentioning

confidence: 99%

Diagnosis of Tooth Agenesis in Childhood and Risk for Neoplasms in Adulthood

Ritwik

Patterson

2018

TOJ

View full text Add to dashboard Cite

Background: Tooth agenesis, the congenital absence of one or more teeth, can be diagnosed in children in the first decade of life. Tooth agenesis is a phenotypic feature of conditions such as ectodermal dysplasia, cleft lip, cleft palate, Down syndrome, and Van der Woude syndrome. Tooth agenesis can also be nonsyndromic. Studies have shown an association between the genetic determinants of nonsyndromic tooth agenesis and neoplasms in adulthood. Methods: This review of the implications of tooth agenesis as a risk indicator for neoplasms in adulthood is based on a search of PubMed to identify published case series, case reports, and review articles. The reference articles were manually searched. The search was limited to articles published in the English language. Results: Neoplasms reported in patients with tooth agenesis include colorectal neoplasms and epithelial ovarian cancer, as well as family histories of breast cancer, prostate cancer, and cancers of the brain and nervous system. Conclusion: Although odontogenesis and tumorigenesis may seem to be unrelated processes, the clinical association between the two highlights the overlap of genetic determinants and molecular pathways. Tooth agenesis can be diagnosed during childhood and should be considered a marker for risk of neoplasms in adulthood. Healthcare providers should identify tooth agenesis and provide appropriate anticipatory guidance.Tooth agenesis can be classified based on the number of congenitally missing teeth. Hypodontia refers to the absence of fewer than 6 teeth (not including third molars). 5,6

show abstract

Dental agenesis patterns of permanent teeth in Apert syndrome

Cited by 27 publications

References 25 publications

A longitudinal study of dental arch morphology in children with the syndrome of Crouzon or Apert

A longitudinal study of dental arch morphology in children with the syndrome of Crouzon or Apert

Syndromes with supernumerary teeth

Diagnosis of Tooth Agenesis in Childhood and Risk for Neoplasms in Adulthood

Contact Info

Product

Resources

About