Densitometry of Choroidal Vessels in Eyes With and Without Central Serous Chorioretinopathy by Wide-Field Indocyanine Green Angiography

Hirahara, Shuichiro; Yasukawa, Tsutomu; Kominami, Aoi; Nozaki, Miho; Ogura, Yuichiro

doi:10.1016/j.ajo.2016.03.040

Cited by 40 publications

(31 citation statements)

References 45 publications

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“…Recently developed wide-field fluorescein angiography (WFFA; Optos200Tx and Optos California, Optos DLC, Dunfermline, UK) has enabled the evaluation of wider retinal peripheral lesions in several retinal diseases [1][2][3]. It has been reported that peripheral lesions are associated with increased risk of diabetic retinopathy progression [1].…”

Section: Introductionmentioning

confidence: 99%

Peripheral Microvascular Abnormalities Detected by Wide-Field Fluorescein Angiography in Eyes with Branch Retinal Vein Occlusion

et al. 2018

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Purpose: To evaluate the location of microvascular abnormalities using wide-field fluorescein angiography (WFFA) and investigate the impact on visual outcome in eyes with branch retinal vein occlusion (BRVO). Methods: Forty eyes of 39 patients (24 males and 15 females with an average age of 71 years) were retrospectively reviewed. One patient had BRVO bilaterally. WFFA was performed in all patients to evaluate perfusion status and detect microvascular abnormalities. The WFFA images were divided into 3 zones: zone 1, posterior pole; zone 2, mid-periphery; zone 3, far periphery, in order to document the presence of microvascular abnormalities. Scatter retinal photocoagulation (PC) was performed for retinal neovascularization (NV) and/or widespread nonperfused areas (NPAs). Results: The incidence of microvascular abnormalities in zone 3 was significantly (p < 0.0001) less than in zones 1 and 2. The presence of larger NPAs in zone 1, but not in zone 3, was associated with the incidence of NV and vitreous hemorrhage. The presence of peripheral lesions and the application of PC did not affect the visual outcome. Conclusion: The presence of peripheral abnormalities or scatter PC for NPAs did not affect the visual outcome in eyes with BRVO.

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Section: Introductionmentioning

confidence: 99%

Peripheral Microvascular Abnormalities Detected by Wide-Field Fluorescein Angiography in Eyes with Branch Retinal Vein Occlusion

et al. 2018

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“…We previously reported [5] that binarization of wide-field ICGA images enabled quantification of choroidal vessel density in the eyes with central serous chorioretinopathy. In the current report, the same method was used to evaluate the change before and after the therapy in the eyes with VKH disease.…”

Section: Discussionmentioning

confidence: 99%

“…We previously reported binarization technique of wide-field ICGA images in the eyes with central serous chorioretinopathy [5], leading to a possibility of densitometry of choroidal vessels in wider area. In this current report, the same technique was applied to evaluate a densitometry of choroidal vessels before and after steroid therapy in the eyes with VKH disease.…”

Section: Binarization Of Wide-field Indocyanine Green Angiography Imagesmentioning

confidence: 99%

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Wide-field fluorescein and indocyanine green angiography findings in the eyes with Vogt-Koyanagi-Harada disease

Kurobe

Hirano

Niwa

et al. 2017

J Ophthal Inflamm Infect

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BackgroundThe purpose of this study is to report wide-field angiography findings before and after steroid therapy in a case with bilateral Vogt-Koyanagi-Harada (VKH) disease.ResultsA 44-year-old woman presented with bilateral blurred vision and metamorphopsia accompanied by symptoms of headache and tinnitus. The baseline best-corrected visual acuity was 20/20 in both eyes. Ophthalmic examination revealed a shallow anterior chamber and panuveitis accompanied by multiple serous retinal detachments in both eyes and ciliochoroidal detachments in the left eye. Wide-field fluorescein angiograms showed hyperfluorescene indicating pooling corresponding to multiple serous retinal detachments in the posterior lesion and vascular leakage in the peripheral retina and choroid, resolved after steroid tapering therapy. Interestingly, wide-field indocyanine angiograms revealed narrowing of choroidal vessels in the acute phase and its normalization with resolution of inflammation after the therapy.ConclusionsEyes with Vogt-Koyanagi-Harada disease had peripheral chorioretinal vascular leakage and choroidal vessel narrowing in the acute phase. Wide-field angiography is a useful tool to reveal peripheral chorioretinal findings and assess diameters and density of choroidal vessels.

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“…Dilated choroidal vessels detected in UWF ICGA may serve as a predictor for disease progression. A new method for subtracting and binarizing UWF angiographic images and quantifying the choroidal vessel density was recently developed [49]. The choroidal vessel density increased in eyes with CSC compared to control eyes.…”

Section: Central Serous Chorioretinopathymentioning

confidence: 99%

Ultra-Widefield Retina Imaging: Principles of Technology and Clinical Applications

Lee

Sagong

2016

J Retin

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The peripheral retina is frequently affected by various diseases and ultra-widefield (UWF) imaging has become an essential tool for evaluation of peripheral retinal pathology. The wide angle and high resolution of this imaging device were recently updated along with multimodal capabilities, including pseudocolor fundus photographs, fluorescein and indocyanine green angiography, and autofluorescence images. Using this UWF technology, important clinical observations have been made in the normal population and patients with certain diseases including diabetic retinopathy, retinal vascular occlusion, retinal detachment, uveitis, age-related macular degeneration, and choroidal tumors. Although peripheral distortion and the need for clinical validation are obstacles to overcome for the accurate quantification and more generalized use, UWF imaging has provided new insights into a variety of disorders and has become the standard-ofcare imaging modality for many diseases. Therefore, use of UWF retinal imaging for the daily retina practice in the near future is inevitable. This review will describe the principles of UWF technologies with several modalities, and include its clinical applications and then suggest future directions.

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Densitometry of Choroidal Vessels in Eyes With and Without Central Serous Chorioretinopathy by Wide-Field Indocyanine Green Angiography

Cited by 40 publications

References 45 publications

Peripheral Microvascular Abnormalities Detected by Wide-Field Fluorescein Angiography in Eyes with Branch Retinal Vein Occlusion

Peripheral Microvascular Abnormalities Detected by Wide-Field Fluorescein Angiography in Eyes with Branch Retinal Vein Occlusion

Wide-field fluorescein and indocyanine green angiography findings in the eyes with Vogt-Koyanagi-Harada disease

Ultra-Widefield Retina Imaging: Principles of Technology and Clinical Applications

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