Wide-field fluorescein and indocyanine green angiography findings in the eyes with Vogt-Koyanagi-Harada disease

Abstract

BackgroundThe purpose of this study is to report wide-field angiography findings before and after steroid therapy in a case with bilateral Vogt-Koyanagi-Harada (VKH) disease.ResultsA 44-year-old woman presented with bilateral blurred vision and metamorphopsia accompanied by symptoms of headache and tinnitus. The baseline best-corrected visual acuity was 20/20 in both eyes. Ophthalmic examination revealed a shallow anterior chamber and panuveitis accompanied by multiple serous retinal detachments in both eyes and ciliochoroidal detachments in the left eye. Wide-field fluorescein angiograms showed hyperfluorescene indicating pooling corresponding to multiple serous retinal detachments in the posterior lesion and vascular leakage in the peripheral retina and choroid, resolved after steroid tapering therapy. Interestingly, wide-field indocyanine angiograms revealed narrowing of choroidal vessels in the acute phase and its normalization with resolution of inflammation after the therapy.ConclusionsEyes with Vogt-Koyanagi-Harada disease had peripheral chorioretinal vascular leakage and choroidal vessel narrowing in the acute phase. Wide-field angiography is a useful tool to reveal peripheral chorioretinal findings and assess diameters and density of choroidal vessels.

Multimodal Imaging in a Case of Idiopathic Neuroretinitis

“…We speculate that lymphocytes or other inflammatory cells recruited at the optic disc might diffusely infiltrate into the retina and the choroid. WFICGA disclosed multiple hypofluorescent dark spots in the mid-periphery of the left eye, which are usually observed in eyes with diffuse choroiditis such as Vogt-Koyanagi-Harada disease [6]. Taken all together, the current case appeared to have an involvement of optic disc, entire retina, and choroid.…”

Ultra-Widefield Swept-Source Optical Coherence Tomography Findings of Peripheral Retinal Degenerations and Breaks

“…8 The location of retinal peripheral degenerations was determined with UWF fundus photographs, eg, posterior pole was defined as retina within the major temporal vascular arcades and slightly just beyond. [9][10][11][12] Mid-periphery was defined as retina extending from the vascular arcades to the posterior edge of vortex vein ampulla. Far-periphery was https://doi.org/10.2147/OPTH.S350080…”

“…Clinical Ophthalmology 2021:15 4740 defined as anterior edge of vortex vein ampulla and beyond to pars plana as previously reported. [9][10][11][12] SSOCT images of peripheral retinal lesions were acquired with this device (Silverstone) and the SSOCT findings around the peripheral retinal degenerations such as the presence of subretinal fluid (SRF) and presence of vitreoretinal traction were investigated.…”