Densitometric evaluation of bone-prosthetic counterface in hip and knee arthroplasty with modern implants

Lepri, Andrea Cozzi; Giorgini, Marco; Signorini, C; Carulli, Christian; Civinini, Roberto; Brandi, Maria Luisa; Innocenti, Massimo

doi:10.11138/ccmbm/2016.13.2.144

Cited by 6 publications

(4 citation statements)

References 47 publications

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“…Therefore, the integration of the implant prosthesis and the host bone on the interface and the promotion of host bone regeneration have become a momentous indicator for evaluating prostheses performance. The nature of the interaction between the joint prosthesis and host bone interface is actually the process of bone formation and resorption ( Lepri et al, 2016 ). Bone mesenchymal stem cells (BMSCs) play an important role in bone formation.…”

Section: Introductionmentioning

confidence: 99%

Cyclic Mechanical Strain Regulates Osteoblastic Differentiation of Mesenchymal Stem Cells on TiO2 Nanotubes Through GCN5 and Wnt/β-Catenin

Liu

Cheng

Zhao

et al. 2021

Front. Bioeng. Biotechnol.

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Bone marrow mesenchymal stem cells (BMSCs) play a critical role in bone formation and are extremely sensitive to external mechanical stimuli. Mechanical signals can regulate the biological behavior of cells on the surface of titanium-related prostheses and inducing osteogenic differentiation of BMSCs, which provides the integration of host bone and prosthesis benefits. But the mechanism is still unclear. In this study, BMSCs planted on the surface of TiO2 nanotubes were subjected to cyclic mechanical stress, and the related mechanisms were explored. The results of alkaline phosphatase staining, real-time PCR, and Western blot showed that cyclic mechanical stress can regulate the expression level of osteogenic differentiation markers in BMSCs on the surface of TiO2 nanotubes through Wnt/β-catenin. As an important member of the histone acetyltransferase family, GCN5 exerted regulatory effects on receiving mechanical signals. The results of the ChIP assay indicated that GCN5 could activate the Wnt promoter region. Hence, we concluded that the osteogenic differentiation ability of BMSCs on the surface of TiO2 nanotubes was enhanced under the stimulation of cyclic mechanical stress, and GCN5 mediated this process through Wnt/β-catenin.

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Section: Introductionmentioning

confidence: 99%

Cyclic Mechanical Strain Regulates Osteoblastic Differentiation of Mesenchymal Stem Cells on TiO2 Nanotubes Through GCN5 and Wnt/β-Catenin

Liu

Cheng

Zhao

et al. 2021

Front. Bioeng. Biotechnol.

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“…The dual-energy X-ray absorption assay (DEXA) is a well-established method for monitoring patients after THA 11 . DEXA can detect small changes in BMD around a stem 12,13 , therefore, it is considered as the most reliable method of assessing periprosthetic bone stress shielding and proximal femur remodeling after THA 14 .In recent years, various types of cementless short stems have been introduced; however, little is known about bone remodeling and periprosthetic BMD associated with them. Several studies have reported that cementless short stems might reduce periprosthetic bone loss in the proximal femur compared with that associated with traditional THA 15,16 .…”

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confidence: 99%

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confidence: 99%

Rectangular tapered short stem excellently preserves proximal bone mineral density preservation than tapered wedge short stem

ANJIKI,

HAYASHI,

FUJISHIRO

et al. 2023

Acta Orthop Belg

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Fitmore stem is a rectangular, tapered, short, cementless stem. A characteristic feature of this stem is that it provides rotational stability due to the high medullary occupancy achieved by its rectangular cross-section and thick antero- posterior width. We aimed to investigate the differences in periprosthetic bone remodelling between a rectangular- tapered short stem and a short tapered-wedge stem. Eighty patients who underwent primary total hip arthroplasty using a rectangular-tapered short stem (Fitmore) or a short tapered-wedge stem (Tri-Lock BPS) were enrolled in this study. Bone mineral densities (BMDs) in the seven Gruen zones were evaluated using dual-energy X-ray absorptiometry at baseline, and at 6 and 24 months postoperatively. Peri-prosthetic BMD and clinical factors were assessed and compared. In addition, correlations between periprosthetic BMD changes and stem anteversion error were analyzed using Pearson’s correlation coefficient in the two groups. A significantly better postoperative periprosthetic BMD change was found in zones 1 and 7 in the rectangular-tapered group. Additionally, no significant correlation was observed between stem anteversion error and periprosthetic BMD changes in the rectangular-tapered groups. However, in the tapered-wedge group, there were significant negative correlations between the stem anteversion error and BMD changes at 6 months and 24 months in zones 1 and 7. In the rectangular-tapered group, a significantly better postoperative periprosthetic BMD change was found particularly in the region proximal to the stem. Rectangular-tapered short stem can be more resistant to rotation due to higher medullary occupancy and may lead to better periprosthetic BMD than the tapered-wedge short stem, especially in the proximal region of the stem.

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“…The average age was 62.0 ± 7.4 years (range, 47 to 77 years) in the RM group and 61.6 ± 6.9 years (range, 47 to 75 years) in the IT group (p = 0.532). Dual xray absorptiometry (DXA) is a well-validated procedure for measuring BMD with the total hip implant in situ [14][15][16][17][18] . We used the QDR 4500 Elite device (Hologic) for our measurements.…”

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confidence: 99%

An Isoelastic Monoblock Cup Retains More Acetabular and Femoral Bone Than a Modular Press-Fit Cup

Brodt

Jacob

Nowack

et al. 2021

Journal of Bone and Joint Surgery

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Background: For cup revision after total hip arthroplasty, sufficiently good periacetabular bone stock is a prerequisite for fixation of the revision implant. Cementless cups can lead to a relevant reduction of peri-implant bone mineral density (BMD) through stress-shielding.Methods: Fifty patients were included in this prospective randomized controlled trial. Group 1 (RM group) received an isoelastic monoblock cup (RM Pressfit vitamys; Mathys). Group 2 (IT group) received a modular titanium cup (Allofit-S IT Alloclassic with a polyethylene liner; Zimmer). Periacetabular BMD was determined and subdivided into 4 regions of interest by dual x-ray absorptiometry at 1 week (baseline) and at 4 years postoperatively. Our primary outcome was reduction in periacetabular BMD.Results: Periacetabular BMD was reduced by an average of 15.1% in the RM group and 16.5% in the IT group at 4 years postoperatively. No significant difference was found between the 2 groups over the periacetabular structure as a whole. However, the decrease of BMD in the polar region was significantly different in the RM group (4.9% ± 10.0%) compared with the IT group (15.9% ± 14.9%, p = 0.005). Use of the isoelastic RM cup showed significantly less bone loss than the modular IT cup.Conclusions: Relevant loss of BMD at 4 years after surgery was identified in the periacetabular region in both groups. No differences between the 2 cup systems were found when looking at the overall periacetabular region. As a secondary outcome, less postoperative periacetabular bone loss occurred in the polar region when an isoelastic cup was used. Longer follow-up is required to allow for conclusions to be drawn about the long-term course of the 2 cup systems.Level of Evidence: Therapeutic Level I. See Instructions for Authors for a complete description of levels of evidence.Disclosure: Mathys provided a grant to Jena University Hospital for qCT (quantitative computed tomography) software to support a preliminary study. As a result of metal artifacts, DXA was used instead of qCT in this study. On the Disclosure of Potential Conflicts of Interest forms, which are provided with the online version of the article, one or more of the authors checked "yes" to indicate that the author had a relevant financial relationship in the biomedical arena outside the submitted work (http://links.lww.com/JBJS/G360).

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Densitometric evaluation of bone-prosthetic counterface in hip and knee arthroplasty with modern implants

Cited by 6 publications

References 47 publications

Cyclic Mechanical Strain Regulates Osteoblastic Differentiation of Mesenchymal Stem Cells on TiO2 Nanotubes Through GCN5 and Wnt/β-Catenin

Cyclic Mechanical Strain Regulates Osteoblastic Differentiation of Mesenchymal Stem Cells on TiO2 Nanotubes Through GCN5 and Wnt/β-Catenin

Rectangular tapered short stem excellently preserves proximal bone mineral density preservation than tapered wedge short stem

An Isoelastic Monoblock Cup Retains More Acetabular and Femoral Bone Than a Modular Press-Fit Cup

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