Dengue virus detection in <i>Aedes aegypti</i>
 larvae from southeastern Brazil

Cecílio, Samyra Giarola; Júnior, Willer Ferreira Silva; Tótola, Antônio Helvécio; Magalhães, Cíntia Lopes de Brito; Ferreira, Jaqueline Maria Siqueira; Magalhães, José Carlos de

doi:10.1111/jvec.12134

Cited by 20 publications

(11 citation statements)

References 33 publications

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“…Transovarial transmission of dengue virus was documented in the field, where different serotypes of dengue virus in larvae or male adult mosquitoes were detected in different areas of the world. 14, 15, 16 A series of laboratory studies confirmed that Ae. aegypti and Ae.…”

Section: Introductionmentioning

confidence: 87%

Vector competence and transovarial transmission of two Aedes aegypti strains to Zika virus

Guo

Deng

et al. 2017

Emerging Microbes & Infections

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Zika virus (ZIKV) has become a serious threat to global health since the outbreak in Brazil in 2015. Additional Chinese cases have continuously been reported since the first case of laboratory-confirmed ZIKV infection in China on 6 February 2016. Aedes aegypti is the most important vector for ZIKV. This study shows that two strains from China exhibit high levels of midgut infection and highly disseminated infection of salivary glands and ovaries. Both strains can transmit ZIKV to infant mice bitten by infectious mosquitoes. Moreover, the results provide the evidence of transovarial transmission of ZIKV in mosquitoes. The study indicates that the two Ae. aegypti strains are not only effective transmission vectors but also persistent survival hosts for ZIKV during unfavorable inter-epidemic periods. This function as a reservoir of infection has epidemiological implications that further enhance the risk of potential future outbreaks.

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Section: Introductionmentioning

confidence: 87%

Vector competence and transovarial transmission of two Aedes aegypti strains to Zika virus

Guo

Deng

et al. 2017

Emerging Microbes & Infections

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“…Six studies reported exclusively on dengue infection rates in wild mosquito populations (Table 2). Cecílio et al [175] observed four positive pools, out of 54 tested, among Aedes mosquitoes collected in two regions of Brazil over the course of 17 months, through the installation of ovitraps in public schools. Cruz et al [155] detected eight positive pools, out of 50 Ae.…”

Section: Resultsmentioning

confidence: 99%

“…Few studies examined natural infection rates of Zika virus [129,130], vertical transmission [179], or co-infection with other viruses [126]. This is in contrast to the wealth of research available on natural infection and co-infection for dengue and chikungunya viruses, although vertical transmission research was sparse for all three viruses [144,148,156,175,178,197,198]. Based on the internationally recognized urgency of Zika virus infection as a public health concern, and potential increase in the importance of this and other emerging arboviruses in the future, further research on arbovirus vectors and transmission dynamics is of pressing need.…”

Section: Discussionmentioning

confidence: 99%

Arbovirus Vectors of Epidemiological Concern in the Americas: A Scoping Review of Entomological Studies on Zika, Dengue and Chikungunya Virus Vectors

Jones

Kulkarni

Davidson

et al. 2019

Preprint

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27 Background 28 Three arthorpod-borne viruses (arboviruses) causing human disease have been the focus 29 of a large number of studies in the Americas since 2013 due to their global spread and 30 epidemiological impacts: Zika, dengue, and chikungunya viruses. A large proportion of 31 infections by these viruses are asymptomatic. However, all three viruses are associated with 32 moderate to severe health consequences in a small proportion of cases. Two mosquito species, 33 Aedes aegypti and Aedes albopictus, are among the world's most prominent arboviral vectors, 34 and are known primary vectors for all three viruses in the Americas. 35 Objectives 2 36 This review summarizes the state of the entomological literature surrounding the biology 37 and ecology of vectors of Zika, dengue and chikungunya viruses and factors affecting virus 38 transmission. The rationale of the review was to elucidate consensus and discord between 39 studies, and guide future research based on identified knowledge gaps. 40 Results 41 A total of 196 studies were included in the scoping review after initial screening and 42 subsequent exclusion of out-of-scope studies, secondary data publications, duplicate records, and 43 studies unavailable in English language. 44 Key findings 45 Temperature and humidity have the strongest impact on mosquito distribution and 46 dynamics, development of immatures and arborviral infection rates. Low socioeconomic status 47 and related factors, including poor infrastructure, inconsistent access to water, and high 48 household resident density, have been consistently associated with arbovirus vector occurrence. 49 Effects of interspecific competition on arboviral vector species is currently poorly understood. 50 Vector competence for Zika virus is well established for Ae. aegypti and Ae. albopictus. 51 Information on Zika virus vector transmission dynamics is sparse in contrast to the wealth of 52 research available for dengue and chikungunya viruses. 53 Conclusions 54Based on the internationally recognized urgency of Zika virus infection as a public health 55 concern, further research on arbovirus vectors and transmission dynamics is of pressing need. 56 57

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“…Natural vertical transmission of DENV in Ae. aegypti has been demonstrated in the states of Minas Gerais 35,[37][38][39] , Pernambuco 40 , Ceará 36 , Mato Grosso [40][41][42] Rio de Janeiro 43 and Amazonas 44 .…”

Section: Discussionmentioning

confidence: 99%

Silent circulation of dengue virus in Aedes albopictus (Diptera: Culicidae) resulting from natural vertical transmission

Ferreira-de-Lima

Andrade

Thomazelli

et al. 2020

Sci Rep

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Vertical transmission in Aedes aegypti and Aedes albopictus is considered a maintenance mechanism for dengue virus (DENV) during unfavorable conditions and may be implicated in dengue outbreaks. Since DENV infection dynamics vary among wild-type viruses and vector populations, vertical transmission rates can also vary between regions. However, even though São Paulo is the most populous city in the Americas and has experienced major dengue epidemics, natural vertical transmission had never been detected in this area before. Here we confirm and describe for the first time natural vertical transmission of DENV-3 in two pools of male Ae. albopictus from the city of São Paulo. The detection of DENV-3 in years when no human autochthonous cases of this serotype were recorded suggests that silent circulation of DENV-3 is occurring and indicates that green areas may be maintaining serotypes that are not circulating in the human population, possibly by a vertical transmission mechanism.

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Dengue virus detection in Aedes aegypti larvae from southeastern Brazil

Cited by 20 publications

References 33 publications

Vector competence and transovarial transmission of two Aedes aegypti strains to Zika virus

Vector competence and transovarial transmission of two Aedes aegypti strains to Zika virus

Arbovirus Vectors of Epidemiological Concern in the Americas: A Scoping Review of Entomological Studies on Zika, Dengue and Chikungunya Virus Vectors

Silent circulation of dengue virus in Aedes albopictus (Diptera: Culicidae) resulting from natural vertical transmission

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