Dengue Virus 3 Genotype 1 Associated with Dengue Fever and Dengue Hemorrhagic Fever, Brazil

Abstract

Dengue serotype 3 viruses were isolated from patients in Brazil from 2002 through 2004. On the basis of phylogenetic analyses, these isolates were assigned genotype 1. This genotype had never been reported in South America before. Its appearance indicates a major risk factor for dengue epidemics and severe disease.

Infection of the central nervous system with dengue virus 3 genotype I causing neurological manifestations in Brazil

“…Our report describes a DENV infection in the CNS caused by DENV-3 genotype I, which has also been detected in human cases and mosquitos (Figure 1) (6) (7) (8) . As DENV-3 genotype I was detected in different years in the same city (Belo Horizonte: 2002, 2003,and 2004, this genotype has been circulating in this region since that time (6) .…”

“…As DENV-3 genotype I was detected in different years in the same city (Belo Horizonte: 2002, 2003,and 2004, this genotype has been circulating in this region since that time (6) . Our previous studies demonstrated that DENV-3 genotype I had neurovirulent potential in a murine model (8) .…”

“…Our laboratory has isolated and characterized DENV-3 genotype I from patients and mosquitoes in different cities of Minas Gerais (Figure 1), most recently (2013) in Contagem, MG (unpublished data) (6) (7) . The patients presented with a wide range of clinical manifestations including headache, light sensitivity, retro-orbital pain, general body pain (arthralgia, myalgia), vomiting, and hemorrhage (6) .…”

“…Our laboratory has isolated and characterized DENV-3 genotype I from patients and mosquitoes in different cities of Minas Gerais (Figure 1), most recently (2013) in Contagem, MG (unpublished data) (6) (7) . The patients presented with a wide range of clinical manifestations including headache, light sensitivity, retro-orbital pain, general body pain (arthralgia, myalgia), vomiting, and hemorrhage (6) . In addition, previous studies have demonstrated an important feature of DENV-3 genotype I, which is its ability to cause CNS infection and modulate the immunological system in a mouse model that was intracranially inoculated (8) (9) .Neurological manifestations of dengue infection in humans range from a common headache to more severe symptoms, such as nuchal rigidity, reduced consciousness, and convulsions.…”

Serious disease outbreaks caused by viruses transmitted by Aedes aegypti in Brazil

“…DENV-1 has been the predominant serotype in 2016 outbreak. As a consequence of the endemic nature of this disease, this virus has caused severe forms of disease among children, leading to a large number of deaths (2) .…”