Dengue Virus 1 Outbreak in Buenos Aires, Argentina, 2016

Tittarelli, Estefanía; Lusso, Silvina; Goya, Stephanie; Rojo, Gabriel Lihue; Natale, Mónica; Viegas, Mariana; Mistchenko, Alicia; Valinotto, Laura

doi:10.3201/eid2310.161718

Cited by 9 publications

(4 citation statements)

References 7 publications

(6 reference statements)

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“…Analyzing all 240 sequences of Clade I, only those two sequences and one from Argentina 2016 had this amino acid. During a study conducted in Argentina from December 2015 to April 2016, this amino acid was not reported 18 . In fact, in all the dataset analyzed here, the only sequences that present this shared amino acid are two of our study detected in 2014 and 2015 and the one from Argentina, detected afterwards in that country.…”

Section: Discussionmentioning

confidence: 98%

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DENV-1 Genotype V in Brazil: Spatiotemporal dispersion pattern reveals continuous co-circulation of distinct lineages until 2016

Bruycker-Nogueira

Souza

Chouin-Carneiro

et al. 2018

Sci Rep

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In Brazil, DENV-1 introduced in the 80’s, remained the prevalent serotype from 2012 to 2016. After its re-emergence in the country in 2009, the co-circulation of different viral lineages was identified, however, its transmission dynamics afterwards, was not fully characterized. In this study, we performed the continuous molecular surveillance after the reemergence period (2012 to 2016), covering the 30 years of circulation of DENV-1 in Brazil. Phylogenetic analysis allowed confirmation of the continued presence of genotype V, as well as three distinct co-circulating lineages. The molecular characterization of the E gene presented two new amino acid substitutions previously unidentified in the country. Phylogeographic analysis has shown that a large flow of migrations has occurred between Brazil and Argentina in the last 10 years.

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Section: Discussionmentioning

confidence: 98%

“…However, we observed a more recent movement of this clade to the Northeast region of Brazil and to Argentina. Tittarelli and collaborators studying isolates from Argentina during the epidemic that occurred in early 2016 highlights that a sample of their study was related to samples from the North region of Brazil 18 .…”

Section: Discussionmentioning

confidence: 99%

DENV-1 Genotype V in Brazil: Spatiotemporal dispersion pattern reveals continuous co-circulation of distinct lineages until 2016

Bruycker-Nogueira

Souza

Chouin-Carneiro

et al. 2018

Sci Rep

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“…Furthermore, outbreaks from all four DENV serotypes have been recorded in Argentina in recent years and immunological status could at times have an enhancing or suppressing role in the incidence of apparent DENV disease. 43 Last, the rate at which mosquito populations evolve or are displaced in particular regions has not been assessed and could have a large influence on transmission risk. Ultimately, accurate assessment of arbovirus risk will require nuanced models which fully consider the complexity of interactions between virus, temperature, mosquito genetics, and host.…”

Section: Discussionmentioning

confidence: 99%

Differential Effects of Temperature and Mosquito Genetics Determine Transmissibility of Arboviruses by Aedes aegypti in Argentina

Ciota

Chin

Ehrbar

et al. 2018

The American Journal of Tropical Medicine and Hygiene

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(L.) (Diptera: Culicidae) have a global distribution and are the primary vector of a number of mosquito-borne viruses responsible for epidemics throughout the Americas. As in much of South America, the threat from pathogens including dengue virus (DENV; Flaviviridae, ) and chikungunya virus (CHIKV; Togaviridae,) has increased in Argentina in recent years. The complexity of transmission cycles makes predicting the occurrence and intensity of arbovirus outbreaks difficult. To gain a better understanding of the risk of DENV and CHIKV in Argentina and the factors influencing this risk, we evaluated the role of population and temperature in the vector competence and vectorial capacity (VC) of from geographically and ecologically distinct locations. Our results demonstrate that intrinsic and extrinsic factors including mosquito population, viral species, and temperature significantly influence both vector competence and overall VC of in Argentina, yet also that the magnitude of these influences is highly variable. Specifically, results suggest that CHIKV competence is more dependent on mosquito genetics than is DENV competence, whereas temperature has a greater effect on DENV transmission. In addition, although there is an overall positive correlation between temperature and competence for both viruses, there are exceptions to this for individual virus-population combinations. Together, these data establish large variability in VC for these pathogens among distinct populations in Argentina and demonstrate that accurate assessment of arbovirus risk will require nuanced models that fully consider the complexity of interactions between virus, temperature, mosquito genetics, and hosts.

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“…Albopictus from flavi virus family are the vectors of this RNA Virus (DEN), however Aedes Aegypti causing Dengue fever is more prevalent in our Urban Areas, species of fla-vi virus Ae albopictus is also being detected in Khyber Pakhtunkhwa and Punjab during Dengue outbreak season. [2][3][4] In last decade the dengue graph has ascended greatly & of total population more than 40% are at risk. 5 Dengue children shows many typical changes ranging from self limiting fever having arthralgia, myalgia, headache, rash, vomiting and diarrhea with atypical changes involving hepatic system (causing protein imbalance leading to increased plasma leakage) to Central Nervous System changes leading to hemorrhagic complications like dengue hemorrhagic fever (DHF) markedly seen with derangement of all blood cells & clotting profile (severity of disease is directly proportional to damage done to these systems).…”

Section: Introductionmentioning

confidence: 99%

Dengue Fever

Zeb¹,

Ahmed²,

Zeb³

2018

TPMJ

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Objectives: To note ultrasound findings in patient of Dengue Fever in pediatricage group and to find relation between ultrasonographic findings and severity of diseasein terms decrease in platelets. Study Design: Cross sectional descriptive study. Setting:Department of Pediatric Khyber Teaching Hospital, Peshawar. Period: August 2017 to Dec 2017.Methodology: Data was collected randomly from 183 patients using pre designed questionnaireby interviewers for biodata, ultrasonography for radiological findings and analyzed by SPSS21.0. Mean ± standard deviation was calculated for numerical variables like age where as forcategorical variables frequency and percentage was calculated. Results: In the study 56.3%were males while 43.7% were recorded as females with mean age of 6.53 ± 3.40 Years. 18.6%showing anti-dengue serology (IgG & IgM) positive while 94.5% subjects showed positive NS-1,in other investigations 87% had thrombocytopenia in different categories with mild > moderate> severe. In the ultrasongraphic findings hepatomegaly and spleenomegaly shared maximumnumbers of 28.4% while Ascites 23.5%, Pleural Effusion 7.1% & Gall Bladder thickness 7.1%.A P-Value of ≤0.05 was found when all these ultrasonographic findings were correlated withseverity of disease in terms of decrease in numbers of platelets. Conclusion: DEN Virus iscommon most disease in our part of world. This study shows maximum number of patients withNS-1 shows hepatomegaly and spleenomegaly in ultrasonographic changes and the positiverelation has been shown between decrease in platelets count with ultrasonographic findings.

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Dengue Virus 1 Outbreak in Buenos Aires, Argentina, 2016

Cited by 9 publications

References 7 publications

DENV-1 Genotype V in Brazil: Spatiotemporal dispersion pattern reveals continuous co-circulation of distinct lineages until 2016

DENV-1 Genotype V in Brazil: Spatiotemporal dispersion pattern reveals continuous co-circulation of distinct lineages until 2016

Differential Effects of Temperature and Mosquito Genetics Determine Transmissibility of Arboviruses by Aedes aegypti in Argentina

Dengue Fever

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