DENV-1 Genotype V in Brazil: Spatiotemporal dispersion pattern reveals continuous co-circulation of distinct lineages until 2016

Bruycker-Nogueira, Fernanda de; Souza, Thiara Manuele Alves de; Chouin-Carneiro, Thaís; Faria, Nieli Rodrigues da Costa; Santos, Jaqueline Bastos; Torres, María Celeste; Ramalho, Izabel Letícia Cavalcante; Aguiar, Shirlei Ferreira; Nogueira, Rita Maria Ribeiro; Filippis, Ana María Bispo de; Santos, Flávia Barreto dos

doi:10.1038/s41598-018-35622-x

Cited by 17 publications

(30 citation statements)

References 25 publications

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“…another clade of DENV-1 in Brazil, closely related to strains from Caribbean countries. It corroborates a most recent study on the phylogenetic evaluation of DENV-1 in the country [44], which suggests at least three clades of this virus in the Brazilian territory.…”

Section: Plos Onesupporting

confidence: 90%

“…The DENV-1 genotype V found in the infected A. albopictus was also detected in previous Brazilian studies [42][43][44]. The strain from the study setting is closely related to viruses that have circulated previously in large urban centers of three different regions in Brazil (Southeast, Northeast, and Midwest), showing the capacity of the virus dispersion from urban to rural areas.…”

Section: Discussionsupporting

confidence: 78%

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First report of Aedes albopictus infected by Dengue and Zika virus in a rural outbreak in Brazil

et al. 2020

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In Brazil, Dengue (DENV) and Zika (ZIKV) viruses are reported as being transmitted exclusively by Aedes aegypti in urban settings. This study established the vectors and viruses involved in an arbovirus outbreak that occurred in 2019 in a rural area of Espírito Santo state, Brazil. Mosquitoes collected were morphologically identified, sorted in samples, and submitted to molecular analysis for arboviruses detection. Phylogenetic reconstruction was performed for the viral sequence obtained. All 393 mosquitoes were identified as Aedes albopictus. DENV-1 genotype V was present in one sample and another sample was positive for ZIKV. The DENV-1 clustered with viruses that have circulated in previous years in large urban centers of different regions in Brazil. This is the first report of A. albopictus infected by DENV and ZIKV during an outbreak in a rural area in Brazil, indicating its involvement in arboviral transmission. The DENV-1 strain found in the A. albopictus was not new in Brazil, being involved previously in epidemics related to A. aegypti, suggesting the potential to A. albopictus in transmitting viruses already circulating in the Brazilian population. This finding also indicates the possibility of these viruses to disperse across urban and rural settings, imposing additional challenges for the control of the diseases.

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Section: Plos Onesupporting

confidence: 90%

Section: Discussionsupporting

confidence: 78%

First report of Aedes albopictus infected by Dengue and Zika virus in a rural outbreak in Brazil

et al. 2020

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“…Our phylogenetic analysis supports that DENV-1 genotype V has been widely distributed in northern Brazil, and that other South American countries have contributed to its introduction into this country. The 12 new DENV-1 sequences were classified as genotype V, and grouped into lineage BR4 (previously called Clade Ib by Nogueira 2018 [ 32 ]). This result was expected, since this genotype has been the most prevalent in the Americas over the last 40 years [ 9 ].…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, our results summarize several aspects about BR4 lineage phylodynamics and its spread pattern in Brazil. Briefly, BR4 was introduced in Brazil through its northern region, coming from Venezuela around 2007 [ 32 ]. After its introduction, this lineage disseminated to several states in the northern region, including Amapá, in addition to other regions of Brazil, such as the Southeast, Midwest, and Northeast.…”

Section: Discussionmentioning

confidence: 99%

Adaptive Evolution of New Variants of Dengue Virus Serotype 1 Genotype V Circulating in the Brazilian Amazon

Ribeiro

Gill

Ribeiro

et al. 2021

Viruses

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Dengue virus (DENV) is a mosquito-borne viral pathogen that plagues many tropical-climate nations around the world, including Brazil. Molecular epidemiology is a growing and increasingly invaluable tool for understanding the dispersal, persistence, and diversity of this impactful virus. In this study, plasma samples (n = 824) from individuals with symptoms consistent with an arboviral febrile illness were analyzed to identity the molecular epidemiological dynamics of DENV circulating in the Brazilian state of Amapá. Twelve DENV type 1 (DENV-1) genomes were identified, which were phylogenetically related to the BR4 lineage of genotype V. Phylodynamics analysis suggested that DENV-1 BR-4 was introduced into Amapá around early 2010, possibly from other states in northern Brazil. We also found unique amino acids substitutions in the DENV-1 envelope and NS5 protein sequences in the Amapá isolates. Characterization of the DENV-1 BR-4 sequences highlights the potential of this new lineage to drive outbreaks of dengue in the Amazon region.

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“…Brazil is one of the countries with the largest number of DF cases and an annual incidence rate higher than 100/100,000 inhabitants 4 . Since 2010, the four dengue serotypes circulate in all Brazilian regions, being DENV1 the most prevalent over the last five years 5 . In 2015, Brazil faced the largest dengue epidemics of the last decade, with a total of 1,700,324 reported cases, but only 0.4% were confirmed by laboratory tests 6 .…”

Section: Introductionmentioning

confidence: 99%

Epidemiological and genetic aspects of the largest dengue outbreak recorded in 2015 in Southeastern Brazil

Cabral

Oliveira

Molina

et al. 2021

Rev. Inst. Med. trop. S. Paulo

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Dengue virus, the etiological agent of dengue fever (DF) occurs in four genetically distinct serotypes (DENV1-4), being transmitted by female Aedes mosquitoes. DF incidence is increasing in Brazil, following vector dispersal, proliferation and DENV serotypes introduction, co-circulation and substitution. Medium- and small-sized cities in Sao Paulo State, such as Marilia (Midwest region), have been affected by huge epidemics. To understand the evolution of DENV epidemics in medium-sized cities, in this study a historical data on DENV incidence (2000-2015) in Marilia, was evaluated. Previous studies disclosed regional and specific DF outcomes associated with 2007 outbreak in that city, when co-circulating DENV1 and DENV3 presented different hematological profiles. In this study, characteristics of 2007 DENV epidemics were compared to the epidemiological, hematological and demographic outlines of the major outbreak of DENV1 in Marilia in 2015. DENV1 genetic diversity was assessed through capsid and pre-membrane junction encoding gene (CprM) sequencing. The results revealed circulation of DENV1 serotype from 2007 to 2015, with epidemics occurring every three-years until 2013 and then, increasing yearly. There were significant differences in hematological profiles of DENV1 patients between 2015 and 2007. CprM showed DENV1 genetic variability in 2015, contrasting with the unique sequence pattern in 2007. These results reinforce the regional and temporal characteristics of DENV epidemics that need local public health research to improve care for people and to limit the spread of new serotypes/genotypes to uninfected areas.

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DENV-1 Genotype V in Brazil: Spatiotemporal dispersion pattern reveals continuous co-circulation of distinct lineages until 2016

Cited by 17 publications

References 25 publications

First report of Aedes albopictus infected by Dengue and Zika virus in a rural outbreak in Brazil

First report of Aedes albopictus infected by Dengue and Zika virus in a rural outbreak in Brazil

Adaptive Evolution of New Variants of Dengue Virus Serotype 1 Genotype V Circulating in the Brazilian Amazon

Epidemiological and genetic aspects of the largest dengue outbreak recorded in 2015 in Southeastern Brazil

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