Dengue Symptoms Significance in Anti-Dengue Drug Development: Road Less Travelled

Abstract

Dengue outbreak has affected rural areas of Delhi-NCR, Haryana widely but it lacks in surveillance. High cases of dengue symptoms were reported in these regions whereas dengue symptoms have been a neglected issue in the anti-dengue drug development. Therefore, this study aims to analyze the status of the dengue infection, a rural issue of Delhi-NCR, Haryana and to identify the significance of dengue symptoms in anti-dengue drug development. The study was conducted when there is high chance of dengue infection i.e. from August 2015 to October 2015 at OPD Unit of PR Institute of Medical Science & Research, Delhi-NCR, Sonepat. It includes 158 patients from 24 rural areas of Haryana comprising both males and females from different age groups. Out of 20% cases, 6% were IgG-Positive, 9% were IgMPositive and 88% were NS1-Positive and rest 80% was normal. It includes 44% cases of thrombocytopenia. Badkhalsa village (28%), age group 18-24 (34%) and males (63%) reported cases of high infection. It was found that people with fewer platelet counts (Rai village) were not suffering from dengue whereas people with more platelet count reported dengue infection (Badkhalsa village). Interpretation & Conclusion: This study focuses on new research directions by highlighting the dengue symptoms importance in anti-dengue drug development also it is a first attempt to investigate the status of dengue, a rural issue of Delhi-NCR, Haryana and suggests that health authorities and people living in these regions should take initiatives for better health.

Intussusception in an infant complicating dengue infection

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Dengue: The break-bone fever outbreak in Kerala, India

“…petechiae, bleeding gums, epistaxis, menorrhagia, hematuria. Later, bleeding from gastrointestinal tract and sites of trauma, thrombocytopenia, pleural effusion, abdominal pain, restlessness, vomiting and a sudden reduction in temperature, adynamia and fainting can occur [ 7 , 21 ]. Leukopenia, thrombocytopenia, elevation of serum aminotransferase level are seen.…”

“…Detection of IgM, IgG antibodies, NS1 ELISA or duplex Real time polymerase chain reaction during the acute phase are used as diagnostic tests. Virus can be isolated from the blood by mosquito inoculation or mosquito cell culture [ 21 , 22 , 23 ].…”

Molecular & serological study of dengue virus-infected patients attending a tertiary hospital of Dhaka city, Bangladesh (2013 to 2016)

“…Dengue NS1 antigenemia is detectable within 24 h and may persist for nine days following the onset of illness. Simultaneous testing for dengue NS1 along with anti-dengue IgM/IgG provides the diagnostic potential for both early and late dengue disease3. These serological and molecular markers are used not only to confirm the diagnosis but also to categorize the disease severity or increase in risk of progression to more severe forms of dengue infection.…”