Dengue outbreak 2019: clinical and laboratory profiles of dengue virus infection in Dhaka city

Abstract

Background Dengue fever has been one of the most common mosquito-transmitted diseases in the world, affecting more than 128 countries in both tropical and subtropical regions. Bangladesh has been sufferring from dengue outbreaks almost annually since 2000, and in 2019, Bangladesh faced the worst outbreak of dengue to date. This study aimed to provide clinical and biochemical profiles of Bangladesh's dengue-infected patients. Methods This cross-sectional study was conducted from August through December 2019 in three tertiary private hospitals in Dhaka, Bangladesh. We collected information on demographic data, clinical characteristics, and laboratory profiles for 542 confirmed hospitalized acute dengue cases using a structured questionnaire. Results The average age of the enrolled patients was 26.15 years, and about 50% of patients belonged to the age group of 20–40 years. The most frequent among the prevalent clinical symptoms were fever (93.1%), abdominal pain (29.5%), skin rash (25.3%), and diarrhea (19.7%). 316 patients had some complications, such as breathing problems (41.4%), pleural effusion (38.9%), gum bleeding (11.1%), etc. More than 90% of the patients showed seropositivity for the DENV-NS1 antigen. Conclusions Over the last couple of years, dengue fever has become a major health issue for Bangladesh. To reduce the burden of this disease, timely diagnosis and prompt treatment are necessary. This analysis thus yields the clinical features, laboratory profiles, and seropositivity test results of dengue patients from Bangladesh. The research results may help clinicians understand the circumstantial diagnosis of dengue patients and facilitate early intervention.

A community based case-control study to determine the risk factors of dengue fever in Bangladesh

“…The study investigated the risk and protective factors associated with the dengue virus infection in Chattogram, Bangladesh. In view of the study findings, dengue virus infection was higher among the younger people (16-45 years) living in urban and semi-urban areas which was supported by previous studies (El-Gilany et al 2010;R et al 2021). Higher incidence among the young people could be due to their over activities and less concern to health and diseases.…”

Changes in severity of clinical pattern of dengue infection and its management: a cross-sectional study a tertiary care hospital

“…Whereas, in the present study more than half of the study population had Hypotension (64, 60.4%). 15 Thus, the prompt development of shock was not detected in the previous year in comparison with the present study might denote the shelving in the aggressiveness of the disease. 21 DSS is the most severe syndrome that can be fatal.…”

“…14 Different studies found that there is a higher incidence of dengue fever in males in comparison with the female gender. 15 In the present study, 100% of the study population had fever, 32% of patients experienced headaches, and 16% of patients had rashes. There was a study conducted at the dengue corner of Sheikh Hasina burn and plastic surgery institute, in Dhaka medical college, hospital, revealed that 100% of people had a fever and 1.6% of patients had rashes.…”

“…There was a study conducted at the dengue corner of Sheikh Hasina burn and plastic surgery institute, in Dhaka medical college, hospital, revealed that 100% of people had a fever and 1.6% of patients had rashes. 15 WHO classification of dengue diseases is often not feasible in many countries because of a lack of trained health professionals, and adequate laboratories. Facilities to detect DHF by using hematocrit and plasma leakage sign signs are not available in many underdeveloped countries.…”

Massive Third-Wave COVID-19 Outbreak in Bangladesh: A Co-Epidemic of Dengue Might Worsen the Situation

“…An analysis of approximately 40,000 dengue cases over a 17-year period, from 2000 to 2017, indicated that about 50% of all dengue cases are reported during the monsoon season (May–August), whereas the remaining 50% cases are reported during the post-monsoon season (September–December) in Bangladesh [ 17 ]. In Bangladesh, annual outbreaks of dengue have been very common since 2000, and in 2019 the country faced the worst outbreak of dengue to date [ 18 ]. During 2019 the country reported 101,354 dengue cases associated with 179 deaths, according to information from the IEDCR and DGSH of Bangladesh [ 19 ].…”