Dengue fever treatment with Carica papaya leaves extracts

Ahmad, Nisar; Fazal, Hina; Ayaz, Muhammad; Abbasi, Bilal Haider; Mohammad, Ijaz; Fazal, L.

doi:10.1016/s2221-1691(11)60055-5

Cited by 204 publications

(145 citation statements)

References 11 publications

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“…However, C. papaya L. leaf crushed in water increased the red blood cells count (RBC), white blood cell, platelets, and other immune cells during chronic dengue viral infection (Ahmad et al 2011). If the present findings are correlated with this previous case report, Carica papaya L. leaf, containing anti-oxidant and immunostumulating phytochemicals, has a key role in the stimulation of immune cells to reduce dengue viral symptoms.…”

Section: Discussionsupporting

confidence: 83%

In vitrostudy on cytotoxic effect and anti-DENV2 activity ofCarica papayaL. leaf

Joseph¹,

Sankarganesh²,

Ichiyama

et al. 2014

Frontiers in Life Science

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Dengue fever is the most deleterious and rapidly spreading mosquito-borne viral disease, and to date it has resisted attempts to eradicate it. Carica papaya L. leaf extract is traditionally used to cure dengue fever and its associated symptoms. However, no in vitro studies have been reported for the anti-dengue efficacy of this extract. So, the present study attempted to determine the phytochemicals present in Carica papaya L. leaf extracts, as well as their cytotoxic effect and anti-DENV2 activity on the LLC-MK2 cell line. Methanolic extracts, containing triterpenoids and flavonoids, showed cytotoxic effects (CC 50 = 0.6156 mg ml −1 ), whereas a chloroform extract, rich in alkaloids, tannin and saponin, was non-cytotoxic (CC 50 = > 1 mg ml −1 ) to LLC-MK2 cells and it showed inhibitory activity (EC 50 = > 1 mg ml −1 ) against DENV2 with a selectivity index value of ± > 1. This indicates that the crude chloroform extract has moderate or less inhibitory action against DENV2 growth in in vitro conditions. The current study will help in the future development of new and novel drugs against dengue pathogens with high efficacy.

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Section: Discussionsupporting

confidence: 83%

In vitrostudy on cytotoxic effect and anti-DENV2 activity ofCarica papayaL. leaf

Joseph¹,

Sankarganesh²,

Ichiyama

et al. 2014

Frontiers in Life Science

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show abstract

“…However, in previous animal studies [21,22] , C. papaya leaf extracts were prepared using dried leaves processed using various methods. Phytochemical analyses have indicated that C. papaya leaf extract contains chemical compounds such as alkaloids, tannins, antraquinone, cardenolides, steroids, saponins, phenolics, reducing sugars, flavonoids and cardiac glycosides [23][24][25] . These compounds can affect various biological processes in the body in ways that might have harmful or beneficial effects.…”

Section: Discussionmentioning

confidence: 99%

“…The findings of the present study strongly suggest that there could be some active compounds in C. papaya leaves that can enhance haemopoiesis and thrombopoiesis in animals. Recently in Pakistan, a dengue patient was treated with aqueous extract of C. papaya leaves (25 mL, twice daily for 5-consecutive day) and exhibited a rise in platelet count [25] . Chemical analysis of C. papaya leaves showed the presence of considerable amounts of carpaine, malic acid, quinic acid, manghaslin and clitorin, minor quantities of various malic acid derivatives, nicotiflorin, rutin and unidentified constituents [26] .…”

Section: Discussionmentioning

confidence: 99%

Does Carica papaya leaf-extract increase the platelet count? An experimental study in a murine model

Dharmarathna

Wickramasinghe

Waduge

et al. 2013

Asian Pacific Journal of Tropical Biomedicine

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“…The patient received 25 mL of papaya leaf extract twice a day for 5 days. A steady increase in the platelet and white blood cell count was observed after 2 days of treatment [19]. A 23-year-old man was administered a calculated dose for five days.…”

Section: Reported Studies In Humansmentioning

confidence: 99%

Carica Papaya; A Paired and Alternative Therapy of Dengue Fever

Nesar

Omer

Rizvi

et al. 2018

JBT

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The purpose f the study is to explore the prospective use of Carica papaya leaves extracts for Dengue fever that is a painful, debilitating mosquito-borne disease caused by dengue viruses. An estimated 390 million dengue infections occur worldwide each year, with about 96 million resulting in illness. It has been found at height in developing nations like India, Pakistan, Sri Lanka and Bangladesh. Mostly tropical areas have been reported infected. The disease is transmitted by an Aedes mosquito infected with a dengue virus; interestingly it is not transferred from person to person. Symptoms are mild to serious including hemorrhagic fever; a rare complication characterized by high fever, damage to lymph and blood vessels, bleeding from the nose and gums, enlargement of the liver, and failure of the circulatory system and it can cause the death. All the symptoms of disease are due to low platelets count that may become very low if not managed. Consequently, the research reveals that juice of the leaves of the Carica papaya plant from the family Caricaceae help to increase the platelet levels. The present review is done to enlighten the theory of the management of dengue through this alternative therapy that can be implement along with conventional treatment. The covered researches in present study would raise and support the possibility of being, the remedy and significant alternative in the prospect.

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Dengue fever treatment with Carica papaya leaves extracts

Cited by 204 publications

References 11 publications

In vitrostudy on cytotoxic effect and anti-DENV2 activity ofCarica papayaL. leaf

In vitrostudy on cytotoxic effect and anti-DENV2 activity ofCarica papayaL. leaf

Does Carica papaya leaf-extract increase the platelet count? An experimental study in a murine model

Carica Papaya; A Paired and Alternative Therapy of Dengue Fever

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