Dengue Epidemiology: Virus Epidemiology, Ecology, And Emergence

Thomas, Stephen J.; Strickman, Daniel; Vaughn, David W.

doi:10.1016/s0065-3527(03)61006-7

Cited by 92 publications

(64 citation statements)

References 215 publications

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“…Dengue virus (DENV) has four serotypes (DEN [1][2][3][4]. Currently, all the serotypes have difused in tropical and subtropical regions of the world [2].…”

Section: Dengue Virusmentioning

confidence: 99%

Assessment of Dengue Fever Severity Through Liver Function Test

Zubair¹,

Qureshi²,

Jafri³

2017

Dengue - Immunopathology and Control Strategies

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Objective: To assess the utility of liver function tests (LFTs) for early recognition and prediction of severity of dengue fever in hospitalized patients. Study Design: An analytical study. Place and duration of study: Services Institute of Medical Science and Fatima Memorial Hospital, Lahore, from September to December 2010. Methodology: Admited cases of dengue fever were divided into three groups: mild, moderate, and severe increases in aminotransferases. Elevation in LFTs was co-related with good or bad outcome i.e. (survival or complication free stay) or (death or complications). Results were analyzed in SPSS version 18. Results: Out of the 353 patients with mean age of 37.12 ± 15.45 years, 245 (69.4%) were males and 108 (30.6%) were females. Seventy ive patients (21.2%) had mild elevation of aminotransferases (twofold increases), 265 patients (75.1%) had moderate increases (three to fourfold), and 13 (3.7%) had severe (>4 fold increase). Alanine transaminase (ALT) was statistically higher in patients with septicemia, hepatic, and renal failure (p-value ≤0.05). Aspartate transaminase (AST) was higher in almost all complications. Prolonged hospital stay was associated with raised LFTs and greater complications and mortality. AST was found to be twice as much raised as ALT. Conclusion: AST and ALT were statistically higher in patients with worse outcome thus can lead to early recognition of high risk cases.

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“…Dengue virus (DENV) has four serotypes (DEN [1][2][3][4]. Currently, all the serotypes have difused in tropical and subtropical regions of the world [2].…”

Section: Dengue Virusmentioning

confidence: 99%

Assessment of Dengue Fever Severity Through Liver Function Test

Zubair¹,

Qureshi²,

Jafri³

2017

Dengue - Immunopathology and Control Strategies

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“…DENVs cause the most notable mosquito-borne viral disease in the world; ≈100 million infections occur annually worldwide, and the incidence has increased >30-fold in the past 50 years (1). Despite this tremendous expansion of both diseases, relatively few cases of Chikungunya fever have been reported in Africa (3,6,7), and few dengue-2 virus (DENV-2) epidemics have been reported (8,9). Simultaneous CHIKV and DENV-2 outbreaks have rarely been observed.…”

mentioning

confidence: 99%

Concurrent Chikungunya and Dengue Virus Infections during Simultaneous Outbreaks, Gabon, 2007

Leroy¹,

Nkoghe²,

Ollomo³

et al. 2009

Emerg. Infect. Dis.

209

184

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“…In endemic areas, where DHF incidence remains high, mosquito vectors are abundant and multiple in- p = 0.0162 fections are often thought to involve different serotypes (Gubler & Meltzer 1999, Thomas et al 2003, Suaya et al 2009). In addition, an analysis of repeated hospital admissions for dengue showed that at least 10% of repeat dengue admission patients may correspond to a third or fourth infection with all secondary admissions due to secondary dengue infection (Gibbons et al 2007).…”

mentioning

confidence: 99%

Environmental influences on antibody-enhanced dengue disease outcomes

Diniz

Fôro

Turiel³

et al. 2012

Mem. Inst. Oswaldo Cruz

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Because an enriched environment (EE) enhances T-cell activity and T-lymphocytes contribute to immunopathogenesis during heterologous dengue virus (DENV) infections, we hypothesised that an EE increases dengue severity. To compare single serotype (SS) and antibody-enhanced disease (AED) infections regimens, serial intraperitoneal were performed with DENV3 (genotype III) infected brain homogenate or anti-DENV2 hyperimmune serum followed 24 h later by DENV3 (genotype III) infected brain homogenate. Compared AED for which significant differences were detected between the EE and impoverished environmental (IE) groups (Kaplan-Meyer log-rank test, p = 0.0025), no significant differences were detected between the SS experimental groups (Kaplan-Meyer log-rank test, p = 0.089). Survival curves from EE and IE animals infected with the AED regimen were extended after corticoid injection and this effect was greater in the EE than in the IE group (Kaplan-Meyer log-rank test, p = 0.0162). Under the AED regimen the EE group showed more intense clinical signs than the IE group. Dyspnoea, tremor, hunched posture, ruffled fur, immobility, pre-terminal paralysis, shock and death were associated with dominant T-lymphocytic hyperplasia and presence of viral antigens in the liver and lungs. We propose that the increased expansion of these memory T-cells and serotype cross-reactive antibodies facilitates the infection of these cells by DENV and that these events correlate with disease severity in an EE

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Dengue Epidemiology: Virus Epidemiology, Ecology, And Emergence

Cited by 92 publications

References 215 publications

Assessment of Dengue Fever Severity Through Liver Function Test

Assessment of Dengue Fever Severity Through Liver Function Test

Concurrent Chikungunya and Dengue Virus Infections during Simultaneous Outbreaks, Gabon, 2007

Environmental influences on antibody-enhanced dengue disease outcomes

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