Dengue and COVID‐19, overlapping epidemics? An analysis from Colombia

Cardona-Ospina, Jaime A.; Arteaga‐Livias, Kovy; Villamil-Gómez, Wilmer E.; Pérez-Díaz, Carlos E.; Bonilla-Aldana, D. Katterine; Mondragón-Cardona, Álvaro; Solarte-Portilla, Marco A.; Martínez, Ernesto; Millán-Oñate, José; López‐Medina, Eduardo; López, Pío; Navarro, Juan Carlos; Perez‐Garcia, Luis; Mogollon-Rodriguez, Euler A.; Rodríguez‐Morales, Alfonso J.; Paniz‐Mondolfi, Alberto

doi:10.1002/jmv.26194

Cited by 89 publications

(95 citation statements)

References 25 publications

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“…From correlation analysis, there is a significant correlation (p<0.001, r=0.707). This finding can confirm a recent report from Colombia that there are overlapping epidemics between COVID-19 and dengue 2 . In a tropical country, children might be affected by both COVID-19 and dengue at the same time.…”

supporting

confidence: 92%

Dengue and COVID‐19, overlapping epidemics in highly endemic area

Joob¹,

Wiwanitkit

2020

Sri Lanka J Child Health

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supporting

confidence: 92%

Dengue and COVID‐19, overlapping epidemics in highly endemic area

Joob¹,

Wiwanitkit

2020

Sri Lanka J Child Health

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“…In healthcare systems facing overlapping epidemics of dengue and COVID-19, 25,26 our study highlights that adherence to a strict triage algorithm to differentiate the diseases is necessary for infection prevention and control, and the possibility of coinfection, although low, needs to be excluded thoroughly. 27 However, this strategy may not be easily emulated across all healthcare facilities universally.…”

Section: Experience Of Covid-19 During a Dengue Epidemicmentioning

confidence: 94%

Experience of a Tertiary Hospital in Singapore with Management of a Dual Outbreak of COVID-19 and Dengue

Wee

Cherng

Goh

et al. 2020

The American Journal of Tropical Medicine and Hygiene

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During the COVID-19 pandemic, distinguishing dengue from cases of COVID-19 in endemic areas can be difficult. In a tertiary hospital contending with COVID-19 during a dengue epidemic, a triage strategy of routine COVID-19 testing for febrile patients with viral prodromes was used. All febrile patients with viral prodromes and no epidemiologic risk for COVID-19 were first admitted to a designated ward for COVID-19 testing, where enhanced personal protective equipment was used by healthcare workers until COVID-19 was ruled out. From January to May 2020, 11,086 admissions were screened for COVID-19; 868 cases of COVID-19 were diagnosed in our institution, along with 380 cases of dengue. Only 8.5% (943/11,086) of suspected COVID-19 cases were concurrently tested for dengue serology due to a compatible overlapping clinical syndrome, and dengue was established as an alternative diagnosis in 2% (207/10,218) of suspected COVID-19 cases that tested negative. There were eight COVID-19 cases with likely false-positive dengue serology and one probable COVID-19/dengue coinfection. From April to May 2020, 251 admissions presenting as viral prodromes with no respiratory symptoms were screened; of those, 15 cases had COVID-19, and 2/15 had false-positive dengue IgM. Epidemiology investigations showed no healthcare-associated transmission. In a dengue epidemic season coinciding with a COVID-19 pandemic, dengue was established as an alternative diagnosis in a minority of COVID-19 suspects, likely due to early availability of basic diagnostics. Routine screening of patients with viral prodromes during a dual outbreak of COVID-19 and dengue enabled containment of COVID-19 cases masquerading as dengue with false-positive IgM.

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“…An animal study proved that the in-vivo blocking of angiotensin II type 1 receptor (AT1 receptor) by losartan and the inhibition of ACE using enalapril led to a reduction in the percentage of macrophages expressing DENV [6]. Their conclusion, combined with the fact that ACE2 can also facilitate SARS-CoV2 entry, suggested a viral interference of SARS-CoV-2 over the dengue virus [8]. RT-PCR is one of the major tests used for diagnosing viral infections.…”

Section: Discussionmentioning

confidence: 99%

A Patient With Dengue Fever and COVID-19: Coinfection or Not?

Malibari¹,

Al-Husayni²,

Jabri³

et al. 2020

Cureus

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Co-epidemics can create a burden on healthcare systems in the affected areas. The world, at present, is facing the pandemic of coronavirus disease. Nonetheless, many areas worldwide suffer from endemics that are not of less danger than the current pandemic. We presented a case of a patient diagnosed with dengue fever and was also found to have coronavirus through nasal swab, but immunoglobulin M and G were undetectable. Our case brings to notice the alarming probability of two co-epidemics happening simultaneously. However, through the presented case, our theory is that the dengue virus may cause a false-positive detection of severe acute respiratory syndrome coronavirus 2.

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Dengue and COVID‐19, overlapping epidemics? An analysis from Colombia

Cited by 89 publications

References 25 publications

Dengue and COVID‐19, overlapping epidemics in highly endemic area

Dengue and COVID‐19, overlapping epidemics in highly endemic area

Experience of a Tertiary Hospital in Singapore with Management of a Dual Outbreak of COVID-19 and Dengue

A Patient With Dengue Fever and COVID-19: Coinfection or Not?

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