Dendronpholides A−R, Cembranoid Diterpenes from the Chinese Soft Coral <i>Dendronephthya</i> sp.

Ma, Aiying; Deng, Zhiwei; Ofwegen, Leen van; Bayer, Mirko; Proksch, Peter; Lin, Wenhan

doi:10.1021/np800003w

Cited by 25 publications

(18 citation statements)

References 13 publications

(74 reference statements)

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“…Bioactive compounds such as terpenes were mainly in ethyl acetate extract [21]. The problem of signal overlap still existed in the spectra of ethyl acetate extract.…”

Section: Resultsmentioning

confidence: 99%

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NMR-Based Metabolomic Analysis of Spatial Variation in Soft Corals

Sun

Liu

et al. 2014

Marine Drugs

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Soft corals are common marine organisms that inhabit tropical and subtropical oceans. They are shown to be rich source of secondary metabolites with biological activities. In this work, soft corals from two geographical locations were investigated using 1H-NMR spectroscopy coupled with multivariate statistical analysis at the metabolic level. A partial least-squares discriminant analysis showed clear separation among extracts of soft corals grown in Sanya Bay and Weizhou Island. The specific markers that contributed to discrimination between soft corals in two origins belonged to terpenes, sterols and N-containing compounds. The satisfied precision of classification obtained indicates this approach using combined 1H-NMR and chemometrics is effective to discriminate soft corals collected in different geographical locations. The results revealed that metabolites of soft corals evidently depended on living environmental condition, which would provide valuable information for further relevant coastal marine environment evaluation.

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“…Bioactive compounds such as terpenes were mainly in ethyl acetate extract [21]. The problem of signal overlap still existed in the spectra of ethyl acetate extract.…”

Section: Resultsmentioning

confidence: 99%

“…reported an isolation of 18 new cembrane-type diterpenes, 11-episinulariolide and sandensolide from Dendronephthya sp. collected in Sanya Bay [21]. …”

Section: Resultsmentioning

confidence: 99%

NMR-Based Metabolomic Analysis of Spatial Variation in Soft Corals

Sun

Liu

et al. 2014

Marine Drugs

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“…Five new cembradiene diterpenoids (58)(59)(60)(61)(62)(63) have been isolated from an undescribed Caribbean gorgonian of the genus Eunicea [29]. Flabellatenes A (64), and B (65) have been isolated from the extract of the Antarctic sponge Lissodendoryx flabellata. Compound 64 was cytotoxic on mouse neuroblastoma cells (N18-T62) at low concentrations (0.16 μM), whereas significantly reduced cell proliferation of human tumoral cells (DU-145 and MCF-7) in a dose-depending manner [30].…”

Section: Isopropyl Cembranesmentioning

confidence: 99%

“…resulted in the isolation and characterization of 15 new cembranoid diterpenes, namely, dendronpholides C-F, I-P, R (171)(172)(173)(174)(175)(176)(177)(178)(179)(180)(181)(182)(183), sinulaflexiolides E, and F(184, 185). Dendronpholides C (171), and J (176) showed a selective and significant inhibition against BGC-823 (IC 50 = 0.05, 0.20 μg/mL, respectively) [65,66]. The soft coral Sinularia flexibilis produced an abundance of cembranoids, including flexibilisin A (186), and flexibilisin B (187) [67], sinulaflexiolides E-H (188-191) [43], sinuflexibilin (192) [68], sinuladiterpene I (193) [69], flexilarins B, and C (194, 195) [70].…”

Section: Isopropyl/ Isopropenyl Acid Cembranesmentioning

confidence: 99%

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Cembrane Diterpenes Chemistry and Biological Properties

Yang¹,

Zhou²,

Lin³

et al. 2012

COC

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Cembrane-type diterpenoids are a large and structurally varied group of natural products isolated from both terrestrial and marine organisms. The present paper reviews all the metabolites of cembrane diterpenes, reported up to 2010. The natural products discussed in this review can be divided into several different structural families featuring a variety of ring sizes and oxidation patterns. The currently known biological activities will be presented as well.

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Cnidaria and Ctenophora–2

Kornprobst

2014

Encyclopedia of Marine Natural Products

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The article contains sections titled: Membrane Constituents and Secondary Metabolites of Hexacorallia (Anthozoa) Fatty Acids, Oxylipins, and Acetylenic Derivatives Sterols and Ecdysteroids Terpenes Carotenoids of Sea Anemones Aromatic Derivatives Ceramides and Lipidic α‐Amino Acids Examples of Nitrogenous Pigments: Zoanthoxanthins and Calliactine Palytoxins ( PTXs ) Mycosporines Betaines, Phosphobetaines, Purines, and Other Nitrogen‐Containing Derivatives Zoanthamine Alkaloids Cytolysins, Neuropeptides, and Other Venoms of Sea Anemones Venoms and Other Metabolites of Medusozoa Some Data on the Cubozoa and Other Jellyfish Bioluminescence of Jellyfish and Other Cnidaria Some Results on the Secondary Metabolites of Other Hydrozoa Ctenophora

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Dendronpholides A−R, Cembranoid Diterpenes from the Chinese Soft Coral Dendronephthya sp.

Cited by 25 publications

References 13 publications

NMR-Based Metabolomic Analysis of Spatial Variation in Soft Corals

NMR-Based Metabolomic Analysis of Spatial Variation in Soft Corals

Cembrane Diterpenes Chemistry and Biological Properties

Cnidaria and Ctenophora–2

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