Dendronized Systems for the Delivery of Chemotherapeutics

Dockery, Lance T.; Daniel, Marie‐Christine

doi:10.1016/bs.acr.2018.04.003

Cited by 6 publications

(6 citation statements)

References 97 publications

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“…This methodology minimizes the occurrence of structural problems and facilitates the purification of the product [ 16 ]. Later, with the development of “click chemistry” [ 18 ], the preparation of dendronized systems became more efficient, requiring minimal purification [ 19 ]. She et al [ 20 ], for instance, synthetized G2-poly-L-lysine dendrons that were connected at the core to a heparin sulphate moiety via “click chemistry”, and doxorubicin (DOX) was conjugated to the terminal ends using acyl hydrazine.…”

Section: Dendrimer Nanoparticlesmentioning

confidence: 99%

A Glimpse into Dendrimers Integration in Cancer Imaging and Theranostics

Cruz

Barbosa

Antunes

et al. 2023

IJMS

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Cancer is a result of abnormal cell proliferation. This pathology is a serious health problem since it is a leading cause of death worldwide. Current anti-cancer therapies rely on surgery, radiation, and chemotherapy. However, these treatments still present major associated problems, namely the absence of specificity. Thus, it is urgent to develop novel therapeutic strategies. Nanoparticles, particularly dendrimers, have been paving their way to the front line of cancer treatment, mostly for drug and gene delivery, diagnosis, and disease monitoring. This is mainly derived from their high versatility, which results from their ability to undergo distinct surface functionalization, leading to improved performance. In recent years, the anticancer and antimetastatic capacities of dendrimers have been discovered, opening new frontiers to dendrimer-based chemotherapeutics. In the present review, we summarize the intrinsic anticancer activity of different dendrimers as well as their use as nanocarriers in cancer diagnostics and treatment.

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Section: Dendrimer Nanoparticlesmentioning

confidence: 99%

A Glimpse into Dendrimers Integration in Cancer Imaging and Theranostics

Cruz

Barbosa

Antunes

et al. 2023

IJMS

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“…Several plant secondary metabolites (phytochemicals) and their semi-synthetically derivatives have been approved and utilized as anticancer drugs or adjuvant of chemical medications; paclitaxel (syn. taxol), vinblastine, vincristine, camptothecin, and etoposide are the most effective natural-based drugs which widely prescribed for the treatment of various cancer types [ 3 , 4 , 5 , 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

The Promising Therapeutic and Preventive Properties of Anthocyanidins/Anthocyanins on Prostate Cancer

Mottaghipisheh

Doustimotlagh

Irajie

et al. 2022

Cells

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As water-soluble flavonoid derivatives, anthocyanidins and anthocyanins are the plants pigments mostly rich in berries, pomegranate, grapes, and dark color fruits. Many bioactivity properties of these advantageous phytochemicals have been reported; among them, their significant abilities in the suppression of tumor cells are of the promising therapeutic features, which have recently attracted great attention. The prostate malignancy, is considered the 2nd fatal and the most distributed cancer type in men worldwide. The present study was designated to gather the preclinical and clinical studies evaluating potencies of anthocyanidins/anthocyanins for the treatment and prevention of this cancer type for the first time. In general, findings confirm that the anthocyanins (especifically cyanidin-3-O-glucoside) indicated higher activity against prostatic neoplasms compared to their correlated anthocyanidins (e.g., delphinidin); in which potent anti-inflammatory, apoptosis, and anti-proliferative activities were analyzed. Complementary anti-prostate cancer assessment of diverse naturally occurred anthocyanidins/anthocyanins and their synthetically optimized derivatives through preclinical experiments and eventually confirmed by clinical trials can promisingly lead to discover natural-based chemotherapeutic drug options.

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“…Investigation of phytoconstituents has been the target of many researchers in order to determine their health benefits. So far, many phytochemicals have been developed and consumed as successful drugs for the treatment of a diverse range of ailments and disorders, specifically cancer types [5][6][7]. Among the varied phytochemical classifications, flavonoids have been introduced as one of the largest natural phenolic compounds with broad valuable biological properties [8,9].…”

Section: Introductionmentioning

confidence: 99%

Linarin, a Glycosylated Flavonoid, with Potential Therapeutic Attributes: A Comprehensive Review

et al. 2021

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Many flavonoids, as eminent phenolic compounds, have been commercialized and consumed as dietary supplements due to their incredible human health benefits. In the present study, a bioactive flavone glycoside linarin (LN) was designated to comprehensively overview its phytochemical and biological properties. LN has been characterized abundantly in the Cirsium, Micromeria, and Buddleja species belonging to Asteraceae, Lamiaceae, and Scrophulariaceae families, respectively. Biological assessments exhibited promising activities of LN, particularly, the remedial effects on central nervous system (CNS) disorders, whereas the remarkable sleep enhancing and sedative effects as well as AChE (acetylcholinesterase) inhibitory activity were highlighted. Of note, LN has indicated promising anti osteoblast proliferation and differentiation, thus a bone formation effect. Further biological and pharmacological assessments of LN and its optimized semi-synthetic derivatives, specifically its therapeutic characteristics on osteoarthritis and osteoporosis, might lead to uncovering potential drug candidates.

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Dendronized Systems for the Delivery of Chemotherapeutics

Cited by 6 publications

References 97 publications

A Glimpse into Dendrimers Integration in Cancer Imaging and Theranostics

A Glimpse into Dendrimers Integration in Cancer Imaging and Theranostics

The Promising Therapeutic and Preventive Properties of Anthocyanidins/Anthocyanins on Prostate Cancer

Linarin, a Glycosylated Flavonoid, with Potential Therapeutic Attributes: A Comprehensive Review

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