Dendroids: a building block for the synthesis of polymodal dendritic structures

Synthesis of 1,2,3-Triazole Derived Potential Peptidomimetics

“…Our strategy for the synthesis, follows the "dendroid" approach (21,22). This strategy involves placement of mimetics of the key residues around a central core.…”

Dendrimers Derived from 1 → 3 Branching Motifs

“…The 1 → 3 aryl-branched dendrons have, for the most part, been used as terminal groups, but herein are numerous examples in which the G2 and G3 dendrons have been created and utilized as internal units. Although not directly within this 1 → 3 aryl-branched family, a novel series of “dendroids” was created in which “differentially substituted 1,8-naphthalene and 1,2,3-trihydroxybenzene were prepared and represent a family of a → (b + c) → [(d + e) + (f + g)]” …”

Recipient of the RSC industrially-sponsored award for medicinal chemistry

“…I have termed these compounds as 'dendroids' (Greek: dendron, a tree). 3 An analogy to the properties of these novel molecules would be likened to the branches of a tree or the unfolding of an umbrella to fill a wide area of space. These molecules are able to be derivatised with the functional groups which correspond to the side-chains of the key amino acids found to contribute to binding affinities of the parent protein.…”

“…These molecules are then optimised by the introduction of further local conformational constraints and other pharmacophores. 3,4 The strategies that I have adopted for the design of these peptoids and dendroids have been stimulated by a range of concepts drawn from the fields of synthetic organic chemistry, principles of drug design, and biological concepts relating to the mode of action of therapeutic agents. My hope is that these ideas will serve as a catalyst for further drug discovery concepts that will lead to additional therapeutically useful agents for the future.…”