Synthesis of 1,2,3-Triazole Derived Potential Peptidomimetics

Abstract

In this study, synthesis of some new 1,2,3-triazole derived potential scaffold type peptidomimetics are described.

Synthesis and characterization of poly(N-vinyl-1,2,3-triazole)s derived from monomers obtained by highly efficient Wolff's cyclocondensation

“…19,20 Nonetheless, this methodology still suffers shortcomings such as the use of highly polar solvents, large amounts of catalysts and highly reactive reactants, as well as relatively low yields. [21][22][23][24] More recently, the efficiency of Wolff's cyclocondensation was greatly enhanced by introducing an intramolecular hydrogen bonding-activated carbonyl group. 25,26 This modification successfully solved the challenging problem of low yields in Wolff 1,2,3-triazole synthesis, and constituted a powerful methodology for the synthesis of highly functionalized 1,2,3-triazoles.…”

The Application of “Click Chemistry” for the Decoration of 2(1H)-Pyrazinone Scaffold: Generation of Templates

“…1,2,3-Triazoles are important target molecules due to their widespread use and importance as potent pharmacophores 1c and some N-substituted phenyl-1,2,3-triazole-4-acylhydrazones show significant antiplatelet activity on arachidonic acid- and collagen-induced platelet aggregation 1b.…”

“…1,2,3-Triazoles are important target molecules due to their widespread use and importance as potent pharmacophores 1c and some N-substituted phenyl-1,2,3-triazole-4-acylhydrazones show significant antiplatelet activity on arachidonic acid- and collagen-induced platelet aggregation 1b. Furthermore, 1,2,3-triazoles have found extensive industrial use as corrosion inhibitors, dyes, photostabilizers, photographic materials, and agrochemicals .…”

Synthesis and polymerization of C-vinyl- and N-vinyl-1,2,3-triazoles

“…12 Synthesis of 1-vinyl-1,2,3-triazoles by a condensation and elimination strategy Dabak and Akar have reported the condensation of thiophene and ethyl ester functionalized a-diazo-b-oxoaldehyde derivatives with 2-bromoethyl-amine in the presence of potassium acetate to afford the corresponding 4-substituted-1-bromoethyl-1,2,3-triazoles (Scheme 16). 14 Further elimination of hydrobromic acid in the presence of NaOH or EtONa yielded respectively 1VTs 59 and 60 in 75% yield. However, the harsh conditions for the elimination step and the limited availability of a-diazo-b-oxoaldehydes significantly restrict the range of application of this chemical pathway.…”

“…13 Scheme 16 Synthesis of 4-vinyl-1,2,3-triazoles by condensation and elimination strategies. 14 Scheme 17 Library of 1-vinyl-1,2,3-triazoles obtained by Hawker and co-workers using an elimination strategy. 15 Owing to triazole rings ability to bind metal species, 16 atom transfer radical polymerization has not yet been applied to the synthesis of such materials.…”