Dendritic Scaffold onto Titanium Implants. A Versatile Strategy Increasing Biocompatibility

Molina, Noemí; González, Ana Fernández; Monopoli, Donato; Mentado, Belinda; Becerra, José; Santos-Ruíz, Leonor; Vida, Yolanda; Pérez‐Inestrosa, Ezequiel

doi:10.3390/polym12040770

Cited by 8 publications

(12 citation statements)

References 53 publications

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“…At present, the osseointegration of titanium implants is a problem that remains to be solved. Molina et al [ 63 ] immobilized covalent dendrimers on titanium implants, synthesized amide-based amino-terminal dendrites, and coupled them to the titanium surface in a controllable manner. The dendritic portion anchored to the implant surface provides a scaffold for extracellular matrix (ECM) protein components that facilitate cell adhesion and proliferation.…”

Section: Metallic Biomaterials For Ammentioning

confidence: 99%

A Critical Review of Additive Manufacturing Techniques and Associated Biomaterials Used in Bone Tissue Engineering

Lyu

Zhao

et al. 2022

Polymers

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With the ability to fabricate complex structures while meeting individual needs, additive manufacturing (AM) offers unprecedented opportunities for bone tissue engineering in the biomedical field. However, traditional metal implants have many adverse effects due to their poor integration with host tissues, and therefore new material implants with porous structures are gradually being developed that are suitable for clinical medical applications. From the perspectives of additive manufacturing technology and materials, this article discusses a suitable manufacturing process for ideal materials for biological bone tissue engineering. It begins with a review of the methods and applicable materials in existing additive manufacturing technologies and their applications in biomedicine, introducing the advantages and disadvantages of various AM technologies. The properties of materials including metals and polymers, commonly used AM technologies, recent developments, and their applications in bone tissue engineering are discussed in detail and summarized. In addition, the main challenges for different metallic and polymer materials, such as biodegradability, anisotropy, growth factors to promote the osteogenic capacity, and enhancement of mechanical properties are also introduced. Finally, the development prospects for AM technologies and biomaterials in bone tissue engineering are considered.

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Section: Metallic Biomaterials For Ammentioning

confidence: 99%

A Critical Review of Additive Manufacturing Techniques and Associated Biomaterials Used in Bone Tissue Engineering

Lyu

Zhao

et al. 2022

Polymers

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“…1,2 However, titanium alloys are susceptible to bacterial infections, leading to complications or even fixation failure. 3 Postsurgical infection is one of the most dreaded problems of orthopedic procedures. 4 For addressing the problem of postsurgical infection, the clinical treatment for patients often relies on long-term antibiotics and multiple surgical debridement procedures, which causes the generation and spreading of multidrug-resistant (MDR) bacteria and causes pain and suffering to patients and heavy economic burden to the family and society.…”

Section: Introductionmentioning

confidence: 99%

In Situ Construction of Black Titanium Oxide with a Multilevel Structure on a Titanium Alloy for Photothermal Antibacterial Therapy

Yang

Zhang

et al. 2022

ACS Biomater. Sci. Eng.

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Postsurgical infection of orthopedic fixation materials is considered to be the main cause of fixation failure. To address the problem, clinical treatment often relies on long-term antibiotics, secondary surgery, and so forth, which cause pain and suffering to patients. Constructing a light-responsive surface structure on the implant has attracted widespread attention for the management of postsurgical infections because of its noninvasiveness and controllability. Nevertheless, the application of light-responsive structures on implants is still limited by their unsafety and instability. In this work, a black titanium oxide layer with a multilevel structure and lattice defects was in situ constructed on a titanium alloy through pulsed laser ablation treatment. Under the synergistic effect of the multilevel structure and crystal defects, the surface of the titanium alloy exhibited good near-infrared light-responsive photothermal ability. The black titanium oxide multilevel structure reached high antibacterial efficiencies of about 99.37 and 99.29% against Staphylococcus aureus and Escherichia coli under 10 min near-infrared light irradiation. Furthermore, the black titanium oxide layer possessed similar biocompatibility compared with the titanium alloy. This near-infrared light-responsive photothermal therapy based on the construction of a multilevel structure and introduction of lattice defects provides an effective strategy for clinical postsurgical infections of orthopedic fixation.

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“…The success rate of dental implants depends on osseointegration, which is initiated by cell adhesion when the implant surface meets the surrounding tissue [1][2][3][4][5][6][7]. Osseointegration failure is characterized by the instability or loosening of the implant, periimplantitis, and bone resorption [1,[8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

“…The ability of RGD peptides to bind with integrin receptors leads to increased cell adhesion and its functions [6,20]. It was reported that the tetrapeptide Gly-Arg-Gly-Asp (GRGD) peptide sequence derived from fibronectins will bind to integrins and other ECM proteins [5]. Moreover, the GRGD peptide was also reported to be useful in modifying the Ti implant surface [21].…”

Section: Introductionmentioning

confidence: 99%

The Potential of a Surface-Modified Titanium Implant with Tetrapeptide for Osseointegration Enhancement

Syam

Lan

et al. 2021

Applied Sciences

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In this study, the innovative dip-coating technique treated titanium (IDCT-Ti) implant with tetrapeptide Gly-Arg-Gly-Asp (GRGD) coating was investigated for its potential to enhance osseointegration. The L929 fibroblast cells were cultured in different concentrations of the GRGD (1%, 2%, and 5%). The cell viability was assessed through 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT) assay and live/dead staining. The surface topography and nano-indentation were analyzed by atomic force microscopy. The hemocompatibility was evaluated via field-emission scanning electron microscopy, while contact angle analysis was detected by a goniometer. Radiograph evaluation was determined by panoramic imaging. It was found that the cell growth increased and had a survival rate of more than 70% in 1% GRGD. The mortality of L929 increased with the higher concentration of GRGD. The IDCT-Ti coated with 1% GRGD showed a nano-surface with a Young’s modulus that was similar to human cortical bone, and it displayed greater red blood cell accumulations with abundant fibrin formation. As regards the wettability, the IDCT-Ti coated with 1% GRGD was lower than the SLA (sandblasted, large-grit, and acid-etched) treated implant. The X-ray image exhibited no bone loss around the implant at six months after placement. As a result, this study suggests that the IDCT-Ti implant, coated with 1% GRGD, has a tremendous likeliness to enhance osseointegration.

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Dendritic Scaffold onto Titanium Implants. A Versatile Strategy Increasing Biocompatibility

Cited by 8 publications

References 53 publications

A Critical Review of Additive Manufacturing Techniques and Associated Biomaterials Used in Bone Tissue Engineering

A Critical Review of Additive Manufacturing Techniques and Associated Biomaterials Used in Bone Tissue Engineering

In Situ Construction of Black Titanium Oxide with a Multilevel Structure on a Titanium Alloy for Photothermal Antibacterial Therapy

The Potential of a Surface-Modified Titanium Implant with Tetrapeptide for Osseointegration Enhancement

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