Dendritic Cells as Danger-Recognizing Biosensors

Gi, Mia; Im, Wooseok; Hong, Seokmann

doi:10.3390/s90906730

Cited by 11 publications

(7 citation statements)

References 71 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Chemokine receptor, CXCR5 (CXCL13) [72,73]; cytokine-receptors, TSLP receptor (CRLF2 and IL-7Rα) [74,75], IL-25R, and IL-33R (ST2); inducible costimulatory molecules ICOS (B7h) [76], OX40/OX40L [75], CD30/CD30L [77], and TIM1/TIM4 [78,79]; pattern recognition receptors (PRRs; TLR2, 3 and 4) [71]; c-type lectin receptors (Dectin-2, MGL, MR, DC-SIGN) [80,81]; RIG-l-like receptors (MDA5, LGP2) [82]; and protease-activated receptors (PAR 1–3) [83] are preferentially expressed on Th2-inducing DCs in both the human and mouse. Damage-associated molecular patterns (DAMP) receptors [84], including complement receptors (hCR1, hCR2, hCR3, mC3aR, mC5aR), prostanoid receptors (DP1, EP2, EP4, IP) [85], neuropeptide receptors (NK1, CGRPR) [86], purinergic receptors (P2X, P2Y) [87], HMGB1 receptor (RAGE) [88], and heat shock protein receptors (CD14, CD36, CD91) [89,90], are also preferentially expressed on Th2-inducing DCs.…”

Section: Genetic Factors Required For Cdc2 Development and Th2 Immmentioning

confidence: 99%

Dendritic Cell-Mediated Th2 Immunity and Immune Disorders

Kumar

Jeong

Ashraf

et al. 2019

IJMS

View full text Add to dashboard Cite

Dendritic cells (DCs) are the professional antigen-presenting cells that recognize and present antigens to naïve T cells to induce antigen-specific adaptive immunity. Among the T-cell subsets, T helper type 2 (Th2) cells produce the humoral immune responses required for protection against helminthic disease by activating B cells. DCs induce a Th2 immune response at a certain immune environment. Basophil, eosinophil, mast cells, and type 2 innate lymphoid cells also induce Th2 immunity. However, in the case of DCs, controversy remains regarding which subsets of DCs induce Th2 immunity, which genes in DCs are directly or indirectly involved in inducing Th2 immunity, and the detailed mechanisms underlying induction, regulation, or maintenance of the DC-mediated Th2 immunity against allergic environments and parasite infection. A recent study has shown that a genetic defect in DCs causes an enhanced Th2 immunity leading to severe atopic dermatitis. We summarize the Th2 immune-inducing DC subsets, the genetic and environmental factors involved in DC-mediated Th2 immunity, and current therapeutic approaches for Th2-mediated immune disorders. This review is to provide an improved understanding of DC-mediated Th2 immunity and Th1/Th2 immune balancing, leading to control over their adverse consequences.

show abstract

Section: Genetic Factors Required For Cdc2 Development and Th2 Immmentioning

confidence: 99%

Dendritic Cell-Mediated Th2 Immunity and Immune Disorders

Kumar

Jeong

Ashraf

et al. 2019

IJMS

View full text Add to dashboard Cite

show abstract

“…This fact may be explained by the particulate nature of HE (liposome-like), and the high content of LPS in the HE extract. It is known that LPS is recognized by TLR-4 [74]. Nevertheless, long-term memory and challenge studies should be performed in order to verify whether NP-HE could improve the immunological response, in spite of a similar antibody-mediated response.…”

Section: In Vivo Evaluation Of the Immune Response In Balb/c Micementioning

confidence: 99%

Chitosan/sulfated locust bean gum nanoparticles: In vitro and in vivo evaluation towards an application in oral immunization

Braz

Grenha

Ferreira

et al. 2017

International Journal of Biological Macromolecules

View full text Add to dashboard Cite

This work proposes the design of nanoparticles based on locus bean gum (LBG) and chitosan to be used as oral immunoadjuvant for vaccination purposes. LBG-based nanoparticles were prepared by mild polyelectrolyte complexation between chitosan (CS) and a synthesized LBG sulfate derivative (LBGS). Morphological characterization suggested that nanoparticles present a solid and compact structure with spherical-like shape. Sizes around 180-200nm and a positive surface charge between +9mV and +14mV were obtained. CS/LBGS nanoparticles did not affect cell viability of Caco-2 cells after 3h and 24h of exposure when tested at concentrations up to 1.0mg/mL. Two model antigens (a particulate acellular extract HE of Salmonella enterica serovar Enteritidis, and ovalbumin as soluble antigen) were associated to CS/LBGS nanoparticles with efficiencies around 26% for ovalbumin and 32% for HE, which resulted in loading capacities up to 12%. The process did not affect the antigenicity of the associated antigens. BALB/c mice were orally immunized with ovalbumin-loaded nanoparticles (100μg), and results indicate an adjuvant effect of the CS/LBGS nanoparticles, eliciting a balanced Th1/Th2 immune response. Thus, CS/LBGS nanoparticles are promising as antigen mucosal delivery strategy, with particular interest for oral administration.

show abstract

“…DM is frequently associated to PRR and innate immune response; also it is commonly linked to the recognition of microbial structures (danger signals) by immune cells through antigen nondiscriminating receptors [ 12 , 17 , 18 ]. Mostly, the DM is connoted as an array of archaic or rudimentary mechanisms.…”

Section: The Danger Model Boundariesmentioning

confidence: 99%

The Danger Model Approach to the Pathogenesis of the Rheumatic Diseases

Pacheco‐Tena

González-Chávez

2015

Journal of Immunology Research

View full text Add to dashboard Cite

The danger model was proposed by Polly Matzinger as complement to the traditional self-non-self- (SNS-) model to explain the immunoreactivity. The danger model proposes a central role of the tissular cells' discomfort as an element to prime the immune response processes in opposition to the traditional SNS-model where foreignness is a prerequisite. However recent insights in the proteomics of diverse tissular cells have revealed that under stressful conditions they have a significant potential to initiate, coordinate, and perpetuate autoimmune processes, in many cases, ruling over the adaptive immune response cells; this ruling potential can also be confirmed by observations in several genetically manipulated animal models. Here, we review the pathogenesis of rheumatic diseases such as systemic lupus erythematous, rheumatoid arthritis, spondyloarthritis including ankylosing spondylitis, psoriasis, and Crohn's disease and provide realistic approaches based on the logic of the danger model. We assume that tissular dysfunction is a prerequisite for chronic autoimmunity and propose two genetically conferred hypothetical roles for the tissular cells causing the disease: (A) the Impaired cell and (B) the paranoid cell. Both roles are not mutually exclusive. Some examples in human disease and in animal models are provided based on current evidence.

show abstract

Dendritic Cells as Danger-Recognizing Biosensors

Cited by 11 publications

References 71 publications

Dendritic Cell-Mediated Th2 Immunity and Immune Disorders

Dendritic Cell-Mediated Th2 Immunity and Immune Disorders

Chitosan/sulfated locust bean gum nanoparticles: In vitro and in vivo evaluation towards an application in oral immunization

The Danger Model Approach to the Pathogenesis of the Rheumatic Diseases

Contact Info

Product

Resources

About