Dendritic Cell-Mediated Th2 Immunity and Immune Disorders

Kumar, Sunil; Jeong, Yideul; Ashraf, Muhammad; Bae, Yong-Soo

doi:10.3390/ijms20092159

Cited by 67 publications

(26 citation statements)

References 226 publications

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“…Eosinophilia was significantly more frequent among children infected with Ascaris lumbricoides, Evermicularis, and H nana. Similar observations were reported by other studies 28,[34][35][36][37] .This could be explained by presence of tissue-invading larvae that migrate from the small intestine into blood circulation to reach lungs and elicit pulmonary inflammation 4, 38-40 . Nevertheless, eosinophilia was non-significant among schoolchildren infected with Trichuris trichiura and Taeniasaginata.…”

Section: Discussionsupporting

confidence: 81%

Prevalence of Intestinal Helminthiasis and Their Association With Eosinophilia Among Schoolchildren in Wadidhahar District at Sana’a Governorate, Yemen

Othman

Al-Mekhalfi

2020

Univ J Pharm Res

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Objectives: Allergy and parasitic infections are common causes of blood eosinophilia. Intestinal helminthiasis remains a major health problem in many developing countries. Eosinophils are an effector immune cell against parasites.The objective of this study was to determine the prevalence of intestinal helminthiasis and eosinophilia among primary schoolchildren in WadiDhahr district, Sana’a governorate, Yemen. Subjects and methods: Four hundred and fourteen pupils were enrolled in this study. Blood and stool samples were collected from each pupil. Stool samples were examined using Hoffman’s sedimentation method for the presence of worms’ ova.Blood smears were stained with Giemsa stain and used for counting the eosinophils’ percentages. Results: Out of 414 specimens, the prevalence of intestinal helminths infections was 79(19%) among schoolchildren; (52 (18%) males and 27 (21%) females). Eosinophilia was 134 (32%) observed in the participated pupils; 86 (30%) males and 48 (37%) females. The age group 5-10 years had the highest frequent rate of eosinophilia with a statistically significant difference (χ2 = 10.4, P = 0.002) and 60% of infected students with intestinal worms had eosinophilia (χ2 = 32.8, P< 0.001). Females had a higher rate of eosinophilia than males. The most common helminthiasis infections were hymenolepiasis (10.6%) followed by ascariasis (4.1%), enterobiasis (2.7%), and taeniasis (2.4%). The high rate of eosinophilia was recorded among students infected with Ascaris lumbricoides (82%) followed by Enterobius vermicularis (73%), Trichuristrichiura(67%), Hymenolepis nana (59%), and Taeniasaginata (30%). Conclusions: Intestinal helminthiasis still a common health problem among schoolchildrenin WadiDhahar district at Sana’a governorate, Yemen, and was found to be associated with high blood eosinophils. Eosinophilia was statistically significant among students infected with ascariasis, hymenolepiasis, and enterobiasis but not with taeniasis and trichuriasis. Peer Review History: Received 12 July 2020; Revised 14 August; Accepted 27 August, Available online 15 September 2020 UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency. Received file Average Peer review marks at initial stage: 6.5/10 Average Peer review marks at publication stage: 8.0/10 Reviewer(s) detail: Name: Dr. Wadhah Hassan Edrees Affiliation: Hajjah University, Yemen E-mail: edress2020@gmail.com Name: Omnia Momtaz Al-Fakharany Affiliation: E-mail: amina.elfakharany@pharm.tanta.edu.eg Comments of reviewer(s): Similar Articles: FREQUENCY OF INTESTINAL PARASITIC INFECTIONS AMONG SCHOOLCHILDREN IN IBB CITY-YEMEN PREVALENCE AND CAUSES OF TRAUMATIC DENTAL INJURIES TO ANTERIOR TEETH AMONG PRIMARY SCHOOL CHILDREN IN SANA'A CITY, YEMEN

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Section: Discussionsupporting

confidence: 81%

Prevalence of Intestinal Helminthiasis and Their Association With Eosinophilia Among Schoolchildren in Wadidhahar District at Sana’a Governorate, Yemen

Othman

Al-Mekhalfi

2020

Univ J Pharm Res

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“…Cytokine secretion activated by T-cells is regulated by transcription factors, including NF-κB, which activate the expression of genes encoding pro-inflammatory cytokines and chemokines [ 24 ]. NF-κB is critical to the innate/adaptive immune response and inflammatory response, especially the Th1 response, and regulates inflammation caused by Th2 cell differentiation and activation [ 25 ]. We determined NF-κB activation in DNCB-induced mice by Western blotting.…”

Section: Resultsmentioning

confidence: 99%

Impressic Acid Ameliorates Atopic Dermatitis-Like Skin Lesions by Inhibiting ERK1/2-Mediated Phosphorylation of NF-κB and STAT1

Choi

Lee

Jin

et al. 2021

IJMS

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Impressic acid (IPA), a lupane-type triterpenoid from Acanthopanax koreanum, has many pharmacological activities, including the attenuation of vascular endothelium dysfunction, cartilage destruction, and inflammatory diseases, but its influence on atopic dermatitis (AD)-like skin lesions is unknown. Therefore, we investigated the suppressive effect of IPA on 2,4-dinitrochlorobenzene (DNCB)-induced AD-like skin symptoms in mice and the underlying mechanisms in cells. IPA attenuated the DNCB-induced increase in the serum concentrations of IgE and thymic stromal lymphopoietin (TSLP), and in the mRNA levels of thymus and activation regulated chemokine(TARC), macrophage derived chemokine (MDC), interleukin-4 (IL-4), interleukin-5 (IL-5), interleukin-13 (IL-13), tumor necrosis factor-alpha (TNF-α) and interferon-gamma (IFN-γ) in mice. Histopathological analysis showed that IPA reduced the epidermal/dermal thickness and inflammatory and mast cell infiltration of ear tissue. In addition, IPA attenuated the phosphorylation of NF-κB and IκBα, and the degradation of IκBα in ear lesions. Furthermore, IPA treatment suppressed TNF-α/IFN-γ-induced TARC expression by inhibiting the NF-κB activation in cells. Phosphorylation of extracellular signalregulated protein kinase (ERK1/2) and the signal transducer and activator of transcription 1 (STAT1), the upstream signaling proteins, was reduced by IPA treatment in HaCaT cells. In conclusion, IPA ameliorated AD-like skin symptoms by regulating cytokine and chemokine production and so has therapeutic potential for AD-like skin lesions.

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“…In type 1 hypersensitivity reactions, antigen-presenting cells (APCs), mainly dendritic cells (DCs), control the differentiation of naïve T helper cells into effector T cells, such as Th1 or Th2 cells, depending on the nature and source of the antigen [17,18]. Upon initial allergen encounter, Th2 polarization, a hallmark of allergic sensitization, is triggered by interleukin 4 (IL-4) signalling and characterized by the secretion of Th2-associated cytokines (IL-4, IL-5 and IL-13) [19]. While IL-4 has a key role in the initiation of sensitization, IL-5 and IL-13 are relevant in later stages of the sensitization process as well as the effector phase.…”

Section: Ige-mediated Allergic Immune Responsementioning

confidence: 99%

Initiating pollen sensitization – complex source, complex mechanisms

Pointner

Bethanis

Thaler

et al. 2020

Clin Transl Allergy

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The mechanisms involved in the induction of allergic sensitization by pollen are not fully understood. Within the last few decades, findings from epidemiological and experimental studies support the notion that allergic sensitization is not only dependent on the genetics of the host and environmental factors, but also on intrinsic features of the allergenic source itself. In this review, we summarize the current concepts and newest advances in research focusing on the initial mechanisms inducing pollen sensitization. Pollen allergens are embedded in a complex and heterogeneous matrix composed of a myriad of bioactive molecules that are co-delivered during the allergic sensitization. Surprisingly, several purified allergens were shown to lack inherent sensitizing potential. Thus, growing evidence supports an essential role of pollen-derived components co-delivered with the allergens in the initiation of allergic sensitization. The pollen matrix, which is composed by intrinsic molecules (e.g. proteins, metabolites, lipids, carbohydrates) and extrinsic compounds (e.g. viruses, particles from air pollutants, pollen-linked microbiome), provide a specific context for the allergen and has been proposed as a determinant of Th2 polarization. In addition, the involvement of various pattern recognition receptors (PRRs), secreted alarmins, innate immune cells, and the dependency of DCs in driving pollen-induced Th2 inflammatory processes suggest that allergic sensitization to pollen most likely results from particular combinations of pollen-specific signals rather than from a common determinant of allergenicity. The exact identification and characterization of such pollen-derived Th2-polarizing molecules should provide mechanistic insights into Th2 polarization and pave the way for novel preventive and therapeutic strategies against pollen allergies.

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Dendritic Cell-Mediated Th2 Immunity and Immune Disorders

Cited by 67 publications

References 226 publications

Prevalence of Intestinal Helminthiasis and Their Association With Eosinophilia Among Schoolchildren in Wadidhahar District at Sana’a Governorate, Yemen

Prevalence of Intestinal Helminthiasis and Their Association With Eosinophilia Among Schoolchildren in Wadidhahar District at Sana’a Governorate, Yemen

Impressic Acid Ameliorates Atopic Dermatitis-Like Skin Lesions by Inhibiting ERK1/2-Mediated Phosphorylation of NF-κB and STAT1

Initiating pollen sensitization – complex source, complex mechanisms

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