Dendritic cells and macrophages in the genitourinary tract

Iijima, Norifumi; Thompson, Jeff. E.; Iwasaki, Akiko

doi:10.1038/mi.2008.57

Cited by 79 publications

(74 citation statements)

References 108 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In addition to the adaptive immune response, cells associated with innate immunity also have a protective role, including neutrophils (38), NK cells, and NKT cells (4). Furthermore, pattern recognition receptors, including Toll-like receptors (TLRs), have been found to drive a Th1 protective response following genital HSV-2 infection (28). Synthetic CpG-containing oligonucleotides that activate TLRs have been experimentally used to induce an antiviral state following vaginal instillation (5,21,52).…”

mentioning

confidence: 99%

Loss of the Type I Interferon Pathway Increases Vulnerability of Mice to Genital Herpes Simplex Virus 2 Infection

Conrady

Halford

Carr

2011

J Virol

View full text Add to dashboard Cite

The mouse model of genital herpes relies on medoxyprogesterone treatment of female mice to render the vaginal lumen susceptible to inoculation with herpes simplex virus 2 (HSV-2). In the present study, we report that mice deficient in the A1 chain of the type I interferon receptor (CD118 ؊/؊ ) are susceptible to HSV-2 in the absence of medroxyprogesterone preconditioning. In the absence of hormone pretreatment, 2,000 PFU of a clinical isolate of HSV-2 was sufficient to establish a productive infection in the vagina of 75% ؎ 17% and in the spinal cord of 71% ؎ 14% of CD118 ؊/؊ mice, whereas the same dose of HSV-2 replicated to detectable levels in only 13% ؎ 13% of vaginal samples and 0% of spinal cord samples from wild-type mice, as determined at day 5 postinfection. The susceptibility to HSV-2 infection in the CD118 ؊/؊ mice was associated with a significant reduction in the infiltration of HSV-specific cytotoxic T lymphocytes into the vaginal tissue, the local production of gamma interferon (IFN-␥), and the expression of T cell-recruiting chemokines CCL5, CXCL9, and CXCL10. Collectively, the results underscore the significant contribution of type I IFNs in resistance to genital HSV-2 infection.

show abstract

mentioning

confidence: 99%

Loss of the Type I Interferon Pathway Increases Vulnerability of Mice to Genital Herpes Simplex Virus 2 Infection

Conrady

Halford

Carr

2011

J Virol

View full text Add to dashboard Cite

show abstract

“…Then, an antigen-specific attack is launched by the adaptive arm of the immune system, consisting of T and B cells, after the microbial antigens have been recognized, processed and presented by antigen presenting cells [181,190,191]. The cross-talk between the innate and the adaptive immune systems, as well as the important role that T and B cells play in conferring long-term immunity in the genital tract, have been discussed previously [181,183,195].…”

Section: Accepted M Manuscriptmentioning

confidence: 99%

“…The humoral immune compartment of the human genital tract exhibits features which are unique and functionally different from other compartments of the mucosal immune system [181,190,191,194]. The main immunoglobulin (Ig) isotype found in the lumen of the upper FGT is IgA as in other mucosal tissues [185].…”

Section: Accepted M Manuscriptmentioning

confidence: 99%

See 1 more Smart Citation

Profiles and technological requirements of urogenital probiotics

Nader‐Macías

Tomás

2015

Advanced Drug Delivery Reviews

View full text Add to dashboard Cite

Probiotics, defined as live microorganisms that, when administered in adequate amounts, confer a health benefit on the host, are considered a valid and novel alternative for the prevention and treatment of female urogenital tract infections. Lactobacilli, the predominant microorganisms of the healthy human vaginal microbiome, can be included as active pharmaceutical ingredients in probiotics products. Several requirements must be considered or criteria fulfilled during the development of a probiotic product or formula for the female urogenital tract. This review deals with the main selection criteria for urogenital probiotic microorganisms: host specificity, potential beneficial properties, functional specifications, technological characteristics and clinical trials used to test their effect on certain physiological and pathological conditions. Further studies are required to complement the current knowledge and support the clinical applications of probiotics in the urogenital tract. This therapy will allow the restoration of the ecological equilibrium of the urogenital tract microbiome as well as the recovery of the sexual and reproductive health of women.Fil: Nader, Maria Elena Fatima. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Centro de Referencia Para Lactobacilos; ArgentinaFil: Juárez Tomás, María Silvina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Centro de Referencia Para Lactobacilos; Argentin

show abstract

“…This epithelium offers a physical barrier for infection. The mucus secreting cells present in the mucosa prevent entry of harmful bacteria [7]. In addition to this, defense at mucosal surface is mediated through humoral and cell mediated immunity.…”

Section: Introductionmentioning

confidence: 99%