Dendritic cells and lymphocyte subpopulations of the adenoid in the pathogenesis of otitis media with effusion

Kotowski, Michał; Niedzielski, Artur; Niedzielska, G; Lachowska-Kotowska, Patrycja

doi:10.1016/j.ijporl.2010.11.014

Cited by 16 publications

(8 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…According to Zelazowska‐Rutkowska and colleagues, 228 reduced proportions of T and B lymphocytes with Bcl‐2 expression but elevated percentages expressing CD95 + may reflect local immunity disorders. In another study, the populations of dendritic cells and lymphocyte subpopulations of adenoid and peripheral blood in patients with adenoid hypertrophy and otitis media with effusion (OME) found differences between patients with adenoid hypertrophy with coexisting OME and children without OME in the adenoids but not in blood 229 . Local induction of inducible nitric oxide synthase (iNOS) in adenoids has also been suggested to be of importance for preventing development of OME following evidence that children with OME exhibited lower levels of iNOS than controls 230 .…”

Section: Discussionmentioning

confidence: 98%

“…In another study, the populations of dendritic cells and lymphocyte subpopulations of adenoid and peripheral blood in patients with adenoid hypertrophy and otitis media with effusion (OME) found differences between patients with adenoid hypertrophy with coexisting OME and children without OME in the adenoids but not in blood. 229 Local induction of inducible nitric oxide synthase (iNOS) in adenoids has also been suggested to be of importance for preventing development of OME following evidence that children with OME exhibited lower levels of iNOS than controls. 230 Inducible nitric oxide synthase is one of the enzymes that regulates production of nitric oxide, a key mediator in the local immune response of human airways.…”

Section: Immunologymentioning

confidence: 99%

See 1 more Smart Citation

Panel 5: Microbiology and Immunology Panel

Murphy

Chonmaitree

Barenkamp

et al. 2013

Otolaryngol.--head neck surg.

View full text Add to dashboard Cite

Objective The objective is to perform a comprehensive review of the literature from January 2007 through June 2011 on the virology, bacteriology, and immunology related to otitis media. Data Sources PubMed database of the National Library of Medicine. Review Methods Three subpanels with co-chairs comprising experts in the virology, bacteriology, and immunology of otitis media were formed. Each of the panels reviewed the literature in their respective fields and wrote draft reviews. The reviews were shared with all panel members, and a second draft was created. The entire panel met at the 10th International Symposium on Recent Advances in Otitis Media in June 2011 and discussed the review and refined the content further. A final draft was created, circulated, and approved by the panel. Conclusion Excellent progress has been made in the past 4 years in advancing an understanding of the microbiology and immunology of otitis media. Advances include laboratory-based basic studies, cell-based assays, work in animal models, and clinical studies. Implications for Practice The advances of the past 4 years formed the basis of a series of short-term and long-term research goals in an effort to guide the field. Accomplishing these goals will provide opportunities for the development of novel interventions, including new ways to better treat and prevent otitis media.

show abstract

Section: Discussionmentioning

confidence: 98%

Section: Immunologymentioning

confidence: 99%

Panel 5: Microbiology and Immunology Panel

Murphy

Chonmaitree

Barenkamp

et al. 2013

Otolaryngol.--head neck surg.

View full text Add to dashboard Cite

show abstract

“…CD69 is an early inducible cell surface glycoprotein during lymphoid activation with changes to its expression indicating reduced T‐cell activation. It has been found that dendritic cells and lymphocytes from adenoid and peripheral blood in older children with AH and OME 75 were lower for CD3 + CD69 + , CD4 + CD69 + , CD8 + CD69 + , and CD19 + CD69 + cells in adenoids from OME, suggesting reduced T‐cell activation. Differences were also observed between cells from the adenoids and peripheral blood in patients with OME for BDCA‐2 + /CD123 + cells and CD3 + and CD19 + activation markers.…”

Section: Discussionmentioning

confidence: 99%

“…It has been found that dendritic cells and lymphocytes from adenoid and peripheral blood in older children with AH and OME 75 were lower for CD3 1 CD69…”

Section: Adaptive Immunitymentioning

confidence: 99%

Panel 5: Immunology

Kyd

Hotomi

Kono

et al. 2017

Otolaryngol.--head neck surg.

View full text Add to dashboard Cite

Objective. To perform a state-of-the-art review of the literature from January 2012 through May 2015 on studies that advanced our knowledge of the innate and adaptive immunology related to otitis media. This review also proposes future directions for research in this area.Data Sources. PubMed database of the National Library of Medicine.Review Methods. Three subpanels comprising experts in the field focused on sections relevant to cytokines, innate immunity, and adaptive immunity. The review focused on animal, cell line, and human studies and was critical in relation to the recommendations from the previous publication and for determination of the proposed goals and priorities. The panel met at the 18th International Symposium on Recent Advances in Otitis Media in June 2015 to consolidate its prior search results and discuss, plan, and refine the review. The panel approved the final draft.Conclusion. From 2012 to 2014, tremendous progresses in immunology of otitis media were established-especially in the areas of innate immunity associated with the pathogenesis of otitis media.Implications for Practice. The advances of the past 4 years formed the basis for a series of short-and long-term research goals in an effort to guide the field. Accomplishing these goals will provide opportunities for the development of novel interventions, including new ways to better treat and prevent otitis media, especially for recurrent otitis media.

show abstract

“…A significantly lower percentage of CD31CD691, CD41CD691, CD81CD691, and CD191CD691 cells was found in the adenoids in patients with OME, attesting to reduced T-cell activation. 113 The percentages of apoptotic lymphocytes and CD41, CD81, and CD191 cells with CD951 antigen and Bcl-2 protein in the adenoid tissue were examined by Zelazowska-Rutkowska et al 114 The percentages of CD41Bcl-21, CD81Bcl-21, and CD191Bcl-21 lymphocytes were lower in OM patients, whereas the percentages of CD41, CD81, and CD191 cells with CD951 antigen were higher. The tendency of reduced percentages of T and B lymphocytes with Bcl-2 expression (inhibits apoptosis) and elevated percentages of these cells with CD951 expression may reflect local immunity disorders.…”

Section: Cell Biologymentioning

confidence: 99%