Dendritic Cell Maturation Controls Adhesion, Synapse Formation, and the Duration of the Interactions with Naive T Lymphocytes

Benvenuti, Federica; Lagaudrière-Gesbert, Cécile; Grandjean, Isabelle; Jancic, Carolina; Hivroz, Claire; Trautmann, Alain; Lantz, Olivier; Amigorena, Sebastián

doi:10.4049/jimmunol.172.1.292

Cited by 130 publications

(126 citation statements)

References 44 publications

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“…As maturation, DCs lose their endocytic ability, up-regulate MHC class II and costimulatory molecules, and present antigen to T cells for the initiation of immune responses [11]. DCs influence T cell proliferation and effector function by providing costimulation and establishing the cytokine environment at the time of T cell priming [12,13].…”

Section: Discussionmentioning

confidence: 99%

“…In addition, the direction of T cells polarization determined the prognosis of many infectious diseases and cancers. In cancer patients with high expression of the Th1 cells had a prolonged disease-free survival [10], while with high expression of the Th2 cells, the patients had a poor progressive [11]. It was reported that Th1 immunity was compromised in infections, while enhancing Th1 responses improved the anti-inflammatory effect [12,13].…”

Section: Introductionmentioning

confidence: 99%

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The Pseudomonas aeruginosa Mannose Sensitive Hamemagglutination Strain (PA-MSHA) Induces a Th1-Polarizing Phenotype by Promoting Human Dendritic Cells Maturation

Zhang

Wang

Li³

et al. 2013

Indian J Microbiol

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Pseudomonas aeruginosa mannose sensitive hamemagglutination strain (PA-MSHA) is a kind of peritrichous P. aeruginosa strain with MSHA fimbriae and has been shown to activate kinds of immunocytes. Dendritic cells (DCs) are specialized antigen-presenting cells required for the stimulating and priming CD4? T cells toward the T helper cell type 1 (Th1), Th2 and other different phenotypes. PA-MSHA effecting on Th1 remains an important missing link. Here we demonstrated that PA-MSHA augmented monocytes derived-dendritic cells (Mo-DCs) expression of HLA-DR, co-stimulatory and adhesion molecules, and induced Th1-promoting interleukin-12 and tumor necrosis factor a secretion, in addition, PA-MSHA treated MoDCs displayed lesser endocytic capacity. Furthermore, in mixed lymphocyte reactions, allostimulatory capacity of Mo-DCs was enhanced by PA-MSHA, CD4? T cells stimulated by PA-MSHA -activated Mo-DCs showed a Th1-polarized cytokine production, increasing secretion of IFN-c and decreasing secretion of IL-10 and IL-4. Our findings identified PA-MSHA as an important exogenous factor that induced DCs maturation toward a Th1-promoting phenotype.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Pseudomonas aeruginosa Mannose Sensitive Hamemagglutination Strain (PA-MSHA) Induces a Th1-Polarizing Phenotype by Promoting Human Dendritic Cells Maturation

Zhang

Wang

Li³

et al. 2013

Indian J Microbiol

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“…The activation status of dendritic cells (DCs) is a critical determinant of the outcome of Ag recognition by T cells (11,12). Ag presentation by immature DCs often results in tolerance, whereas mature DCs are associated with the priming of T cell populations (11,13,14).…”

Section: Ifferent Subsets Of Effector Cd4mentioning

confidence: 99%

Differential Requirements for Th1 and Th17 Responses to a Systemic Self-Antigen

Katzman

Gallo

Hoyer

et al. 2011

The Journal of Immunology

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T cell–APC interactions are essential for the initiation of effector responses against foreign and self-antigens, but the role of these interactions in generating different populations of effector T cells in vivo remains unclear. Using a model of CD4+ T cell responses to a systemic self-antigen without adjuvants or infection, we demonstrate that activation of APCs augments Th17 responses much more than Th1 responses. Recognition of systemic Ag induces tolerance in self-reactive CD4+ T cells, but induction of CD40 signaling, even under tolerogenic conditions, results in a strong, Ag-specific IL-17 response without large numbers of IFN-γ–producing cells. Transfer of the same CD4+ T cells into lymphopenic recipients expressing the self-antigen results in uncontrolled production of IL-17, IFN-γ, and systemic inflammation. If the Ag-specific T cells lack CD40L, production of IL-17 but not IFN-γ is decreased, and the survival time of recipient mice is significantly increased. In addition, transient blockade of the initial MHC class II-dependent T cell–APC interaction results in a greater reduction of IL-17 than of IFN-γ production. These data suggest that Th17 differentiation is more sensitive to T cell interactions with APCs than is the Th1 response, and interrupting this interaction, specifically the CD40 pathway, may be key to controlling Th17-mediated autoimmunity.

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“…It was not surprising to find that tumor-treated DCs could achieve less DCs-dependent T cell proliferation and antigen-specific CTL priming. As IL-12 is one of the key mediators of signal 3 to promote Th1-cell or CTL development (33), the decrements of IL-12 secretion and effectors CTL priming in our data might indicate that tumor cells-incubated DCs failed to induce the differentiation of T cells with full function (34).…”

Section: Discussionmentioning

confidence: 68%

Dysfunction of Murine Dendritic Cells Induced by Incubation with Tumor Cells

Gao

Xin

et al. 2008

Cell Mol Immunol

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In vivo studies showed that dendritic cell (DC) dysfunction occurred in tumor microenvironment. As tumors were composed of many kinds of cells, the direct effects of tumor cells on immature DCs (imDCs) are needed for further studies in vitro. In the present study, bone marrow-derived imDCs were incubated with lymphoma, hepatoma and menaloma cells in vitro and surface molecules in imDCs were determined by flow cytometry. Then, imDCs incubated with tumor cells or control imDCs were further pulsed with tumor lysates and then incubated with splenocytes to perform mixed lymphocyte reaction. The DC-dependent tumor antigen-specific T cell proliferation, and IL-12 secretion were determined by flow cytometry, and enzyme-linked immunosorbent assay respectively.

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Dendritic Cell Maturation Controls Adhesion, Synapse Formation, and the Duration of the Interactions with Naive T Lymphocytes

Cited by 130 publications

References 44 publications

The Pseudomonas aeruginosa Mannose Sensitive Hamemagglutination Strain (PA-MSHA) Induces a Th1-Polarizing Phenotype by Promoting Human Dendritic Cells Maturation

The Pseudomonas aeruginosa Mannose Sensitive Hamemagglutination Strain (PA-MSHA) Induces a Th1-Polarizing Phenotype by Promoting Human Dendritic Cells Maturation

Differential Requirements for Th1 and Th17 Responses to a Systemic Self-Antigen

Dysfunction of Murine Dendritic Cells Induced by Incubation with Tumor Cells

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