Dendrimers in Oncology: An Expanding Horizon

Tekade, Rakesh K.; Kumar, Palanirajan Vijayaraj; Jain, Narendra Kumar

doi:10.1021/cr900113j

Cited by 39 publications

(46 citation statements)

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“…Since the first reports of well-characterized dendrimers in 1985 (refs 16-19), thousands of research articles addressed their synthesis, properties and applications [1][2][3][4][5][6][7][8][9][20][21][22][23] . Recent activity in this area reflects a growing interest in biomedical applications such as bio-imaging, gene and drug delivery [24][25][26][27][28] . The overwhelming majority of the literature concerns the go og max range and highlights structural perfection.…”

mentioning

confidence: 99%

Synthetic regimes due to packing constraints in dendritic molecules confirmed by labelling experiments

Zhang

Schlüter

et al. 2013

Nat Commun

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Classical theory predicts that branching defects are unavoidable in large dendritic molecules when steric congestion is important. Here we report first experimental evidence of this effect via labelling measurements of an extended homologous series of generations g ¼ 1y6 of dendronized polymers. This system exhibits a single type of defect interrogated specifically by the Sanger reagent thus permitting to identify the predicted upturn in the number of branching defects when g approaches g max and the polymer density approaches close packing. The average number of junctions and defects for each member of the series is recursively obtained from the measured molar concentrations of bound labels and the mass concentrations of the dendritic molecules. The number of defects increases at g ¼ 5 and becomes significant at g ¼ 6 for dendronized polymers where the g max was estimated to occur at 6.1 rg max r 7.1. The combination of labelling measurements with the novel theoretical analysis affords a method for characterizing high g dendritic systems.

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mentioning

confidence: 99%

Synthetic regimes due to packing constraints in dendritic molecules confirmed by labelling experiments

Zhang

Schlüter

et al. 2013

Nat Commun

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“…A modulatory liposomal controlled release system (MLCRS) combined liposomal and dendrimeric technologies incorporating the anticancer drug doxorubicin has been recently reported (Papagiannaros et al, 2005) while dendrimers locked-into liposomal formulation (D locked-in L) is a new term in the drug delivery (Tekade et al, 2009;Gardikis et al, 2010a) and considered as a class of MLCRSs. We followed the concept of using acronyms, in order to reach to a specific description of modulatory controlled release nanosystems (MCRnSs).…”

Section: Advanced Drug Delivery Nanosystems and A Proposal To Their Cmentioning

confidence: 99%

Advanced drug delivery nanosystems (aDDnSs): a mini-review

Demetzos¹,

Pippa²

2013

Drug Delivery

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Significant progress has been made in nanoscale drugs and delivery systems employing diverse chemical formulations to facilitate the rate of drug delivery and to improve its pharmacokinetics. Biocompatible nanomaterials have been used as biological markers, contrast agents for imaging, healthcare products, pharmaceuticals, drug-delivery systems as well as in detection, diagnosis and treatment of various types of diseases. The classification of drug delivery nanosystems (DDnSs) is a crucial issue and fundamental efforts on this subject are missing from the literature. This article deals with the classification of DDnSs with a modulatory controlled release profile (MCR) denoted as modulatory controlled release nanosystems (MCRnSs). Conventional (c) and advanced (a) DDnSs are denoted by the acronyms cDDnSs and aDDnSs, and can be composed of a single or more than one biomaterials, respectively. The classification was based on their characteristics such as: surface functionality (f), the nature of biomaterials used and the kind of interactions between biomaterials. The aDDnSs can be classified as hybridic (Hy-) or chimeric (Chi-) based on the nature -same or different respectively -of biomaterials and inorganic materials used. The nature of the elements used for producing advanced biomaterials is of great importance and medicinal chemistry contributes effectively to the production of aDDnSs.

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“…The increasing branch density with generation is believed to have striking effects on the structure of dendrimers which are characterized by the presence of internal cavities to encapsulate a large number of reactive guest molecules. In recent years, in order to increase their targeting transfection efficiency, interactions of dendrimers with lipid bilayers, DNA and other molecules have been explored using theoretical and computational modeling methods (18)(19)(20). Hence, PAMAM dendrimers with high transfection efficiencies and minimal cytotoxicity may be effective in gene transfer and may have appropriate applications in various fields of biology and medicine.…”

Section: Characteristics Of Pamam Dendrimersmentioning

confidence: 99%

Polyamidoamine dendrimers as gene delivery carriers in the inner ear: How to improve transfection efficiency

Wang

Shi

Yin

2011

Experimental and Therapeutic Medicine

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Abstract. Hair cells in the cochlea can be damaged by various insults, including noise, drugs, infections and presbycusis, which may cause sensorineural hearing loss. Gene therapy is a novel therapeutic technology that, recently, has led to the idea of treating inner ear diseases on a genetic level. Depending on their characteristics, such as a high efficiency in delivery, the capability of specific targeting, multifunctionality, biodegradability, non-toxicity, non-immunogenicity and the capability of limiting DNA degradation, nanovectors, such as polyamidoamine (PAMAM) dendrimers for cellular gene delivery, provide a promising approach to eradicate genetic diseases. They are a new class of highly branched spherical polymers that are highly soluble in aqueous solution. Their unique surface is composed of positively charged primary amine groups which allow them to form stable complexes with plasmid DNA, oligonucleotides, antibodies and drugs. This review provides an overview of the characteristics of PAMAMs which may be used in gene transfer into the cochlea as well as the efforts to improve their transfection efficiency as gene-delivery carriers.

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Dendrimers in Oncology: An Expanding Horizon

Cited by 39 publications

References 0 publications

Synthetic regimes due to packing constraints in dendritic molecules confirmed by labelling experiments

Synthetic regimes due to packing constraints in dendritic molecules confirmed by labelling experiments

Advanced drug delivery nanosystems (aDDnSs): a mini-review

Polyamidoamine dendrimers as gene delivery carriers in the inner ear: How to improve transfection efficiency

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