Dendrimers in gene delivery

Bharti, Divya; Pooja, Deep; Kulhari, Hitesh

doi:10.1016/b978-0-12-814527-2.00009-3

Cited by 14 publications

(12 citation statements)

References 115 publications

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“…For example, dendrimers, such as polyamide amine (PAMAM), protect the agent from damage and the net positive charge of dendrimers–agent complex determines the transfection efficiency. 54 …”

Section: Binding Modes Of Rvg Peptides and Carriers For Treating Cns ...mentioning

confidence: 99%

Application progress of RVG peptides to facilitate the delivery of therapeutic agents into the central nervous system

et al. 2021

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Section: Binding Modes Of Rvg Peptides and Carriers For Treating Cns ...mentioning

confidence: 99%

Application progress of RVG peptides to facilitate the delivery of therapeutic agents into the central nervous system

et al. 2021

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“…With the onset of this kind of therapy, new approaches have been made for therapeutic purposes and they are much more effective than conventional strategies for treating cancers, genetic diseases, including cystic fibrosis, and other diseases, such as cardiovascular and nervous diseases and complex autoimmune diseases. In addition, the gene therapy approach can also be used for the treatment of acquired diseases or polygenic ones, by increasing the immune response using complex gene delivery strategies, releasing suicide genes that trigger cell apoptosis [ 12 , 13 , 14 , 15 ]. Additionally, gene therapy is increasingly being addressed in the fundamental research and in bio-nanotechnology to investigate the basic cellular mechanisms or obtain specific proteins [ 16 , 17 , 18 ].…”

Section: Gdept Strategymentioning

confidence: 99%

“…Through the dendritic ramifications, these complexes ensure the protection of NA from enzymatic degradation and, moreover, different dendrimers containing numerous tertiary amine groups show the “proton sponge” effect, which protects complexes from the action of lysosomes, endosomal and nuclear gene degradation [ 13 , 160 ].…”

Section: Dendrimers In Gdept Strategymentioning

confidence: 99%

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Dendrimers as Non-Viral Vectors in Gene-Directed Enzyme Prodrug Therapy

et al. 2021

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Gene-directed enzyme prodrug therapy (GDEPT) has been intensively studied as a promising new strategy of prodrug delivery, with its main advantages being represented by an enhanced efficacy and a reduced off-target toxicity of the active drug. In recent years, numerous therapeutic systems based on GDEPT strategy have entered clinical trials. In order to deliver the desired gene at a specific site of action, this therapeutic approach uses vectors divided in two major categories, viral vectors and non-viral vectors, with the latter being represented by chemical delivery agents. There is considerable interest in the development of non-viral vectors due to their decreased immunogenicity, higher specificity, ease of synthesis and greater flexibility for subsequent modulations. Dendrimers used as delivery vehicles offer many advantages, such as: nanoscale size, precise molecular weight, increased solubility, high load capacity, high bioavailability and low immunogenicity. The aim of the present work was to provide a comprehensive overview of the recent advances regarding the use of dendrimers as non-viral carriers in the GDEPT therapy.

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“…A dendrimer generation is referred to monomeric branches that are added to the core during the synthesis [ 15 ]. With increasing generation, dendritic macromolecules typically expand in size and take on a more globular form, thereby offering large void spaces for encapsulation [ 16 ]. Hydrogen bonds, chemical linkages, or hydrophobic interactions can be involved in loading drugs into dendrimer core cavities and conjugate targeting ligands onto the surface endings [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Dendrimer-Mediated Delivery of Anticancer Drugs for Colon Cancer Treatment

et al. 2023

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The third most common cancer worldwide is colon cancer (CC). Every year, there more cases are reported, yet there are not enough effective treatments. This emphasizes the need for new drug delivery strategies to increase the success rate and reduce side effects. Recently, a lot of trials have been done for developing natural and synthetic medicines for CC, among which the nanoparticle-based approach is the most trending. Dendrimers are one of the most utilized nanomaterials that are accessible and offer several benefits in the chemotherapy-based treatment of CC by improving the stability, solubility, and bioavailability of drugs. They are highly branched polymers, making it simple to conjugate and encapsulate medicines. Dendrimers have nanoscale features that enable the differentiation of inherent metabolic disparities between cancer cells and healthy cells, enabling the passive targeting of CC. Moreover, dendrimer surfaces can be easily functionalized to improve the specificity and enable active targeting of colon cancer. Therefore, dendrimers can be explored as smart nanocarriers for CC chemotherapy.

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Dendrimers in gene delivery

Cited by 14 publications

References 115 publications

Application progress of RVG peptides to facilitate the delivery of therapeutic agents into the central nervous system

Application progress of RVG peptides to facilitate the delivery of therapeutic agents into the central nervous system

Dendrimers as Non-Viral Vectors in Gene-Directed Enzyme Prodrug Therapy

Dendrimer-Mediated Delivery of Anticancer Drugs for Colon Cancer Treatment

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