Dendrimers for gene therapy

Santander-Ortega, Manuel J.; Lozano, M.; Uchegbu, Ijeoma F.; Schätzlein, Andreas

doi:10.1016/b978-0-08-100520-0.00006-0

Cited by 4 publications

(2 citation statements)

References 214 publications

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“…Hydrogels, on the other hand, are composed of hydrophilic crosslinked polymer chains capable of cargo entrapment and delivery [ 63 , 64 , 65 ]. Dendrimers and hydrogels have been reported for the efficient delivery of genes, drugs, and proteins [ 66 , 67 , 68 , 69 , 70 , 71 ] and for stimulus-responsive release under various triggers, including temperature, pH, and redox conditions [ 72 , 73 ]. However, dendrimers suffer from their complicated and costly synthesis procedures, and both dendrimers and hydrogels are restricted by their ability to host solely hydrophilic drugs [ 60 ]; Lipid-based nanocarriers include liposomes and micelles.…”

Section: Smart Drug Delivery Nanocarriersmentioning

confidence: 99%

Gold-Nanoparticle Hybrid Nanostructures for Multimodal Cancer Therapy

et al. 2022

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With the urgent need for bio-nanomaterials to improve the currently available cancer treatments, gold nanoparticle (GNP) hybrid nanostructures are rapidly rising as promising multimodal candidates for cancer therapy. Gold nanoparticles (GNPs) have been hybridized with several nanocarriers, including liposomes and polymers, to achieve chemotherapy, photothermal therapy, radiotherapy, and imaging using a single composite. The GNP nanohybrids used for targeted chemotherapy can be designed to respond to external stimuli such as heat or internal stimuli such as intratumoral pH. Despite their promise for multimodal cancer therapy, there are currently no reviews summarizing the current status of GNP nanohybrid use for cancer theragnostics. Therefore, this review fulfills this gap in the literature by providing a critical analysis of the data available on the use of GNP nanohybrids for cancer treatment with a specific focus on synergistic approaches (i.e., triggered drug release, photothermal therapy, and radiotherapy). It also highlights some of the challenges that hinder the clinical translation of GNP hybrid nanostructures from bench to bedside. Future studies that could expedite the clinical progress of GNPs, as well as the future possibility of improving GNP nanohybrids for cancer theragnostics, are also summarized.

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Section: Smart Drug Delivery Nanocarriersmentioning

confidence: 99%

Gold-Nanoparticle Hybrid Nanostructures for Multimodal Cancer Therapy

et al. 2022

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“…There are a number of nanocarriers used for gene delivery ( Figure 25 ) [ 489 ] applications which are based on lipids [ 490 , 491 ], liposomes [ 492 , 493 , 494 ], dendrimers [ 495 ], polymers [ 496 , 497 ], graphene [ 498 , 499 ], carbon nanotubes (CNTs) [ 500 , 501 ], mesoporous silica [ 502 ], gold nanoparticles [ 503 , 504 ], magnetic nanoparticles [ 505 , 506 ], and other types of inorganic nanoparticles.…”

Section: Applications Of Nanobiomaterialsmentioning

confidence: 99%

Comprehensive Survey on Nanobiomaterials for Bone Tissue Engineering Applications

et al. 2020

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One of the most important ideas ever produced by the application of materials science to the medical field is the notion of biomaterials. The nanostructured biomaterials play a crucial role in the development of new treatment strategies including not only the replacement of tissues and organs, but also repair and regeneration. They are designed to interact with damaged or injured tissues to induce regeneration, or as a forest for the production of laboratory tissues, so they must be micro-environmentally sensitive. The existing materials have many limitations, including impaired cell attachment, proliferation, and toxicity. Nanotechnology may open new avenues to bone tissue engineering by forming new assemblies similar in size and shape to the existing hierarchical bone structure. Organic and inorganic nanobiomaterials are increasingly used for bone tissue engineering applications because they may allow to overcome some of the current restrictions entailed by bone regeneration methods. This review covers the applications of different organic and inorganic nanobiomaterials in the field of hard tissue engineering.

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