Dendrimers bearing three types of branching functions

Salamończyk, Grzegorz M.; Kuźnikowski, Maciej; Poniatowska, Elżbieta

doi:10.1016/s0040-4039(02)00088-6

Cited by 21 publications

(12 citation statements)

References 12 publications

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“…20 The trimethylsilane modification made 6 to be much less reactive than 1, thus 50 equiv. This reagent has been successfully applied by Salamończyk for selective oxidation of phosphite groups in dendrimers already possessing diester P = S and P = Se branching units within the same molecule.…”

Section: Resultsmentioning

confidence: 99%

Synthesis of PS/PO-chimeric oligonucleotides using mixed oxathiaphospholane and phosphoramidite chemistry

Radzikowska

Baraniak

2015

Org. Biomol. Chem.

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Chimeric oligonucleotides containing phosphodiester and phosphorothioate linkages have been obtained using the solid phase synthesis. The oligonucleotide parts possessing natural internucleotide phosphate bonds were assembled using commercially available nucleoside 3'-O-(2-cyanoethyl-N,N-diisopropylamino)phosphoramidites 7 whereas the phosphorothioate segment was built using nucleoside 3'-O-(2-thio-1,3,2-oxathiaphospholanes) 3. The oxidation steps, crucial for the conversion of phosphite linkages into the phosphate moieties, were conducted using tert-butylperoxy-trimethylsilane, and this reagent was not harmful to the diester phosphorothioate linkages. When P-diastereopure nucleoside 3'-O-(2-thio-1,3,2-oxathiaphospholane) monomers were employed the resulting chimeric backbone retained the P-stereoregularity of the phosphorothioate units.

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Section: Resultsmentioning

confidence: 99%

Synthesis of PS/PO-chimeric oligonucleotides using mixed oxathiaphospholane and phosphoramidite chemistry

Radzikowska

Baraniak

2015

Org. Biomol. Chem.

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“…The repetition of both steps was carried out up to the fi fth generation. It is even possible to build dendrimers possessing a different type of phosphate at each generation, chosen between P = S, P = Se, and P = O, affording layered dendrimers 39 (Figure 1.21 ).…”

Section: Syntheses Of Phosphorus -Containing Dendrimersmentioning

confidence: 99%

Syntheses of Dendrimers and Dendrons

Caminade

2011

Dendrimers

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“…The repetition of both steps was carried out up to the fifth generation 6-G 5 . The same type of method is also usable for the synthesis of dendrimers possessing selenium, oxygen [14] or boron hydride [15] instead of sulfur linked to phosphorus. It is even possible to build original dendrimers possessing a different type of phosphate at each generation, chosen between P=S, P=Se, and P=O, affording layered dendrimers [16] …”

Section: Aibnmentioning

confidence: 99%

“…Another example of non fully symmetrical dendritic species possessing only one type of end groups is provided by the third generation dendron 46-G 3 possessing phosphines both at the level of the core (2) and as end groups (16). The Staudinger reaction of this species with 18 equivalents of dendron 47-G 4 possessing an azide as core affords the complex dendritic species 48.…”

Section: -G 3 Gmentioning

confidence: 99%

Synthetic Pathways Towards Phosphorus Dendrimers and Dendritic Architectures

Caminade¹,

Turrin²,

Laurent³

et al. 2006

COC

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The methods of synthesis of dendrimers and dendritic macromolecules possessing phosphorus derivatives at each branching points are reviewed. Classical methods using the repetition of two steps are first described, then various ways usable to shorten the time needed for the synthesis are emphasized. These improvements include the use of accelerated methods (one step for one generation), and of dendrons (dendritic wedges) to increase rapidly the number of generations. Beside classical dendrimers constituted by only one type of branches and one type of functional end groups, more sophisticated dendritic structures are described. In particular, up to 4 types of functional end groups can be grafted to each divergent point of the surface, or two types of functional groups can be located at the end of particular branches of special dendritic species. In the latter case, the dendritic species are obtained either by reacting functional groups included at particular layers of a main dendrimer, or taking advantage of the reactivity of the function located at the core of dendrons.

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Dendrimers bearing three types of branching functions

Cited by 21 publications

References 12 publications

Synthesis of PS/PO-chimeric oligonucleotides using mixed oxathiaphospholane and phosphoramidite chemistry

Synthesis of PS/PO-chimeric oligonucleotides using mixed oxathiaphospholane and phosphoramidite chemistry

Syntheses of Dendrimers and Dendrons

Synthetic Pathways Towards Phosphorus Dendrimers and Dendritic Architectures

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