Syntheses of Dendrimers and Dendrons

Caminade, Anne‐Marie

doi:10.1002/9781119976530.ch1

Cited by 4 publications

(1 citation statement)

References 69 publications

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“…The next step is the deprotection or activation of this first generation (G1) to react with other branched monomers in order to couple the second generation (G2), and so on. When a new layer of branching units is created, a new generation is obtained, i.e., the number of the generation corresponds to the number of branched layers from the core [54]. In the divergent method, it is important that every step of the reaction is fully completed before the addition of a new generation so as to avoid deficiently formed branches [11].…”

Section: Divergent Growth Methodsmentioning

confidence: 99%

Dendrimers as Pharmaceutical Excipients: Synthesis, Properties, Toxicity and Biomedical Applications

2019

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The European Medicines Agency (EMA) and the Current Good Manufacturing Practices (cGMP) in the United States of America, define excipient as the constituents of the pharmaceutical form other than the active ingredient, i.e., any component that is intended to furnish pharmacological activity. Although dendrimers do not have a pharmacopoeia monograph and, therefore, cannot be recognized as a pharmaceutical excipient, these nanostructures have received enormous attention from researchers. Due to their unique properties, like the nanoscale uniform size, a high degree of branching, polyvalency, aqueous solubility, internal cavities, and biocompatibility, dendrimers are ideal as active excipients, enhancing the solubility of poorly water-soluble drugs. The fact that the dendrimer’s properties are controllable during their synthesis render them promising agents for drug-delivery applications in several pharmaceutical formulations. Additionally, dendrimers can be used for reducing the drug toxicity and for the enhancement of the drug efficacy. This review aims to discuss the properties that turn dendrimers into pharmaceutical excipients and their potential applications in the pharmaceutical and biomedical fields.

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Section: Divergent Growth Methodsmentioning

confidence: 99%