Dendrimers as nanoscale vectors: Unlocking the bars of cancer therapy

Dey, Asmita Deka; Bigham, Ashkan; Esmaeili, Yasaman; Ashrafizadeh, Milad; Moghaddam, Farnaz Dabbagh; Tan, Shing Cheng; Yousefiasl, Satar; Sharma, Saurav; Maleki, Aziz; Rabiee, Navid; Kumar, Alan Prem; Thakur, Vijay Kumar; Orive, Gorka; Sharifi, Esmaeel; Kumar, Arun; Makvandi, Pooyan

doi:10.1016/j.semcancer.2022.06.003

Cited by 28 publications

(9 citation statements)

References 210 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Therefore, dendrimers containing these surface functional molecules cannot bind nucleic acids. The dendrimers and nucleic acids that form on amine-terminated dendrimers can exhibit considerable variation in size and structure due to the multiple charges in both ( Dey et al, 2022 ). In addition to individual characterizing dendrimers (generations), the sizes are affected by the nucleic acid, the N/P ratio (also known as the charge ratio) between dendrimers and nucleic acids and the solvent properties (Sahu et al, 2023).…”

Section: Application Of Dendrimers As Drug Delivery Systems For the B...mentioning

confidence: 99%

Dendrimer: An update on recent developments and future opportunities for the brain tumors diagnosis and treatment

et al. 2023

View full text Add to dashboard Cite

A brain tumor is an uncontrolled cell proliferation, a mass of tissue composed of cells that grow and divide abnormally and appear to be uncontrollable by the processes that normally control normal cells. Approximately 25,690 primary malignant brain tumors are discovered each year, 70% of which originate in glial cells. It has been observed that the blood-brain barrier (BBB) limits the distribution of drugs into the tumour environment, which complicates the oncological therapy of malignant brain tumours. Numerous studies have found that nanocarriers have demonstrated significant therapeutic efficacy in brain diseases. This review, based on a non-systematic search of the existing literature, provides an update on the existing knowledge of the types of dendrimers, synthesis methods, and mechanisms of action in relation to brain tumours. It also discusses the use of dendrimers in the diagnosis and treatment of brain tumours and the future possibilities of dendrimers. Dendrimers are of particular interest in the diagnosis and treatment of brain tumours because they can transport biochemical agents across the BBB to the tumour and into the brain after systemic administration. Dendrimers are being used to develop novel therapeutics such as prolonged release of drugs, immunotherapy, and antineoplastic effects. The use of PAMAM, PPI, PLL and surface engineered dendrimers has proven revolutionary in the effective diagnosis and treatment of brain tumours.

show abstract

Section: Application Of Dendrimers As Drug Delivery Systems For the B...mentioning

confidence: 99%

Dendrimer: An update on recent developments and future opportunities for the brain tumors diagnosis and treatment

et al. 2023

View full text Add to dashboard Cite

show abstract

“…4) are a specic type of polymeric nanoparticles featuring a multi-branched 3D structure and modied by multifunctional groups on the surface, which permit to encapsulate or conjugating anti-tumor drug on the surface or in the core, thus signicantly improving their functionality and making them versatile. [77][78][79] Dendrimers are composed of a central core covalently linked by branches of highly repeating units and terminal chemical structures that congure the surface of the dendrimers. 80 Controlled drug release is achieved by the outer functional groups with modications that are triggered by a certain pH or specic enzymes.…”

Section: Polymer Micelles (Pms)mentioning

confidence: 99%

New insights into nanosystems for non-small-cell lung cancer: diagnosis and treatment

et al. 2023

View full text Add to dashboard Cite

show abstract

“…Because of these characteristics, as well as their inherent biocompatibility, viruses have been developed as actively targeted delivery platforms, which can improve recent drug de-livery methods. [98,99] In the current section, different nanostructures based on genetically engineered viruses and their application in drug delivery will be reviewed.…”

Section: Nanoscale Genetically Engineered Viral Platformsmentioning

confidence: 99%

“…To overcome these inadequacies, various organisms and nanocarriers have been developed. [1,2] Nanotechnology has introduced operative nanoplatforms in drug delivery systems that have led to various progressive materials for the safe delivery and release of a wide variety of therapeutic agents into targeted sites. [3] As a result, an ordered structure must be developed that could allow for a continuous release of the drug while overcoming firstpass metabolism and pharmacological adverse effects.…”

Section: Introductionmentioning

confidence: 99%

Genetically Engineered Viral Vectors and Organic‐Based Non‐Viral Nanocarriers for Drug Delivery Applications

Hajebi

Yousefiasl

Rahimmanesh

et al. 2022

Adv Healthcare Materials

Self Cite

View full text Add to dashboard Cite

Conventional drug delivery systems are challenged by concerns related to systemic toxicity, repetitive doses, drug concentrations fluctuation, and adverse effects. Various drug delivery systems are developed to overcome these limitations. Nanomaterials are employed in a variety of biomedical applications such as therapeutics delivery, cancer therapy, and tissue engineering. Physiochemical nanoparticle assembly techniques involve the application of solvents and potentially harmful chemicals, commonly at high temperatures. Genetically engineered organisms have the potential to be used as promising candidates for greener, efficient, and more adaptable platforms for the synthesis and assembly of nanomaterials. Genetically engineered carriers are precisely designed and constructed in shape and size, enabling precise control over drug attachment sites. The high accuracy of these novel advanced materials, biocompatibility, and stimuli‐responsiveness, elucidate their emerging application in controlled drug delivery. The current article represents the research progress in developing various genetically engineered carriers. Organic‐based nanoparticles including cellulose, collagen, silk‐like polymers, elastin‐like protein, silk‐elastin‐like protein, and inorganic‐based nanoparticles are discussed in detail. Afterward, viral‐based carriers are classified, and their potential for targeted therapeutics delivery is highlighted. Finally, the challenges and prospects of these delivery systems are concluded.

show abstract

Dendrimers as nanoscale vectors: Unlocking the bars of cancer therapy

Cited by 28 publications

References 210 publications

Dendrimer: An update on recent developments and future opportunities for the brain tumors diagnosis and treatment

Dendrimer: An update on recent developments and future opportunities for the brain tumors diagnosis and treatment

New insights into nanosystems for non-small-cell lung cancer: diagnosis and treatment

Genetically Engineered Viral Vectors and Organic‐Based Non‐Viral Nanocarriers for Drug Delivery Applications

Contact Info

Product

Resources

About