Dendrimers and Hyperbranched Polymers for Drug Delivery

Kannan, Rangaramanujam M.; Perumal, Omathanu; Kannan, Sujatha

doi:10.1002/9780470152928.ch5

Cited by 17 publications

(23 citation statements)

References 56 publications

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“…In summary, multiple studies have shown that a large number of factors affecting PAMAM cellular uptake and trafficking and conflicting conclusions exist regarding different pathways and the subsequent cytotoxic response [70]. It is thus important to understand the underpinning interactions between the dendrimers and cellular membranes.…”

Section: Cytotoxicity Of Pamam Dendrimersmentioning

confidence: 99%

PAMAM dendrimer - cell membrane interactions

Fox

Richardson

Briscoe

2018

Advances in Colloid and Interface Science

182

135

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General rightsThis document is made available in accordance with publisher policies. Please cite only the published version using the reference above. 2018 PAMAM dendrimers have been conjectured for a wide range of biomedical applications due to their tuneable physicochemical properties. However, their application has been hindered by uncertainties in their cytotoxicity, which is influenced by dendrimer generation (i.e. size and surface group density), surface chemistry, and dosage, as well as cell specificity. In this review, biomedical applications of polyamidoamine (PAMAM) dendrimers and some related cytotoxicity studies are first outlined. Alongside these in vitro experiments, lipid membranes such as supported lipid bilayers (SLBs), liposomes, and Langmuir monolayers have been used as cell membrane models to study PAMAM dendrimer-membrane interactions. Related experimental and theoretical studies are summarized, and the physical insights from these studies are discussed to shed light on the fundamental understanding of PAMAM dendrimer-cell membrane interactions. We conclude with a summary of some questions that call for further investigations.a b s t r a c t a r t i c l e i n f o Available online 27 June

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Section: Cytotoxicity Of Pamam Dendrimersmentioning

confidence: 99%

PAMAM dendrimer - cell membrane interactions

Fox

Richardson

Briscoe

2018

Advances in Colloid and Interface Science

182

135

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show abstract

“…They are characterized by a central core and multiple functionalities at the periphery. The surface functionality can be 'tailored' to attach a variety of drugs, genes, targeting agents and imaging agents either by complexation or conjugation [3]. Dendritic polymers have been demonstrated to produce high intracellular drug levels [4][5][6][7].…”

Section: Introductionmentioning

confidence: 99%

“…As drug delivery vehicles, dendrimers offer distinct advantages of monodispersity and multivalency [3][4][5]. They are characterized by a central core and multiple functionalities at the periphery.…”

Section: Introductionmentioning

confidence: 99%

The effect of surface functionality on cellular trafficking of dendrimers

Perumal¹,

Inapagolla²,

Kannan³

et al. 2008

Biomaterials

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344

276

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“…To this end, a handful of reports describing the application of highly branched molecules termed ''dendrimers'' have been reported in the literature. Dendrimers possess a range of attractive features such as multi-valency, nano-size, spherical architecture, surface-functional groups, low polydispersity and precise molecular weight, all of which render them versatile vectors in drug delivery (El-Sayed et al, 2002; Kannan et al, 2005;Vandamme & Brobeck 2005;Bai & Ahsan, 2009;Menjoge et al, 2010). Of the few reports available on the application of dendrimers for skin-mediated delivery of therapeutics, poly(amidoamine) (PAMAM) dendrimers have been among the most widely reported.…”

Section: Introductionmentioning

confidence: 99%

Enhancement in deposition and permeation of 5-fluorouracil through human epidermis assisted by peptide dendrimers

et al. 2013

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Enhancing the deposition and permeation of 5-fluorouracil across human epidermis assisted by appropriately charged and well-defined peptide dendrimers was investigated. Peptide dendrimers with arginine as the terminal amino acid and having a range of terminal positive charges (4þ and 16 þ ) were synthesized by solid phase peptide synthesis. Various parameters including effect of peptide dendrimers on the solubility and partition coefficient of 5-FU, degradation of drug in skin as well as deposition and permeation of 5-FU in/through skin were studied. All the tested dendrimers increased the aqueous solubility and partition coefficient of 5-FU with each also significantly (p50.05) enhancing the deposition and permeation of 5-FU in/across human epidermis in a concentration-dependent manner. Of the three peptide dendrimers examined, R8 dendrimer (bearing 8 þ charge derived from four terminal arginines and MW of &1000 Da) showed greatest values for flux, Q 48 (cumulative amount of drug permeated at the end of 48 h) and amount of drug retained in human skin. Furthermore, this study also scrutinized and reports on the likely mechanisms by which peptide dendrimers act as transdermal permeation enhancers.

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Dendrimers and Hyperbranched Polymers for Drug Delivery

Cited by 17 publications

References 56 publications

PAMAM dendrimer - cell membrane interactions

PAMAM dendrimer - cell membrane interactions

The effect of surface functionality on cellular trafficking of dendrimers

Enhancement in deposition and permeation of 5-fluorouracil through human epidermis assisted by peptide dendrimers

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