Denbinobin suppresses breast cancer metastasis through the inhibition of Src-mediated signaling pathways

Chen, Pei-Hsuan; Peng, Cheng‐Liang; Pai, Hui-Chen; Teng, Che-Ming; Chen, Chien-Chih; Yang, Congrong

doi:10.1016/j.jnutbio.2010.06.004

Cited by 22 publications

(12 citation statements)

References 49 publications

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“…Metastasis is a multi-step process involving detachment of malignant transformed cells from the primary tumor site, attachment to the extracellular matrix (ECM), degradation of the ECM and basement membrane (invasion), and cell migration through the degraded matrix (8). A recent study showed that denbinobin suppresses invasion in mouse breast tumor cells in vitro and metastasis of breast cancer in a mouse metastasis model in vivo (9). Tumor invasion is often associated with the enhanced synthesis and/or activation of matrix-degrading enzymes matrix metalloproteinases (MMPs), among which MMP-2 and MMP-9 are of central importance (10)(11)(12).…”

Section: Introductionmentioning

confidence: 99%

Denbinobin, a phenanthrene from dendrobium nobile, inhibits invasion and induces apoptosis in SNU-484 human gastric cancer cells

Song

Kang²,

Hao³

et al. 2011

Oncol Rep

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Abstract. Dendrobium nobile is widely used as an analgesic, an antipyretic, and a tonic to nourish the stomach in traditional medicine. Mounting evidence suggests an antitumor activity of denbinobin, a major phenanthrene isolated from stems of Dendrobium nobile. The present study aimed to investigate the inhibitory effect of denbinobin on the invasive ability of human cancer cells. The cytotoxicity of denbonobin was examined in several human cancer cell lines including SK-Hep-1 hepatocarcinoma cells, SNU-484 gastric cancer cells, and HeLa cervix cancer cells. Because SNU-484 cells showed the lowest IC 50 value, we examined the effect of denbinobin on the invasive ability of SNU-484 cells. The present study revealed, for the first time, that denbinobin inhibits the invasive phenotype of SNU-484 human gastric cancer cells in a dose-dependent manner. Expressions of matrix metalloproteinase (MMP)-2 and MMP-9 were significantly decreased by denbinobin, suggesting that MMP-2/-9 may be responsible for the antiinvasive activity of denbinobin. We also provide evidence that denbinobin induces apoptosis through down-regulation of Bcl-2 and an up-regulation of Bax. Taken together, this study demonstrates that denbinobin inhibits invasion and induces apoptosis in highly invasive SNU-484 human gastric cancer cells. Given that gastric cancer has been estimated to be one of the most common causes of cancer-related death among Asians and the major cause of death from gastric cancer is the metastatic spread of the disease, our findings may provide useful information regarding the application of denbinobin as a chemopreventive agent that could prevent or alleviate metastatic gastric cancer.

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Section: Introductionmentioning

confidence: 99%

Denbinobin, a phenanthrene from dendrobium nobile, inhibits invasion and induces apoptosis in SNU-484 human gastric cancer cells

Song

Kang²,

Hao³

et al. 2011

Oncol Rep

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“…It is isolated from the stems of Dendrobium moniliforme (Shi-Hu in Chinese medicine). 45 , 46 Denbinobin possesses anti-cancer, anti-inflammatory, 47 anti-angiogenesis, 48 and apoptosis-inducing 49 properties in several types of cancer cells. These effects are particularly relevant to Src kinase, NF-κB, and IGF-1 receptor (IGF-1R) in breast cancer.…”

Section: Denbinobinmentioning

confidence: 99%

“…These effects are particularly relevant to Src kinase, NF-κB, and IGF-1 receptor (IGF-1R) in breast cancer. 45 , 47 …”

Section: Denbinobinmentioning

confidence: 99%

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Natural Products for Chemoprevention of Breast Cancer

Moon

2015

J Cancer Prev

112

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Breast cancer is the primary cause of cancer death in women. Although current therapies have shown some promise against breast cancer, there is still no effective cure for the majority of patients in the advanced stages of breast cancer. Development of effective agents to slow, reduce, or reverse the incidence of breast cancer in high-risk women is necessary. Chemoprevention of breast cancer by natural products is advantageous, as these compounds have few side effects and low toxicity compared to synthetic compounds. In the present review, we summarize natural products which exert chemopreventive activities against breast cancer, such as curcumin, sauchinone, lycopene, denbinobin, genipin, capsaicin, and ursolic acid. This review examines the current knowledge about natural compounds and their mechanisms that underlie breast cancer chemopreventive activity both in vitro and in vivo. The present review may provide information on the use of these compounds for the prevention of breast cancer.

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“…Moreover, its anti-HIV property is also very promising. [36][37][38] In 2014, a research group of the Department of Pharmacognosy, University of Szeged initiated a research program with the aim of investigating the secondary metabolites of Juncaceae species. This program involved the phytochemical and pharmacological investigation of 19 Juncaceae species, and preparative phytochemical work was performed with the most promising species, namely…”

Section: Introductionmentioning

confidence: 99%

Bioactive secondary metabolites from Juncaceae species

Tóth

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Denbinobin suppresses breast cancer metastasis through the inhibition of Src-mediated signaling pathways

Cited by 22 publications

References 49 publications

Denbinobin, a phenanthrene from dendrobium nobile, inhibits invasion and induces apoptosis in SNU-484 human gastric cancer cells

Denbinobin, a phenanthrene from dendrobium nobile, inhibits invasion and induces apoptosis in SNU-484 human gastric cancer cells

Natural Products for Chemoprevention of Breast Cancer

Bioactive secondary metabolites from Juncaceae species

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