Demyelination increases radial diffusivity in corpus callosum of mouse brain

Song, Sheng; Yoshino, Jun; Le, Tai; Lin, Shiow J.; Sun, Shu Wei; Cross, Anne H.; Armstrong, Regina C.

doi:10.1016/j.neuroimage.2005.01.028

Cited by 1,482 publications

(1,416 citation statements)

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“…Third, the underlying biophysical properties derived from the diffusion tensor still need to be elucidated in humans. Although animal model studies have established a link between demyelination and DR (Song et al 2002(Song et al , 2005, this link is Lastly, future studies should explore the contribution of genetic factors, such as the presence of apolipoprotein-E4 allele, as genetics can interact with environmental variables to influence cortical structure (Anttila et al 2004;den Heijer et al 2004;Dufouil et al 2000).…”

Section: Discussionmentioning

confidence: 99%

“…An increased understanding of the neurobiological bases for potential SES-WM integrity relationships can be gained from the joint consideration of FA, radial diffusivity (DR), and axial diffusivity (DA) (Assaf and Pasternak 2008;Burzynska et al 2010;Gold et al 2012). For example, an SES-DR relationship would suggest that SES may help to preserve myelin integrity (Song et al 2002(Song et al , 2005, whereas an SES-DA relationship would suggest a relationship between SES and gross tissue characteristics (Sen and Basser 2005).…”

Section: Introductionmentioning

confidence: 99%

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Socioeconomic status is positively correlated with frontal white matter integrity in aging

Johnson

Kim

Gold

2012

AGE

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Socioeconomic status (SES) is an important reserve variable which has been shown to benefit the aging brain's macrostructure. However, it remains unknown whether SES affects age-related changes in the brain's white matter (WM) microstructure. Here, we used diffusion tensor imaging to explore the relationship between SES and three components of the diffusion tensor [fractional anisotropy (FA), axial diffusivity, and radial diffusivity (DR)]. Participants were 40 (16 male) cognitively normal young adults (mean age=33.3 years, SD=4.27) and 44 (19 male) cognitively normal community dwelling seniors (mean age=66.2 years, SD= 7.5). Age-related FA declines were observed across a large portion of the WM skeleton. However, seniors with high SES showed lower age-related WM integrity declines in three frontal tracts: the right anterior corona radiata and bilateral portions of WM underlying the superior frontal gyri (SFG-WM). Positive SES-FA correlations were primarily driven by negative DR-SES correlations, suggesting that SES may buffer age-related declines in myelin. The functional significance of high SES in these frontal tracts was demonstrated through positive correlations with working memory performance. Possible mechanisms through which SES may attenuate the effects of age on frontal WM integrity are discussed.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Socioeconomic status is positively correlated with frontal white matter integrity in aging

Johnson

Kim

Gold

2012

AGE

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“…These findings may explain why we only observed effects of CST MD, and not of CST FA. Although interpretation of differences in DTI parameters is not straightforward, some studies suggest that λ⊥ may be more sensitive to changes in myelination, extracellular volume fraction, and axonal density (Schwartz et al, 2005;Song et al, 2003Song et al, , 2005, whilst λ || may be more sensitive to differences in axonal diameter (Schwartz et al, 2005). Using a mouse model of retinal ischemia, a DTI and histology study revealed a gradual decrease in relative anisotropy, caused by, at first, decrease in λ || , corresponding with the timing of axonal degeneration, followed by increase in λ⊥, associated with optic nerve demyelination (Song et al, 2003).…”

Section: Discussionmentioning

confidence: 99%

Brain microstructural correlates of visuospatial choice reaction time in children

et al. 2011

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The corticospinal tracts and the basal ganglia continue to develop during childhood and adolescence, and indices of their maturation can be obtained using diffusion-weighted imaging. Here we show that a simple measure of visuomotor function is correlated with diffusion parameters in the corticospinal tracts and neostriatum. In a cohort of 75 typically-developing children aged 7 to 13 years, mean 5-choice reaction times (RTs) were assessed. We hypothesised that children with faster choice RTs would show lower mean diffusivity (MD) in the corticospinal tracts and neostriatum and higher fractional anisotropy (FA) in the corticospinal tracts, after controlling for age, gender, and handedness. Mean MD and/or FA were extracted from the right and left corticospinal tracts, putamen, and caudate nuclei. As predicted, faster 5-choice RTs were associated with lower MD in the corticospinal tracts, putamen, and caudate. MD effects on RT were bilateral in the corticospinal tracts and putamen, whilst right caudate MD was more strongly related to performance than was left caudate MD. Our results suggest a link between motor performance variability in children and diffusivity in the motor system, which may be related to: individual differences in the phase of fibre tract and neostriatal maturation in children of similar age, individual differences in motor experience during childhood (i.e., use-dependent plasticity), and/or more stable individual differences in the architecture of the motor system.

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“…Quantitative maps of the apparent diffusion coefficient, the axial diffusivity and the radial diffusivity were derived using software written in Matlab (MathWorks, Natick, Ma, USA) as described previously (Song et al, 2002(Song et al, , 2005Sun et al, 2003). Regions of interest were placed using ImageJ (Abramoff et al, 2004) on the corpus callosum from the RGB map as described by Lodygensky et al (2010).…”

Section: Post-processingmentioning

confidence: 99%

In vivo assessment of myelination by phase imaging at high magnetic field

et al. 2012

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The present study evaluated the potential of using the phase of T 2 * weighted MR images to characterize myelination during brain development and pathology in rodents at 9.4 T. Phase contrast correlated with myelin content assessed by histology and suggests that most contrast between white and cortical gray matter is modulated by myelin. Ex vivo experiments showed that gray-white matter phase contrast remains unchanged after iron extraction. In dysmyelinated shiverer mice, phase imaging correlated strongly with myelin staining, showing reduced contrast between white and gray matter when compared to healthy controls. We conclude that highresolution phase images, acquired at high field, allow assessment of myelination and dysmyelination.© 2011 Elsevier Inc. All rights reserved. IntroductionThe assessment of myelination in healthy subjects and following injury in humans and in animal models is one of the ways to determine the degree of cerebral integrity or the degree of injury in case of white matter disease like multiple sclerosis. In newborns, myelination of the posterior limb of the internal capsule, when assessed at term equivalent, has been shown to be a very robust predictor of motor impairment (Cowan and de Vries, 2005). A simple technique that would access the degree of myelination of white matter would be very useful in mature animal models of white matter injury such as multiple sclerosis and in immature animal models of white matter injury such as periventricular leukomalacia as well as in human studies. There are various methods available: one approach consists of quantification of myelin bond and free water fractions by a multiexponential analysis of the T 2 decay (Beaulieu et al., 1998;MacKay et al., 1994;Whittall and MacKay, 1989;Lancaster et al., 2003). This is generally performed using a CarrPurcell-Meiboom-Gill (CPMG) or a Turbo Spin-Echo sequences with multiple echo times (Beaulieu et al., 1998). Due to specific absorption rate (SAR) (especially at high fields) and timing constraints, the T 2 decay curve is often not fully sampled for an accurate quantification. Recently, it has been shown that myelin water fraction can also be measured using a multi-exponential analysis of the T 2 * decay in multislice multiple echo gradient echo sequence (Du et al., 2007;Hwang et al., 2010). The resulting myelin water fractions are highly dependent on the constraints introduced on the multi-exponential fitting procedure (Hwang et al., 2010) and suffer from significant inaccuracies in regions close to air-tissue interfaces. An alternative approach of a multicomponent relaxation analysis using multicomponent driven equilibrium single pulse observation of T1 and T2 (mcDESPOT) (Deoni et al., 2008) was applied successfully on infants from 3 to 11 months to quantify myelination (Deoni et al., 2011). Magnetization transfer represents an alternative approach to quantify myelin with new approaches refining its modelization by characterizing individually the relaxation and exchange rates of the free water and macromolec...

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Demyelination increases radial diffusivity in corpus callosum of mouse brain

Cited by 1,482 publications

References 31 publications

Socioeconomic status is positively correlated with frontal white matter integrity in aging

Socioeconomic status is positively correlated with frontal white matter integrity in aging

Brain microstructural correlates of visuospatial choice reaction time in children

In vivo assessment of myelination by phase imaging at high magnetic field

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